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HGF / Hepatocyte Growth Factor

hepatocyte growth factor (hepapoietin A; scatter factor)

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

Gene Name: hepatocyte growth factor (hepapoietin A; scatter factor)
Family/Subfamily: Protease , Serine S1
Synonyms: HGF, DFNB39, Hepatocyte growth factor, Hepatopoeitin-A, Hepapoietin A, Hepatopoietin-A, Scatter factor), SF, F-TCF, HGFB, HPTA, Scatter factor
Target Sequences: X16323 CAA34387.1 P14210

Publications (6)

1
Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-ß in gastric tissue. Ota M, Horiguchi M, Fang V, Shibahara K, Kadota K, Loomis C, Cammer M, Rifkin DB. Cancer research. 2014 74:2642-51. (WB; Human) [Full Text Article] [PubMed:24590056] [PMC:PMC4158836]
2
Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models. Piao Y, Park SY, Henry V, Smith BD, Tiao N, Flynn DL, de Groot JF. Neuro-oncology. 2016 September;18:1230-41. (Human) [Full Text Article] [PubMed:26965451] [PMC:PMC4998992] Related Antibodies: LS-B4657.
3
N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals. Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y Zaytseva, Kathleen L O'Connor, Craig W Vander Kooi, Side Liu, Qing-Bai She. Nature communications. 2019 August;10:3708. [Full Text Article] [PubMed:31420553] [PMC:PMC6697747]
4
Expression of HGF, pMet, and pAkt is related to benefit of radiotherapy after breast-conserving surgery: a long-term follow-up of the SweBCG91-RT randomised trial. Martin Sjöström, Cynthia Veenstra, Erik Holmberg, Per Karlsson, Fredrika Killander, Per Malmström, Emma Niméus, Mårten Fernö, Olle Stål. Molecular oncology. 2020 September; [Full Text Article] [PubMed:32946618] [PMC:PMC7607179] Related Antibodies: LS-B3265.
5
Impaired integrin a5 /ß1 -mediated hepatocyte growth factor release by stellate cells of the aged liver. Friederike Rohn, Claus Kordes, Tobias Buschmann, Doreen Reichert, Marianne Wammers, Gereon Poschmann, Kai Stühler, Amelie S Benk, Fania Geiger, Joachim P Spatz, Dieter Häussinger. Aging cell. 2020 Apr;19:e13131. [Full Text Article] [PubMed:32157808] [PMC:PMC7189994] Related Antibodies: LS-C486534.
6
Expression of hypoxia-inducible factor-1 alpha and hepatocyte growth factor in development of fibrosis in the transplanted kidney. Kellenberger T, Marcussen N, Nyengaard JR, Wogensen L, Jespersen B. Transplant international : official journal of the European Society for Organ Transplantation. Feb;28:180-90. [Full Text Article] [PubMed:25284705] Related Antibodies: LS-B4957.
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Antibodies (154)
Primary (154)
HGF / Hepatocyte Growth Factor (154)
Human (100)
Mouse (48)
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HGF / Hepatocyte Growth Factor Antibody - Anti-HGF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
HGF / Hepatocyte Growth Factor Antibody - Anti-HGF antibody IHC of human brain, cerebellum, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Neuroscience
HGF / Hepatocyte Growth Factor Mouse anti-Human Monoclonal (7-2) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$495
HGF / Hepatocyte Growth Factor Antibody - Anti-HGF antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa216-265) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HGF / Hepatocyte Growth Factor Antibody - Anti-HGF antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa216-265) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
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HGF / Hepatocyte Growth Factor Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA
Unconjugated
100 µl/$375; 200 µl/$473; 400 µl/$648
HGF / Hepatocyte Growth Factor Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-HGF mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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HGF / Hepatocyte Growth Factor Mouse anti-Human Monoclonal (aa200-494) (OTI2F3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
HGF / Hepatocyte Growth Factor Antibody
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HGF / Hepatocyte Growth Factor Mouse anti-Human Monoclonal (A10) Antibody
Human
IP, WB
Unconjugated
100 µg/$500
HGF / Hepatocyte Growth Factor Antibody - Western blot of recombinant HGF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HGF / Hepatocyte Growth Factor Rabbit anti-Mouse Polyclonal (aa482-710) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
HGF / Hepatocyte Growth Factor Antibody - Western blot of recombinant HGF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa32-291) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$281; 200 µl/$311; 500 µl/$411; 1 ml/$461; 2 ml/$562; 5 ml/$962
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$564
HGF / Hepatocyte Growth Factor Antibody - HGF antibody Western blot of ACHN lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa431-480) Antibody
Human
WB
Unconjugated
100 µl/$424
HGF / Hepatocyte Growth Factor Antibody - Western blot analysis of extracts of various cell lines.
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
HGF / Hepatocyte Growth Factor Antibody - 1:100 staining human uterus tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HGF / Hepatocyte Growth Factor Antibody - Immunochemical staining of human HGF in human kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
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HGF / Hepatocyte Growth Factor Rabbit anti-Dog Monoclonal (Preservative Free) (105) Antibody
Dog
ELISA
Unconjugated, Preservative Free
100 µl/$412
HGF / Hepatocyte Growth Factor Antibody - Western blot of recombinant HGF.
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HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa495-728) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$300; 200 µl/$338; 500 µl/$466; 1 ml/$530; 2 ml/$688; 5 ml/$1,149
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HGF / Hepatocyte Growth Factor Rabbit anti-Rat Monoclonal (Preservative Free) (052) Antibody
Rat
ELISA
Unconjugated, Preservative Free
100 µl/$412
HGF / Hepatocyte Growth Factor Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-HGF mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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HGF / Hepatocyte Growth Factor Mouse anti-Human Monoclonal (aa200-494) (OTI3F2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
HGF / Hepatocyte Growth Factor Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
HGF / Hepatocyte Growth Factor Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).