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Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
Gene Name: | excision repair cross-complementing rodent repair deficiency, complementation group 6 |
Synonyms: | ERCC6, ARMD5, Cockayne syndrome B protein, Cockayne syndrome protein CSB, COFS, CSB, Rad26 homolog, ATP-dependent helicase ERCC6, CKN2, COFS1, RAD26, UVSS1 |
Target Sequences: | NM_000124 NP_000115.1 Q03468 |
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