Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ERCC6 / CSB antibody was raised against synthetic peptide SNASPVQVKTAYKCA from an internal region of human CSB / ERCC6 (NP_000115.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Mouse, Rat, Ferret, Bovine, Bat, Elephant, Panda, Rabbit, Pig, Turkey, Chicken, Platypus (100%); Horse, Zebra finch, Lizard (93%); Guinea pig, Pufferfish, Zebrafish, Water flea (87%); Sea squirt, Slime mold (80%).
Human CSB / ERCC6
Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 170kD band observed in nuclear lysates of cell line HeLa (calculated MW of 168kD according to NP_000115.1). Recommended concentration: 0.3-1 ug/ml.
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation.