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TCR Screening ServicesTest your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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CXCR4
chemokine (C-X-C motif) receptor 4
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
| Gene Name: | chemokine (C-X-C motif) receptor 4 |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | CXCR4, CD184, CD184 antigen, Cmkar4, Cxc chemokine receptor 4, CXCR-4, CXC-R4, D2S201E, FB22, Fusin, HM89, LCR1, NPY3R, NPYRL, NPYY3R, Npyy3, HSY3RR, SDF-1 receptor, WHIM, C-x-c chemokine receptor 4, LESTR, Neuropeptide Y receptor Y3, NPYR |
| Target Sequences: | NM_003467 NP_003458.1 P61073 |
Publications (5)
1
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. The Journal of biological chemistry. 2007 282:9547-55.
[PubMed:17289675]
[PMC:PMC2366813]
Related Antibodies: LS-B1986.
2
VEGFR1/ CXCR4 positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1 dependent mechanism. Andrew Wragg, Jason A Mellad, Leilani E Beltran, Mikhail Konoplyannikov, Hong San, Sherry Boozer, Robert J. Deans, Anthony Mathur, Robert J Lederman, Jason C Kovacic, and Manfred Boehm. Journal of molecular medicine (Berlin, Germany). 2008 86:1221-32. (WB, Flo; Mouse, Rat)
[Full Text Article]
[PubMed:18690419]
[PMC:PMC2575081]
3
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E. Blood. 2010 115:5026-36.
[PubMed:20231422]
[PMC:PMC3373152]
Related Antibodies: LS-B1986.
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(149)
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(3)
Neuroscience
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Chicken, Rabbit, Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Human, Monkey, Baboon
Flo, IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$425
Neuroscience
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$425
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR4 Rabbit anti-Human Polyclonal (aa300-349) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$425
CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$425
CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$545
CXCR4 Rabbit anti-Human Polyclonal (aa328-338) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µg/$335
CXCR4 Rat anti-Human Monoclonal (FITC) (A145) Antibody
Human
Flo
FITC Conjugated
50 µg/$355
CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$425
CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$255; 100 µg/$305
CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$755
CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, IP, WB
Unconjugated
0.1 mg/$375
CXCR4 Rat anti-Mouse Monoclonal (PE) (247506) Antibody
Mouse
Flo
PE Conjugated
100 Tests/$620
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR4 Rabbit anti-Human Monoclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$425
CXCR4 Rabbit anti-Human Polyclonal (aa18-33) Antibody
Dog, Sheep, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$590
CXCR4 Rabbit anti-Human Polyclonal Antibody
Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$425
CXCR4 Goat anti-Zebrafish Polyclonal (aa184-193) Antibody
Zebrafish
Peptide-ELISA
Unconjugated
100 µg/$335
CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$335
CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 mg/$425
CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Human, Non-Human Primates
Flo, Func, ICC, IHC-P
Unconjugated
0.1 mg/$255
CXCR4 Goat anti-Human Polyclonal (aa17-42) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
200 µg/$475
CXCR4 Goat anti-Human Polyclonal (aa17-43) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 mg/$425
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