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CXCR4

chemokine (C-X-C motif) receptor 4

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Gene Name: chemokine (C-X-C motif) receptor 4
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR4, CD184, CD184 antigen, Cmkar4, Cxc chemokine receptor 4, CXCR-4, CXC-R4, D2S201E, FB22, Fusin, HM89, LCR1, NPY3R, NPYRL, NPYY3R, Npyy3, HSY3RR, SDF-1 receptor, WHIM, C-x-c chemokine receptor 4, LESTR, Neuropeptide Y receptor Y3, NPYR
Target Sequences: NM_003467 NP_003458.1 P61073

Publications (6)

1
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. The Journal of biological chemistry. 2007 282:9547-55. [PubMed:17289675] [PMC:PMC2366813] Related Antibodies: LS-B1986.
2
VEGFR1/ CXCR4 positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1 dependent mechanism. Andrew Wragg, Jason A Mellad, Leilani E Beltran, Mikhail Konoplyannikov, Hong San, Sherry Boozer, Robert J. Deans, Anthony Mathur, Robert J Lederman, Jason C Kovacic, and Manfred Boehm. Journal of molecular medicine (Berlin, Germany). 2008 86:1221-32. (WB, Flo; Mouse, Rat) [Full Text Article] [PubMed:18690419] [PMC:PMC2575081]
3
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E. Blood. 2010 115:5026-36. [PubMed:20231422] [PMC:PMC3373152] Related Antibodies: LS-B1986.
4
In Vitro Maturation of Cumulus-Oocyte Complexes and In Vitro Sperm Capacitation Significantly Increase the Expression and Enhance the Location of the CXCL12 and CXCR4 Anchoring Attractant Complex in Pigs. Cristina A Martinez, Manuel Alvarez-Rodriguez, Maite Casado-Bedmar, Heriberto Rodriguez-Martinez. Animals: an open access journal from MDPI. 2021 January;11: [Full Text Article] [PubMed:33440865] [PMC:PMC7826865] Related Antibodies: LS-B13299.
5
Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance. Reaux-Le Goazigo A, Rivat C, Kitabgi P, Pohl M, Melik Parsadaniantz S. The European journal of neuroscience. 2012 Sep;36:2619-31. [Full Text Article] [PubMed:22694179] Related Antibodies: LS-A1380.
6
CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2. Ghosh MC, Makena PS, Gorantla V, Sinclair SE, Waters CM. American journal of physiology. Lung cellular and molecular physiology. 2012 May;302:L846-56. [Full Text Article] [PubMed:22345572] [PMC:PMC3362158] Related Antibodies: LS-C250.
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Antibodies (151)
Primary (151)
CXCR4 (151)
Human (137)
Mouse (74)
Rat (52)
African green monkey (1)
Baboon (1)
Bat (15)
Bovine (19)
Cat (1)
Chicken (8)
Chimpanzee (4)
Cynomolgus monkey (1)
Dog (19)
Hamster (22)
Horse (15)
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Non-Human Primates (2)
Pig (17)
Rabbit (20)
Rhesus monkey (1)
Sheep (10)
Sooty Mangabey (1)
Xenopus (5)
Zebrafish (1)
IHC (79)
IHC-Fr (3)
IHC-P (51)
WB (100)
Flo (30)
ELISA (36)
Func (2)
ICC (7)
IF (23)
IP (13)
Peptide-ELISA (3)
rabbit (122)
mouse (15)
goat (10)
rat (4)
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GPCR Database Antibodies (28)
IHCPlus (34)
PathPlus Neuro (2)
IgG (76)
IgG1 (2)
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IgG2a,k (4)
IgG2b (2)
monoclonal mc (20)
polyclonal pc (131)
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AP Conjugated (10)
APC Conjugated (9)
Azide-free (7)
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Unconjugated (75)
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aa50-79 (8)
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270-350 aa, C-terminal (1)
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aa1-359 (1)
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No (147)
Yes (4)
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Chicken, Rabbit, Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) (FITC) Antibody
Chicken, Rabbit, Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P
FITC Conjugated
100 µl/$650
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Human, Baboon, Chimpanzee, African green monkey, Cynomolgus monkey, Rhesus monkey, Sooty Mangabey
Flo, IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$440
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, astrocytes microglia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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CXCR4 Rabbit anti-Human Polyclonal (aa300-349) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$505
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$655
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$555
CXCR4 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$440
CXCR4 Antibody - Western blot of 15 ug of whole cell lysate from HeLa cells with anti-CXCR4 at 1 ug/ml.
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CXCR4 Rabbit anti-Human Polyclonal (aa328-338) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µg/$376
CXCR4 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CXCR4 Rat anti-Human Monoclonal (FITC) (A145) Antibody
Human
Flo
FITC Conjugated
100 µl/$392
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human skin, epidermis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$440
CXCR4 Antibody - Western blot of CXCR4 expression in K562 cells
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CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
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CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$771
CXCR4 Antibody - Immunohistochemistry of CXCR4 in human spleen tissue with CXCR4 antibody at 5 µg/mL.
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CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, IP, WB
Unconjugated
0.1 mg/$420
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CXCR4 Rat anti-Mouse Monoclonal (PE) (247506) Antibody
Mouse
Flo
PE Conjugated
100 Tests/$640
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
Select
CXCR4 Goat anti-Zebrafish Polyclonal (aa184-193) Antibody
Zebrafish
Peptide-ELISA
Unconjugated
100 µg/$374
CXCR4 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CXCR4 Rabbit anti-Human Monoclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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CXCR4 Rabbit anti-Human Polyclonal (aa18-33) Antibody
Dog, Sheep, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$614
CXCR4 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CXCR4 Rabbit anti-Human Polyclonal Antibody
Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CXCR4 Antibody - Immunohistochemistry: CXCR4 Antibody - Figure 1 illustrates immunostaining of CXCR4 in human cervical carcinoma tissue sections.
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CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$376
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CXCR4 Mouse anti-Human Monoclonal Antibody
Human
Flo, IF, IHC
Unconjugated
100 µg/$660
Select
CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 mg/$471
Select
CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Human, Non-Human Primates
Flo, Func, ICC, IHC-P
Unconjugated
0.1 mg/$292
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).