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Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Phone:
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CXCR4

chemokine (C-X-C motif) receptor 4

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Gene Name: chemokine (C-X-C motif) receptor 4
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR4, CD184, CD184 antigen, Cmkar4, Cxc chemokine receptor 4, CXCR-4, CXC-R4, D2S201E, FB22, Fusin, HM89, LCR1, NPY3R, NPYRL, NPYY3R, Npyy3, HSY3RR, SDF-1 receptor, WHIM, C-x-c chemokine receptor 4, LESTR, Neuropeptide Y receptor Y3, NPYR
Target Sequences: NM_003467 NP_003458.1 P61073

Publications (5)

1
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. The Journal of biological chemistry. 2007 282:9547-55. [PubMed:17289675] [PMC:PMC2366813] Related Antibodies: LS-B1986.
2
VEGFR1/ CXCR4 positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1 dependent mechanism. Andrew Wragg, Jason A Mellad, Leilani E Beltran, Mikhail Konoplyannikov, Hong San, Sherry Boozer, Robert J. Deans, Anthony Mathur, Robert J Lederman, Jason C Kovacic, and Manfred Boehm. Journal of molecular medicine (Berlin, Germany). 2008 86:1221-32. (WB, Flo; Mouse, Rat) [Full Text Article] [PubMed:18690419] [PMC:PMC2575081]
3
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E. Blood. 2010 115:5026-36. [PubMed:20231422] [PMC:PMC3373152] Related Antibodies: LS-B1986.
4
Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance. Reaux-Le Goazigo A, Rivat C, Kitabgi P, Pohl M, Melik Parsadaniantz S. The European journal of neuroscience. 2012 Sep;36:2619-31. [Full Text Article] [PubMed:22694179] Related Antibodies: LS-A1380.
5
CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2. Ghosh MC, Makena PS, Gorantla V, Sinclair SE, Waters CM. American journal of physiology. Lung cellular and molecular physiology. 2012 May;302:L846-56. [Full Text Article] [PubMed:22345572] [PMC:PMC3362158] Related Antibodies: LS-C250.
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Antibodies (152)
Primary (152)
CXCR4 (152)
Human (138)
Mouse (75)
Rat (52)
Baboon (1)
Bat (15)
Bovine (19)
Cat (1)
Chicken (8)
Chimpanzee (3)
Dog (19)
Hamster (22)
Horse (15)
Monkey (35)
Non-Human Primates (2)
Pig (17)
Rabbit (20)
Sheep (10)
Xenopus (5)
Zebrafish (1)
IHC (80)
IHC-Fr (3)
IHC-P (52)
WB (101)
Flo (30)
ELISA (37)
Func (2)
ICC (8)
IF (23)
IP (13)
Peptide-ELISA (3)
rabbit (122)
mouse (15)
goat (11)
rat (4)
Product Group
GPCR Database Antibodies (28)
IHCPlus (35)
PathPlus Neuro (2)
IgG (77)
IgG1 (2)
IgG2a (13)
IgG2a,k (2)
IgG2b (2)
monoclonal mc (20)
polyclonal pc (132)
12G5 (5)
247506 (1)
9D9 (1)
A145 (2)
AP Conjugated (10)
APC Conjugated (9)
Azide-free (7)
Biotin Conjugated (13)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (13)
HRP Conjugated (12)
Magnetic beads Conjugated (1)
PE Conjugated (13)
PerCP Conjugated (1)
Sepharose Conjugated (1)
Unconjugated (76)
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aa50-79 (8)
pSer339 (4)
aa14-40 (3)
2nd Extracellular Domain (2)
aa1-14 (2)
aa18-33 (2)
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270-350 aa, C-terminal (1)
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Ser339 (1)
Val340 (1)
aa1-359 (1)
aa17-42 (1)
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aa31-43 (1)
No (149)
Yes (3)
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Chicken, Rabbit, Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Human, Monkey, Baboon
Flo, IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$425
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$425
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, astrocytes microglia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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CXCR4 Rabbit anti-Human Polyclonal (aa300-349) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$425
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$425
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$545
CXCR4 Antibody - Western blot of 15 ug of whole cell lysate from HeLa cells with anti-CXCR4 at 1 ug/ml.
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CXCR4 Rabbit anti-Human Polyclonal (aa328-338) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µg/$335
CXCR4 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CXCR4 Rat anti-Human Monoclonal (FITC) (A145) Antibody
Human
Flo
FITC Conjugated
50 µg/$355
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human skin, epidermis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CXCR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$425
CXCR4 Antibody - Western blot of CXCR4 expression in K562 cells
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CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$255; 100 µg/$305
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CXCR4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$755
CXCR4 Antibody - Immunohistochemistry of CXCR4 in human spleen tissue with CXCR4 antibody at 5 µg/mL.
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CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, IP, WB
Unconjugated
0.1 mg/$375
Select
CXCR4 Rat anti-Mouse Monoclonal (PE) (247506) Antibody
Mouse
Flo
PE Conjugated
100 Tests/$620
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR4 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CXCR4 Rabbit anti-Human Monoclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$425
Select
CXCR4 Rabbit anti-Human Polyclonal (aa18-33) Antibody
Dog, Sheep, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$590
CXCR4 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CXCR4 Rabbit anti-Human Polyclonal Antibody
Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$425
Select
CXCR4 Goat anti-Zebrafish Polyclonal (aa184-193) Antibody
Zebrafish
Peptide-ELISA
Unconjugated
100 µg/$335
CXCR4 Antibody - Immunohistochemistry: CXCR4 Antibody - Figure 1 illustrates immunostaining of CXCR4 in human cervical carcinoma tissue sections.
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CXCR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$335
Select
CXCR4 Goat anti-Mouse Polyclonal (aa14-40) Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 mg/$425
Select
CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Human, Non-Human Primates
Flo, Func, ICC, IHC-P
Unconjugated
0.1 mg/$255
CXCR4 Antibody - IHC of CXCR4 antibody. Formalin-fixed, paraffin-embedded human spleen.
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CXCR4 Goat anti-Human Polyclonal (aa17-42) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
200 µg/$475
CXCR4 Antibody - Immunohistochemistry of paraffin-embeddedi human spleen stained with Goat anti-Human CD184 (N-terminal)
Select
CXCR4 Goat anti-Human Polyclonal (aa17-43) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 mg/$425
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).