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Catalog Number Size Price
LS-A1380-50 50 µg (1 mg/ml) $440 
CXCR4 Antibody - Lung, small cell carcinoma
CXCR4 Antibody - Brain Cerebellum Purkinje Neuron
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CXCR4 Antibody - Lung, small cell carcinoma
CXCR4 Antibody - Brain Cerebellum Purkinje Neuron
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human CXCR4 Antibody (Cytoplasmic Domain, IHC) LS‑A1380

PathPlus™ Polyclonal Rabbit anti‑Human CXCR4 Antibody (Cytoplasmic Domain, IHC) LS‑A1380

Antibody:
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Hamster, Rabbit, Chicken
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$440
LS-A1380-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CXCR4 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Hamster, Rabbit, Chicken
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CXCR4 is a receptor for the C-X-C chemokine CXCL12/SDF-1. It is involved in hematopoiesis and in cardiac ventricular septum formation, and it also plays an essential role in vascularization of the gastrointestinal tract by regulating vascular branching and remodeling processes in endothelial cells. Furthermore, it is involved in cerebellar development, and in the CNS it may function to mediate hippocampal-neuron survival. During embryogenesis and adult life, CXCR4 is important for neuronal guidance and mutations in the gene result in abnormal neuronal distribution. CXCR4 is also a co-receptor (CD4 being the primary receptor) for HIV-1 X4 isolates and a primary receptor for some HIV-2 isolates, and it promotes Env-mediated fusion of the virus. In immunohistochemistry, CXCR4 has membranous positivity in immune cells and the adrenal gland, with some expression in the lung, gastrointestinal tract and other tissues. References: FEBS Letters. 426 (2): 271–8, PMID: 9599023; Journal of Theoretical and Computational Chemistry. 2019. 1 (1): 1–9, DOI: 10.1142/S0219633619500184; Development. 2002. 129 (18): 4249–60, PMID: 12183377.
Target
Human CXCR4
Synonyms
CXCR4 | CD184 | CD184 antigen | Cmkar4 | Cxc chemokine receptor 4 | CXCR-4 | CXC-R4 | D2S201E | FB22 | Fusin | HM89 | LCR1 | NPY3R | NPYRL | NPYY3R | Npyy3 | HSY3RR | SDF-1 receptor | WHIM | C-x-c chemokine receptor 4 | LESTR | Neuropeptide Y receptor Y3 | NPYR
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Hamster, Rabbit, Chicken (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human CXCR4. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Rabbit, Opossum, Turkey, Chicken, Platypus, Lizard (100%).
Epitope
Cytoplasmic Domain
Specificity
Human CXCR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (9 - 14 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CXCR4
P61073 NM_003467 NP_003458.1

Validation

CXCR4 Antibody - Lung, small cell carcinoma
Lung, small cell carcinoma
Lung, small cell carcinoma

CXCR4 Antibody - Brain Cerebellum Purkinje Neuron
Brain Cerebellum Purkinje Neuron
Brain Cerebellum Purkinje Neuron

CXCR4 Antibody - Anti-CXCR4 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR4 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR4 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CXCR4 Antibody - Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CXCR4 Antibody - Anti-CXCR4 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR4 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR4 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ CXCR4 Antibody (Cytoplasmic Domain) for IHC LS-A1380 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance. Reaux-Le Goazigo A, Rivat C, Kitabgi P, Pohl M, Melik Parsadaniantz S. The European journal of neuroscience. 2012 Sep;36:2619-31.

Customer Reviews (0)


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Requested From: United States
Date Requested: 4/13/2021