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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B1986-50 50 µg (0.5 mg/ml) $425 
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
CXCR4 Antibody - Human peripheral blood lymphocytes stained with purified 12G5, followed by biotinylated anti-mouse IgG and Sav-PE
CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
CXCR4 Antibody - Human peripheral blood lymphocytes stained with purified 12G5, followed by biotinylated anti-mouse IgG and Sav-PE
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IHC‑plus™ Monoclonal Mouse anti‑Human CXCR4 Antibody (clone 12G5, IHC, IF) LS‑B1986

IHC‑plus™ Monoclonal Mouse anti‑Human CXCR4 Antibody (clone 12G5, IHC, IF) LS‑B1986

Note: This antibody replaces LS-C41092
Antibody:
CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Application:
IHC, IHC-P, IHC-Fr, IF, Flo
Reactivity:
Human, Baboon, Monkey
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425
LS-B1986-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CXCR4 Mouse anti-Human Monoclonal (12G5) Antibody
Application:
IHC, IHC-P, IHC-Fr, IF, Flo
Reactivity:
Human, Baboon, Monkey
Format:
Unconjugated, Unmodified

Specifications

Description
CXCR4 antibody LS-B1986 is an unconjugated mouse monoclonal antibody to CXCR4 from human. It is reactive with human, baboon and monkey. Validated for Flow, IF and IHC. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
Target
Human CXCR4
Synonyms
CXCR4 | CD184 | CD184 antigen | Cmkar4 | Cxc chemokine receptor 4 | CXCR-4 | CXC-R4 | D2S201E | FB22 | Fusin | HM89 | LCR1 | NPY3R | NPYRL | NPYY3R | Npyy3 | HSY3RR | SDF-1 receptor | WHIM | C-x-c chemokine receptor 4 | LESTR | Neuropeptide Y receptor Y3 | NPYR
Host
Mouse
Reactivity
Human, Baboon, Monkey (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Clone
12G5
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
CP-MAC-infected Sup-T1 cells
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • Immunofluorescence
  • Flow Cytometry
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistochemistry: LS-B1986 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1986 was determined to be 10 ug/ml.
Presentation
Tissue Culture Supernatant, PBS, pH 7.2, 0.09% Sodium Azide
Storage
Store at 4°C. Avoid freezing.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CXCR4
P61073 NM_003467 NP_003458.1

Validation

CXCR4 Antibody - Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

LSBio Ratings

IHC-plus™ CXCR4 Antibody (clone 12G5) for IHC, IF/Immunofluorescence, Flow LS-B1986 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (4)

Publications (2)

Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. The Journal of biological chemistry. 2007 282:9547-55.

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E. Blood. 2010 115:5026-36.

Customer Reviews (0)


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Requested From: United States
Date Requested: 1/24/2021