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BCL2 / Bcl-2

B-cell CLL/lymphoma 2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Gene Name: B-cell CLL/lymphoma 2
Family/Subfamily: Apoptosis
Synonyms: BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50
Target Sequences: NM_000633 NP_000624.2 P10415

Publications (8)

1
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Cancer cell. 2007 12:171-85. (IP) [PubMed:17692808]
2
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. The Journal of biological chemistry. 2012 287:1054-65. [PubMed:22065578] [PMC:PMC3256916] Related Antibodies: LS-C98842.
3
The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Hamed SS, Al-Yhya NA, El-Khadragy MF, Al-Olayan EM, Alajmi RA, Hassan ZK, Hassan SB, Abdel Moneim AE. Frontiers in physiology. 2016 August;7:325. [Full Text Article] [PubMed:27547187] [PMC:PMC4974471]
4
Bmi-1 in gallbladder carcinoma: Clinicopathology and mechanism of regulation of human gallbladder carcinoma proliferation. Jiao K, Jiang W, Zhao C, Su D, Zhang H. Oncology letters. 2019 August;18:1365-1371. [Full Text Article] [PubMed:31423199] [PMC:PMC6607302] Related Antibodies: LS-B6548.
5
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses. Matteo Ugolini, Jenny Gerhard, Sanne Burkert, Kristoffer Jarlov Jensen, Philipp Georg, Friederike Ebner, Sarah M Volkers, Shruthi Thada, Kristina Dietert, Laura Bauer, Alexander Schäfer, Elisa T Helbig, Bastian Opitz, Florian Kurth, Saubashya Sur, Nickel Dittrich, Sumanlatha Gaddam, Melanie L Conrad, Christine S Benn, Ulrike Blohm, Achim D Gruber, Andreas Hutloff, Susanne Hartmann, Mark V Boekschoten, Michael Müller, Gregers Jungersen, Ralf R Schumann, Norbert Suttorp, Leif E Sander. Nature immunology. 2018 April;19:386-396. [Full Text Article] [PubMed:29556002]
6
The Beneficial Effect of Eco-Friendly Green Nanoparticles Using Garcinia mangostana Peel Extract against Pathogenicity of Listeria monocytogenes in Female BALB/c Mice. Afrah F Alkhuriji, Nada A Majrashi, Suliman Alomar, Manal F El-Khadragy, Manal A Awad, Alaa R Khatab, Hany M Yehia. Animals: an open access journal from MDPI. 2020 Mar;10:573. [Full Text Article] [PubMed:32235366] [PMC:PMC7222409]
7
Translational control of Bcl-2 promotes apoptosis of gastric carcinoma cells. Shuangfen Tao, Jianchun Gu, Qing Wang, Leizhen Zheng. BMC cancer. 2021 Jan;21:12. [Full Text Article] [PubMed:33402109] [PMC:PMC7786514]
8
LncRNA H19 aggravates TNF-a-induced inflammatory injury via TAK1 pathway in MH7A cells. Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia. BioFactors (Oxford, England). 2020 September;46:813-820. [Full Text Article] [PubMed:32525617] Related Antibodies: LS-C343557.
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BCL2 / Bcl-2 (320)
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BCL2 / Bcl-2 Antibody - Anti-BCL2 / Bcl-2 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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BCL2 / Bcl-2 Rabbit anti-Human Polyclonal (aa46-95) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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BCL2 / Bcl-2 Rabbit anti-Human Monoclonal (Concentrated) (E17) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$1,169
BCL2 / Bcl-2 Antibody - Formalin-fixed and paraffin-embedded human testis tissue reacted with Bcl-2 BH3 Domain Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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BCL2 / Bcl-2 Rabbit anti-Human Polyclonal (aa75-110) Antibody
Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
BCL2 / Bcl-2 Antibody - Immunohistochemical analysis of BCL2 staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
BCL2 / Bcl-2 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (BL-2) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$380
BCL2 / Bcl-2 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (Magnetic beads) (BL-2) Antibody
Human
IP
Magnetic beads Conjugated
100 µg/$399
BCL2 / Bcl-2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (124) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
50 µg/$460
BCL2 / Bcl-2 Antibody - Bcl-2 antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (Azide-free, BSA-free) (124) Antibody
Dog, Pig, Human, Chimpanzee
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
BCL2 / Bcl-2 Antibody - Formalin-fixed paraffin-embedded section from a secondary follicle of the mouse lymph node stained for Bcl-2 expression using Polyclonal Antibody to Bcl-2 at 1:2000. A, Abundant staining is seen in the mantle zone, and little staining is seen in the germinal center. A1 is a higher magnification of A.
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BCL2 / Bcl-2 Rabbit anti-Mouse Polyclonal (aa67-86) Antibody
Mouse, Rat
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
BCL2 / Bcl-2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
BCL2 / Bcl-2 Mouse anti-Human Recombinant Monoclonal (rBCL2/796) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$525
BCL2 / Bcl-2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
BCL2 / Bcl-2 Mouse anti-Human Recombinant Monoclonal (rBCL2/782) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$525
BCL2 / Bcl-2 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (Bcl-2/100) Antibody
Human
Flo, ICC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
BCL2 / Bcl-2 Antibody - Bcl-2 antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (100/D5) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
BCL2 / Bcl-2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (100/D5) Antibody
Dog, Pig, Human, Chimpanzee
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
50 µg/$460
BCL2 / Bcl-2 Antibody - Immunohistochemistry Dilution at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
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BCL2 / Bcl-2 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$316; 100 µl/$386
BCL2 / Bcl-2 Antibody - BCL2 / Bcl-2 antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BCL2 / Bcl-2 Rabbit anti-Human Polyclonal (aa85-134) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
BCL2 / Bcl-2 Antibody - Western blot analysis of 100 ng Bcl-2 using purified rabbit anti-Bcl-2 primary antibody (1:5,000 µg/ml). The blot was incubated with anti-rabbit HRP-conjugated IgG (1:10,000).
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BCL2 / Bcl-2 Mouse anti-Human Polyclonal (N-term) (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
BCL2 / Bcl-2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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BCL2 / Bcl-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.1 mg/$485
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (Biotin) (1E1-D10-F4) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$343
BCL2 / Bcl-2 Antibody - Anti-BCL2 / Bcl-2 antibody IHC of human colon, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (11C5) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
BCL2 / Bcl-2 Antibody - Bcl-2 antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (8C8) Antibody
Dog, Pig, Human, Monkey, Chimpanzee
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
BCL2 / Bcl-2 Antibody - Immunohistochemistry of paraffin-embedded human lung cancer tissue.
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BCL2 / Bcl-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
BCL2 / Bcl-2 Antibody - Immunohistochemical analysis of BCL2 (pT56) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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BCL2 / Bcl-2 Rabbit anti-Human Polyclonal (pThr56) Antibody
Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$341
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Biotin Conjugated
100 µl/$1,063
BCL2 / Bcl-2 Antibody - Formalin-fixed, paraffin-embedded human non-Hodgkin's lymphoma stained with anti-Bcl-2 antibody (SPM530).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (SPM530) Antibody
Dog, Pig, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).