Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 610/620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

APAF1 / APAF-1

apoptotic peptidase activating factor 1

Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.

Gene Name: apoptotic peptidase activating factor 1
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: APAF1, APAF-1, CED4, KIAA0413
Target Sequences: NM_013229 NP_037361.1 O14727

Publications (1)

1
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. da Silva VK, de Freitas BS, Garcia RCL, Monteiro RT, Hallak JE, Zuardi AW, Crippa JAS, Schröder N. Translational psychiatry. 2018 September;8:176. [Full Text Article] [PubMed:30177808] [PMC:PMC6120904]

☰ Filters
Antibodies (70)
ELISA Kits (23)
Proteins (7)
Cell-Based (1)
Custom (3)
Over-Expression Lysate (3)
Primary (70)
Recombinant (4)
Sandwich (14)
Sandwich CLIA (5)
APAF1 / APAF-1 (100)
Human (69)
Mouse (42)
Rat (25)
C. elegans (5)
Chicken (1)
Dog (1)
Gerbil (2)
Mammal (5)
Monkey (2)
Porcine (1)
Rabbit (1)
IHC (27)
IHC-Fr (1)
IHC-P (15)
WB (61)
Flo (2)
ELISA (18)
ICC (5)
IF (5)
IP (11)
Peptide-ELISA (2)
rabbit (62)
mouse (5)
rat (3)
Product Group
IHCPlus (3)
IgG (32)
IgG1 (2)
IgG1,k (1)
IgG2a,k (3)
IgG2b (2)
monoclonal mc (8)
polyclonal pc (62)
13F11 (1)
18H2 (1)
2E10 (1)
2E12 (1)
2H9A1 (1)
2H9G5 (1)
5C1 (1)
5E11 (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (3)
96-Well Strip Plate (18)
AP Conjugated (2)
APC (2)
APC Conjugated (3)
Biotin Conjugated (5)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (5)
Low Endotoxin (1)
Magnetic beads Conjugated (1)
PE Conjugated (4)
Sepharose Conjugated (1)
Unconjugated (40)
aa31-350 (8)
aa872-1135 (8)
N-Terminus (5)
C-Terminus (2)
aa1-97 (2)
aa12-28 (2)
501-550 aa, Internal (1)
His324 (1)
Internal (1)
Ser320 (1)
aa1-464 (1)
aa1051-1248 (1)
aa289-338 (1)
No (99)
Yes (1)
Adherent Cell Cultures (1)
Cell Lysates (3)
Plasma (9)
Serum (9)
Tissue Homogenates (9)
8His, N-terminus (1)
GST, N-terminus (1)
His (2)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (5)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
APAF1 / APAF-1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
APAF1 / APAF-1 Rat anti-Human Monoclonal (aa1-464) (Low Endotoxin) (2E12) Antibody
Human
ELISA, ICC, IHC, IHC-P, IP, WB
Unconjugated, Low Endotoxin
50 µg/$460
APAF1 / APAF-1 Antibody - Immunohistochemistry of Apaf1 in human heart tissue with Apaf1 antibody at 1 ug/mL.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.1 mg/$460
APAF1 / APAF-1 Antibody - Formalin-fixed, paraffin-embedded sections from a human brain tumor tissue microarray stained for Apaf 1 expression using APAF1 / APAF-1 at 1:2000. A and B. Tissue microarray over view. A1 and B1, higher magnification of cores from A and B, respectively. Differential expression of Apaf 1 is seen between patient samples. Hematoxylin-Eosin counterstain.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
APAF1 / APAF-1 Antibody - Immunohistochemistry of Apaf1 in human skin tissue with Apaf1 antibody at 20 µg/ml.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$460
APAF1 / APAF-1 Antibody - Anti-APAF1 / APAF-1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
250 µl/$485
APAF1 / APAF-1 Antibody - Immunohistochemical analysis of APAF-1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
APAF1 / APAF-1 Antibody - Anti-APAF1 / APAF-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (aa289-338) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
Select
APAF1 / APAF-1 Mouse anti-Human Monoclonal (2H9A1) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µl/$459
APAF1 / APAF-1 Antibody - Staining COLO205 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
APAF1 / APAF-1 Antibody - IHC of APAF-1-ALT (H324) pAb in paraffin-embedded human lung carcinoma tissue.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (His324) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
APAF1 / APAF-1 Antibody - Western blot analysis using anti-Apaf-1 (mouse/rat), MAb (13F11) on purified cells from mouse tissues. The ~130kDa band corresponds to endogenous Apaf-1, which is absent in cells from Apaf-1 KO mice.
Select
APAF1 / APAF-1 Rat anti-Mouse Monoclonal (aa1-97) (13F11) Antibody
Mouse, Rat
ELISA, ICC, IP, WB
Unconjugated
100 µg/$421
APAF1 / APAF-1 Antibody - Western blot analysis using anti-Apaf-1, mAb (18H2) on lysates from mouse cell lines.
Select
APAF1 / APAF-1 Rat anti-Mouse Monoclonal (aa1-97) (18H2) Antibody
Mouse, Human
ELISA, ICC, IP, WB
Unconjugated
100 µg/$421
APAF1 / APAF-1 Antibody - Immunohistochemistry of paraffin-embedded human skin tissue using antibody at 1:100 dilution.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
HEK 293 Cells
8His, N-terminus
52.6 kDa
100 µg/$298
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$856
APAF1 / APAF-1 Antibody - Immunohistochemistry of Apaf-1 antibody
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (501-550 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
APAF1 / APAF-1 Mouse anti-Human Monoclonal (2H9G5) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
APAF1 / APAF-1 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using APAF1 Polyclonal Antibody at dilution of 1:40.
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
APAF1 / APAF-1 Antibody
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Gerbil, Human
IHC, IP, WB
Unconjugated
50 µl/$393
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$603
Select
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
50 µl/$531
Viewing 1-25 of 100 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).