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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
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APAF1 / APAF-1

apoptotic peptidase activating factor 1

Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.

Gene Name: apoptotic peptidase activating factor 1
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: APAF1, APAF-1, CED4, KIAA0413
Target Sequences: NM_013229 NP_037361.1 O14727

Publications (1)

1
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. da Silva VK, de Freitas BS, Garcia RCL, Monteiro RT, Hallak JE, Zuardi AW, Crippa JAS, Schröder N. Translational psychiatry. 2018 September;8:176. [Full Text Article] [PubMed:30177808] [PMC:PMC6120904]

Viewing 1-25 of 80 items
APAF1 / APAF-1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) This image was taken for the unmodified form of this product. Other forms have not been tested.
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Rat Monoclonal [clone 2E12] (IgG2a,k) to Human APAF1 / APAF-1
Human
ELISA, ICC, IHC, IHC-P, IP, WB
Unconjugated, Low Endotoxin
50µg   1mg/ml   $425.00
APAF1 / APAF-1 Antibody - Anti-APAF1 / APAF-1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Rabbit Polyclonal to Human APAF1 / APAF-1
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
250µl   0.2mg/ml   $425.00
APAF1 / APAF-1 Antibody - Anti-APAF1 / APAF-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human APAF1 / APAF-1
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
APAF1 / APAF-1 Antibody - Anti-APAF1 / APAF-1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Rabbit Polyclonal to Human APAF1 / APAF-1
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $515.00
APAF1 / APAF-1 Antibody - Immunohistochemistry of Apaf1 in human heart tissue with Apaf1 antibody at 1 ug/mL.
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Rabbit Polyclonal (IgG) to Human APAF1 / APAF-1
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.1mg   $375.00
APAF1 / APAF-1 Antibody - Formalin-fixed, paraffin-embedded sections from a human brain tumor tissue microarray stained for Apaf 1 expression using APAF1 / APAF-1 at 1:2000. A and B. Tissue microarray over view. A1 and B1, higher magnification of cores from A and B, respectively. Differential expression of Apaf 1 is seen between patient samples. Hematoxylin-Eosin counterstain.
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Rabbit Polyclonal to Human APAF1 / APAF-1
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
APAF1 / APAF-1 Antibody - Immunohistochemistry of Apaf1 in human skin tissue with Apaf1 antibody at 20 µg/ml.
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Rabbit Polyclonal (IgG) to Human APAF1 / APAF-1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1mg   $375.00
APAF1 / APAF-1 Antibody - Immunohistochemical analysis of APAF-1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human APAF1 / APAF-1
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $245.00
APAF1 / APAF-1 Antibody - Staining COLO205 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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Rabbit Polyclonal (IgG) to Human APAF1 / APAF-1
Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
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Rabbit Polyclonal (IgG) to Human APAF1 / APAF-1
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $405.00
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Mouse Monoclonal [clone 2H9A1] (IgG2b) to Human APAF1 / APAF-1
Human
ELISA, Flo, ICC, WB
Unconjugated
100µl   $365.00
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Rat Monoclonal (IgG2a) to Human APAF1 / APAF-1
Human
ELISA, ICC, IHC, IHC-Fr, IP, WB
Unconjugated
100µg   $635.00
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Rat Monoclonal (IgG2a) to Mouse APAF1 / APAF-1
Mouse, Human
ELISA, ICC, IP, WB
Unconjugated
100µg   $650.00
APAF1 / APAF-1 Antibody - IHC of APAF-1-ALT (H324) pAb in paraffin-embedded human lung carcinoma tissue.
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Rabbit Polyclonal to Human APAF1 / APAF-1
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $345.00
APAF1 / APAF-1 Antibody - Western blot analysis using anti-Apaf-1 (mouse/rat), MAb (13F11) on purified cells from mouse tissues. The ~130kDa band corresponds to endogenous Apaf-1, which is absent in cells from Apaf-1 KO mice.
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Rat Monoclonal [clone 13F11] (IgG2a,k) to Mouse APAF1 / APAF-1
Mouse, Rat
ELISA, ICC, IP, WB
Unconjugated
100µg   $375.00
APAF1 / APAF-1 Antibody - Western blot analysis using anti-Apaf-1, mAb (18H2) on lysates from mouse cell lines.
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Rat Monoclonal [clone 18H2] (IgG2a,k) to Mouse APAF1 / APAF-1
Mouse, Human
ELISA, ICC, IP, WB
Unconjugated
100µg   $375.00
APAF1 / APAF-1 Antibody - Immunohistochemistry of paraffin-embedded human skin tissue using antibody at 1:100 dilution.
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Rabbit Polyclonal (IgG) to Human APAF1 / APAF-1
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
APAF1 / APAF-1 Antibody - Immunohistochemistry of Apaf-1 antibody
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Rabbit Polyclonal (IgG) to Human APAF1 / APAF-1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
APAF1 / APAF-1 Antibody - Formalin-fixed, paraffin-embedded tissue section of human pancreatic islets stained for Apaf 1 using APAF1 / APAF-1 Antibody at 1:2000. Hematoxylin-Eosin counterstain.
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Rabbit Polyclonal to Human APAF1 / APAF-1
Human, Monkey
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
APAF1 / APAF-1 Antibody - Formalin-fixed, paraffin-embedded tissue core of human glioma (grade II) stained for Apaf 1 expression using APAF1 / APAF-1 Antibody at 1:2000. A and A1. Low and high magnification, respectively Hematoxylin-Eosin counterstain.
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Rabbit Polyclonal to Human APAF1 / APAF-1
Rabbit, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
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Mouse Monoclonal [clone 2H9G5] (IgG2b) to Human APAF1 / APAF-1
Human
ELISA, Flo, WB
Unconjugated
100µl   $365.00
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Rat Monoclonal (IgG2a) to Mouse APAF1 / APAF-1
Mouse, Rat
ICC, IP, WB
Unconjugated
100µg   $680.00
APAF1 / APAF-1 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using APAF1 Polyclonal Antibody at dilution of 1:40.
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Rabbit Polyclonal (IgG) to Human APAF1 / APAF-1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.7mg/ml   $205.00; 60µl   0.7mg/ml   $235.00; 120µl   0.7mg/ml   $295.00; 200µl   0.7mg/ml   $395.00
APAF1 / APAF-1 Antibody
Select
Rabbit Polyclonal to Human APAF1 / APAF-1
Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $265.00
Select
Rabbit Polyclonal to Human APAF1 / APAF-1
Human
IHC, IP, WB
Unconjugated
50µl   $325.00

Viewing 1-25 of 80 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).