Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Catalog Number Size Price
LS-B13920-50 50 µl (0.5 mg/ml) $460 
ADAM10 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ADAM10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ADAM10 Antibody - Western Blot; Sample: Human Placenta Tissue.
ADAM10 Antibody - Western Blot; Sample: Recombinant ADAM10, Human.
ADAM10 Antibody - Western blot of recombinant ADAM10.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ADAM10 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ADAM10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
ADAM10 Antibody - Western Blot; Sample: Human Placenta Tissue.
ADAM10 Antibody - Western Blot; Sample: Recombinant ADAM10, Human.
ADAM10 Antibody - Western blot of recombinant ADAM10.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
1 of 5
2 of 5
3 of 5
4 of 5
5 of 5

PathPlus™ Polyclonal Rabbit anti‑Human ADAM10 Antibody (aa420‑641, IHC, WB) LS‑B13920

PathPlus™ Polyclonal Rabbit anti‑Human ADAM10 Antibody (aa420‑641, IHC, WB) LS‑B13920

Note: This antibody replaces LS-C292558
Antibody:
ADAM10 Rabbit anti-Human Polyclonal (aa420-641) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-B13920-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
ADAM10 Rabbit anti-Human Polyclonal (aa420-641) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
ADAM10 (A disintegrin and metalloproteinase domain-containing protein 10, CD156c) is a cell surface protein that is responsible for the proteolytic release of other cell-surface proteins on endothelial cells, including soluble JAM3, heparin-binding epidermal growth-like factor, TNF-alpha, E-cadherin and ephrin-A2. It is further responsible for the constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) and contributes to the normal cleavage of the cellular prion protein. It also has vesicle-based protease activity. ADAM10 also regulates the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Increased expression of this protein in hippocampal neuronal synapses is found in the brains of Alzheimer’s disease patients. In breast cancer, inhibitors that target ADAM10 used in conjunction with Herceptin may be an effective therapy for some HER2-upregulated patients. In immunohistochemistry, ADAM10 has membranous and cytoplasmic staining in a variety of tissues including the brain, thyroid, gastrointestinal tract, liver, kidney, reproductive tissues, skin and immune tissues. References: Cold Spring Harbor Perspectives in Medicine. 2 (5): a006270, PMID: 22553493; Cancer Biology & Therapy. 5 (6): 657–64, PMID: 16627989; PLoS One. 2016 May 25;11(5):e0156184, PMID: 27224017;
Target
Human ADAM10
Synonyms
ADAM10 | AD10 | ADAM 10 | Kuzbanian | HsT18717 | CD156c | CD156c antigen | CDw156 | Kuz | Kuzbanian protein homolog | MADM
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Modifications
Unmodified
Immunogen
Recombinant ADAM10 (Arg420-Val641) expressed in E. coli.
Epitope
aa420-641
Specificity
The antibody is a rabbit polyclonal antibody raised against ADAM10. It has been selected for its ability to recognize ADAM10 in immunohistochemical staining and western blotting.
Applications
  • IHC
  • IHC - Paraffin (15 µg/ml)
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
ELISA 0.05-2ug/ml; ICC 5-20ug/ml; IHCP 15 ug/ml; WB 1-5ug/ml;
Presentation
PBS, pH 7.4, 0.02% Sodium Azide, 50% Glycerol
Storage
Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ADAM10
O14672 NM_001110 NP_001101.1

Validation

ADAM10 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.

ADAM10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.

LSBio Ratings

PathPlus™ ADAM10 Antibody (aa420-641) for IHC, WB/Western LS-B13920 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 5/25/2022