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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
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866-819-4732 (Toll Free North America
206-374-1102 (International)
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PathPlusTM ADAM10 Antibodies
ADAM10 (A disintegrin and metalloproteinase domain-containing protein 10, CD156c) is a cell surface protein that is responsible for the proteolytic release of other cell-surface proteins on endothelial cells, including soluble JAM3, heparin-binding epidermal growth-like factor, TNF-alpha, E-cadherin and ephrin-A2. It is further responsible for the constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) and contributes to the normal cleavage of the cellular prion protein. It also has vesicle-based protease activity. ADAM10 also regulates the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Increased expression of this protein in hippocampal neuronal synapses is found in the brains of Alzheimer’s disease patients. In breast cancer, inhibitors that target ADAM10 used in conjunction with Herceptin may be an effective therapy for some HER2-upregulated patients. In immunohistochemistry, ADAM10 has membranous and cytoplasmic staining in a variety of tissues including the brain, thyroid, gastrointestinal tract, liver, kidney, reproductive tissues, skin and immune tissues. References: Cold Spring Harbor Perspectives in Medicine. 2 (5): a006270, PMID: 22553493; Cancer Biology & Therapy. 5 (6): 657–64, PMID: 16627989; PLoS One. 2016 May 25;11(5):e0156184, PMID: 27224017;

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ADAM10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
Rabbit Polyclonal to Human ADAM10
Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $425.00

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