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ADAM10

ADAM metallopeptidase domain 10

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Gene Name: ADAM metallopeptidase domain 10
Family/Subfamily: Protease , Metallopeptidase M12B
Synonyms: ADAM10, AD10, ADAM 10, Kuzbanian, HsT18717, CD156c, CD156c antigen, CDw156, Kuz, Kuzbanian protein homolog, MADM
Target Sequences: NM_001110 NP_001101.1 O14672

Publications (2)

1
High percentage of ADAM-10 positive melanoma cells correlates with paucity of tumor-infiltrating lymphocytes but does not predict prognosis in cutaneous melanoma patients. Donizy P, Zietek M, Leskiewicz M, Halon A, Matkowski R. Analytical cellular pathology (Amsterdam). 2015 2015: (WB; Human) [Full Text Article] [PubMed:26266086] [PMC:PMC4525148]
2
Peripheral Amyloid Precursor Protein Derivative Expression in Fragile X Syndrome. McLane RD, Schmitt LM, Pedapati EV, Shaffer RC, Dominick KC, Horn PS, Gross C, Erickson CA. Frontiers in integrative neuroscience. 2019 September;13: [Full Text Article] [PubMed:31551722] [PMC:PMC6733993]

☰ Filters
Antibodies (57)
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ADAM10 Antibody - Western blot analysis of extracts of various cell lines, using ADAM10 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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ADAM10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
ADAM10 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$752
ADAM10 ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
ADAM10 Antibody - Immunocytochemical staining of K562 cells using ADAM10 antibody at 2 µg/ml.
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ADAM10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1 mg/$420
ADAM10 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$772
ADAM10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ADAM10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC-P, WB
Unconjugated
50 µl/$460
ADAM10 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$809
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ADAM10 Goat anti-Human Polyclonal (aa214-672) Antibody
Human
ELISA, IHC, WB
Unconjugated
1 mg/$840
ADAM10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
ADAM10 Rabbit anti-Human Polyclonal (aa420-641) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ADAM10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
ADAM10 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using ADAM10 Polyclonal Antibody at dilution of 1:30.
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ADAM10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$242; 60 µl/$284; 120 µl/$343; 200 µl/$451
ADAM10 Antibody - Western blot of ADAM10 antibody
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ADAM10 Rabbit anti-Human Polyclonal (170-250 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
ADAM10 Antibody - Western blot - Anti-ADAM10 Picoband antibody
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ADAM10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$421
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ADAM10 Mouse anti-Human Monoclonal (CF) Antibody
Human
Flo
CF Conjugated
100 Tests/$610
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ADAM10 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$725
ADAM10 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at dilution of 1:100.
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ADAM10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$284; 100 µg/$348
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ADAM10 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
50 µg/$284; 100 µg/$348
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ADAM10 Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Bovine, Human
IF, IHC, WB
HRP Conjugated
100 µl/$859
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ADAM10 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Bovine, Human
IF, IHC, WB
Biotin Conjugated
100 µl/$859
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ADAM10 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Bovine, Human
IF, IHC, WB
FITC Conjugated
100 µl/$859
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ADAM10 Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Bovine, Human
IF, IHC, WB
APC Conjugated
100 µl/$859
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ADAM10 Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Bovine, Human
IF, IHC, WB
PE Conjugated
100 µl/$859
ADAM10 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded Human Lymph, antibody was diluted at 1:100.
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ADAM10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
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ADAM10 Rabbit-New Zealand White anti-Human Polyclonal (aa390-440) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$369
ADAM10 Antibody
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ADAM10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$317
Viewing 1-25 of 83 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).