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Catalog Number Size Price
LS-A2583-50 50 µg (1 mg/ml) $425 
F2R / Thrombin Receptor / PAR1 Antibody - Colon, Carcinoma
F2R / Thrombin Receptor / PAR1 Antibody - Lung, Non Small-Cell Carcinoma
F2R / Thrombin Receptor / PAR1 Antibody - Anti-F2R / Thrombin Receptor / PAR1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2R / Thrombin Receptor / PAR1 Antibody - Anti-Thrombin Receptor antibody IHC of human bone marrow, megakaryocyte. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2R / Thrombin Receptor / PAR1 Antibody - Colon, Carcinoma
F2R / Thrombin Receptor / PAR1 Antibody - Lung, Non Small-Cell Carcinoma
F2R / Thrombin Receptor / PAR1 Antibody - Anti-F2R / Thrombin Receptor / PAR1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2R / Thrombin Receptor / PAR1 Antibody - Anti-Thrombin Receptor antibody IHC of human bone marrow, megakaryocyte. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal F2R / Thrombin Receptor / PAR1 Antibody (N‑Terminus, IHC) LS‑A2583

PathPlus™ Polyclonal F2R / Thrombin Receptor / PAR1 Antibody (N‑Terminus, IHC) LS‑A2583

Antibody:
Rabbit Polyclonal to Human F2R / Thrombin Receptor / PAR1
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A2583-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human F2R / Thrombin Receptor / PAR1
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
F2R (Coagulation factor II thrombin receptor) is a Proteinase-Activated Receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. Thrombin induces RANTES expression via a PAR-1 mediated pathway and influences inflammatory cell migration to the synovium in patients with rheumatoid arthritis. It is important for vascular development, and functions as a negative regulator of hematopoietic differentiation of stem cells during embryogenesis and development. In immunohistochemistry, it has membranous positivity at variable levels in a wide range of tissues and is present in blood vessels. References: Ann Rheum Dis. 2002 Sep;61(9):834-7, PMID: 12176812; Developmental Cell. 2012. 22(5), 15 May 2012:1092-1100;
Target
Human F2R / Thrombin Receptor / PAR1
Synonyms
F2R | CF2R | Coagulation factor II receptor | PAR1 | PAR-1 | Thrombin receptor | TR | HTR | Protease-activated receptor 1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (11 - 17 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 18 amino acid peptide from N-Terminus extracellular domain of human Thrombin Receptor. Percent identity with other species by BLAST analysis: Human (100%); Baboon, Monkey (94%); Gorilla, Gibbon (89%); Marmoset (83%).
Blocking Peptide
LS-E28576 - Liquid - 50 µg 1 mg/ml - $145.00
Immunizing peptide used to generate LS-A2583. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human Thrombin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About F2R / Thrombin Receptor / PAR1
P25116 NM_001992 NP_001983.2

Validation

F2R / Thrombin Receptor / PAR1 Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

F2R / Thrombin Receptor / PAR1 Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

F2R / Thrombin Receptor / PAR1 Antibody - Anti-F2R / Thrombin Receptor / PAR1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2R / Thrombin Receptor / PAR1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2R / Thrombin Receptor / PAR1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

F2R / Thrombin Receptor / PAR1 Antibody - Anti-Thrombin Receptor antibody IHC of human bone marrow, megakaryocyte. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Thrombin Receptor antibody IHC of human bone marrow, megakaryocyte. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Thrombin Receptor antibody IHC of human bone marrow, megakaryocyte. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ F2R / Thrombin Receptor / PAR1 Antibody (N-Terminus) for IHC LS-A2583 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 4/6/2020