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XPO1 / CRM1 Antibody (Biotin) LS‑C500043

Antibody

XPO1 / CRM1 Antibody (Biotin) LS‑C500043

Antibody:
Rabbit Polyclonal to Human XPO1 / CRM1
Application:
ELISA
Reactivity:
Human
Format:
Biotin, Unmodified
Other formats:
Price
Catalog Number
$285 
LS-C500043-50
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human XPO1 / CRM1
Application:
ELISA
Reactivity:
Human
Format:
Biotin, Unmodified
Other formats:

Specifications

Description
CRM1 antibody LS-C500043 is a biotin-conjugated rabbit polyclonal antibody to human CRM1 (XPO1). Validated for ELISA.
Target
Human XPO1 / CRM1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Biotin. Also available Unconjugated or conjugated with FITC, HRP.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • ELISA
  • (applications tested for the base form of this product only)
Immunogen
XPO1 / CRM1 antibody was raised against recombinant Human Exportin-1 protein (625-845AA)
Specificity
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About XPO1 / CRM1
O14980 NM_003400 NP_003391.1

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Requested From: United States
Date Requested: 7/22/2019
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