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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-C500034-50 50 µg $285 
LS-C500034-100 100 µg $385 
XPO1 / CRM1 Antibody - Immunohistochemistry of paraffin-embedded human pancreatic tissue using XPO1 Antibody at dilution of 1:100
XPO1 / CRM1 Antibody - Immunohistochemistry of paraffin-embedded human testis tissue using XPO1 Antibody at dilution of 1:100
XPO1 / CRM1 Antibody - Immunofluorescent analysis of Hela cells using XPO1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
XPO1 / CRM1 Antibody - Positive WB detected in:K562 whole cell lysate,NIH/3T3 whole cell lysate;All lanes:XPO1 antibody at 3?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 124 KDa;Observed band size: 124 KDa;
XPO1 / CRM1 Antibody - Immunohistochemistry of paraffin-embedded human pancreatic tissue using XPO1 Antibody at dilution of 1:100
XPO1 / CRM1 Antibody - Immunohistochemistry of paraffin-embedded human testis tissue using XPO1 Antibody at dilution of 1:100
XPO1 / CRM1 Antibody - Immunofluorescent analysis of Hela cells using XPO1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
XPO1 / CRM1 Antibody - Positive WB detected in:K562 whole cell lysate,NIH/3T3 whole cell lysate;All lanes:XPO1 antibody at 3?g/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 124 KDa;Observed band size: 124 KDa;
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Polyclonal XPO1 / CRM1 Antibody (IHC, IF, WB) LS‑C500034

Polyclonal XPO1 / CRM1 Antibody (IHC, IF, WB) LS‑C500034

Antibody:
Rabbit Polyclonal to Human XPO1 / CRM1
Application:
IHC, IF, WB, ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$285 
LS-C500034-50
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human XPO1 / CRM1
Application:
IHC, IF, WB, ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CRM1 antibody LS-C500034 is an unconjugated rabbit polyclonal antibody to CRM1 (XPO1 ) from human and mouse. Validated for ELISA, IF, IHC and WB.
Target
Human XPO1 / CRM1
Synonyms
XPO1 | CRM1, yeast, homolog | Exp1 | Exportin-1 | CRM1
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with FITC, HRP, Biotin.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • Immunofluorescence
  • Western blot
  • ELISA
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Recombinant Human Exportin-1 protein (625-845AA)
Specificity
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About XPO1 / CRM1
O14980 NM_003400 NP_003391.1

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Requested From: United States
Date Requested: 2/17/2020