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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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XPO1 / CRM1

exportin 1 (CRM1 homolog, yeast)

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Gene Name: exportin 1 (CRM1 homolog, yeast)
Synonyms: XPO1, CRM1, yeast, homolog, Exp1, Exportin-1, CRM1
Target Sequences: NM_003400 NP_003391.1 O14980

Filtered by: None
Target
XPO1 / CRM1 (38)
Reactivity
Human (38)
Mouse (19)
Rat (13)
Bat (5)
Bovine (10)
Chicken (5)
Chimpanzee (3)
Dog (9)
Gibbon (6)
Horse (9)
Monkey (9)
Pig (12)
Rabbit (8)
Xenopus (5)
Zebrafish (4)
Application
IHC (9)
IHC-Fr (1)
IHC-P (7)
WB (31)
Flo (4)
ELISA (8)
ICC (2)
IF (1)
IP (5)
Host
rabbit (35)
mouse (3)
Isotype
IgG (20)
IgG2b (3)
Clonality
monoclonal mc (3)
polyclonal pc (35)
Format
APC (1)
APC Conjugated (1)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (1)
DY550 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (20)
Epitope
aa917-1071 (8)
C-Terminus (4)
aa809-858 (4)
aa1025-C-term (2)
Acetyl-Lys568 (1)
Internal (1)
aa375-425 (1)
aa390-408 (1)
aa817-846 (1)
Publications
No (38)
Showing 1-25 of 38 results

XPO1 / CRM1 Antibody (aa390-408) IHC-plus™ LS-B1776
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Xenopus, Chicken, Bovine, Bat, Dog, Horse, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

XPO1 / CRM1 Antibody LS-C756643
Mouse Monoclonal (IgG2b) to Human XPO1 / CRM1
Human
Flo ICC IHC-Fr IHC-P WB
Unconjugated
100µg  $355.00
IHC analysis of CRM1 using anti-CRM1 antibody. CRM1 was detected in paraffin-embedded section of human lung cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml mouse anti-CRM1 Antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
IHC analysis of CRM1 using anti-CRM1 antibody. CRM1 was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml mouse anti-CRM1 Antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.

XPO1 / CRM1 Antibody (aa1025-C-term) IHC-plus™ LS-B11039
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
IHC IHC-P
Unconjugated
50µl  $425.00
Anti-XPO1 / CRM1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

XPO1 / CRM1 Antibody (aa1025-C-term) IHC-plus™ LS-B11299
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
IHC IHC-P IP WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-XPO1 / CRM1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Detection of Human and Mouse CRM1 by Western Blot. Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, Jurkat, and mouse TCMK-1 cells. Antibodies: Affinity purified rabbit anti-CRM1 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

XPO1 / CRM1 Antibody LS-C500034
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
ELISA IF IHC WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human testis tissue using XPO1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using XPO1 Antibody at dilution of 1:100

XPO1 / CRM1 Antibody (HRP) LS-C500037
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

XPO1 / CRM1 Antibody (Biotin) LS-C500043
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

XPO1 / CRM1 Antibody (FITC) LS-C500033
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
ELISA
FITC Conjugated
50µg  $285.00; 100µg  $385.00

XPO1 / CRM1 Antibody (aa809-858) LS-C80338
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $385.00
Fetal heart cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 6%-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

XPO1 / CRM1 Antibody (aa817-846) LS-C98422
Rabbit Polyclonal to Human XPO1 / CRM1
Mouse, Human
Flo IHC IHC-P WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human brain tissue reacted with XPO1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of XPO1 antibody in mouse bladder tissue lysates (35 ug/lane). XPO1 (arrow) was detected using the purified antibody.

XPO1 / CRM1 Antibody LS-C664800
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
ELISA IHC IP WB
Unconjugated
100µg  $335.00

XPO1 / CRM1 Antibody LS-C661891
Rabbit Polyclonal to Human XPO1 / CRM1
Human
IHC IHC-P WB
Unconjugated
100µg  $355.00
CRM1 was detected in paraffin-embedded sections of mouse intestine tissues using rabbit anti- CRM1 Antigen Affinity purified polyclonal antibody
CRM1 was detected in paraffin-embedded sections of rat testis tissues using rabbit anti- CRM1 Antigen Affinity purified polyclonal antibody

XPO1 / CRM1 Antibody LS-C404676
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 60µl 0.5mg/ml  $235.00; 120µl 0.5mg/ml  $295.00; 200µl 0.5mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human thyroid cancer using XPO1 Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of paraffin-embedded Human liver cancer using XPO1 Polyclonal Antibody at dilution of 1:25.

XPO1 / CRM1 Antibody LS-C490672
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µg  $435.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

XPO1 / CRM1 Antibody (aa917-1071) LS-C372920
Rabbit Polyclonal to Human XPO1 / CRM1
Pig, Human
ICC IP WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00
Western blot of XPO1 / CRM1 antibody.
Western Blot; Sample: Lane1: Human Hela Cells; Lane2: Human K562 Cells; Lane3: Human Lung Tissue; Lane4: Porcine Intestine Tissue.

XPO1 / CRM1 Antibody LS-C763806
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Rat, Human
ELISA WB
Unconjugated
20µl 1mg/ml  $195.00; 60µl 1mg/ml  $235.00; 120µl 1mg/ml  $285.00; 200µl 1mg/ml  $375.00

XPO1 / CRM1 Antibody (Internal) LS-C387607
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Rat, Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Acetyl-CRM1 (K568) antibody
Western blot of Acetyl-CRM1 (K568) antibody

XPO1 / CRM1 Antibody LS-C355512
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Bovine, Human
IP WB
Unconjugated
100µg  $445.00
WB using Exportin 1 / CRM1 Antibody
WB using Exportin 1 / CRM1 Antibody

XPO1 / CRM1 Antibody (DY550) LS-C756646
Mouse Monoclonal (IgG2b) to Human XPO1 / CRM1
Human
Flo
DY550 Conjugated
100µg  $365.00

XPO1 / CRM1 Antibody (DY488) LS-C756644
Mouse Monoclonal (IgG2b) to Human XPO1 / CRM1
Human
Flo
DY488 Conjugated
100µg  $365.00
Flow Cytometry analysis of K562 cells using anti-Human CRM1 antibody. Overlay histogram showing K562 cells stained with anti-Human CRM1 antibody (Blue line). The cells were blocked with 10% normal goat serum. And then incubated with mouse anti-Human CRM1 Antibody (1µg/10E6 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-mouse IgG (5-10µg/10E6 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was mouse IgG (1µg/10E6 cells) used under the same conditions. Unlabelled sample (Red line) was also used as a control.

XPO1 / CRM1 Antibody LS-C771864
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $285.00; 200µl 1mg/ml  $375.00

XPO1 / CRM1 Antibody (C-Terminus) LS-C110522
Rabbit Polyclonal to Human XPO1 / CRM1
Zebrafish, Horse, Rat, Rabbit, Mouse, Dog, Bovine, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
XPO1 / CRM1 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

XPO1 / CRM1 Antibody (Acetyl-Lys568) LS-C413271
Rabbit Polyclonal to Human XPO1 / CRM1
Mouse, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $295.00
Western blot analysis of XPO1 (AcK568) expression in HepG2 UV-treated (A); mouse brain (B) whole cell lysates.

XPO1 / CRM1 Antibody LS-C330908
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of HeLa cells.
Western blot analysis of extracts of various cell lines, using XPO1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 1s.

XPO1 / CRM1 Antibody (aa375-425) LS-C287376
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
IP
Unconjugated
100µl 1mg/ml  $395.00
Showing 1-25 of 38 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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