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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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XPO1 / CRM1

exportin 1 (CRM1 homolog, yeast)

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Gene Name: exportin 1 (CRM1 homolog, yeast)
Synonyms: XPO1, CRM1, yeast, homolog, Exp1, Exportin-1, CRM1
Target Sequences: NM_003400 NP_003391.1 O14980

Viewing 1-25 of 38 items
XPO1 / CRM1 Antibody - Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Xenopus, Chicken, Bovine, Bat, Dog, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
XPO1 / CRM1 Antibody - Anti-XPO1 / CRM1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
IHC, IHC-P
Unconjugated
50µl   $425.00
XPO1 / CRM1 Antibody - Anti-XPO1 / CRM1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50µl   1mg/ml   $425.00
XPO1 / CRM1 Antibody - IHC analysis of CRM1 using anti-CRM1 antibody. CRM1 was detected in paraffin-embedded section of human lung cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml mouse anti-CRM1 Antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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Mouse Monoclonal (IgG2b) to Human XPO1 / CRM1
Human
Flo, ICC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $355.00
XPO1 / CRM1 Antibody - Immunohistochemistry of paraffin-embedded human testis tissue using XPO1 Antibody at dilution of 1:100
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Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
ELISA
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
ELISA
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
ELISA
FITC Conjugated
50µg   $285.00; 100µg   $385.00
XPO1 / CRM1 Antibody - Fetal heart cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 6%-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $385.00
XPO1 / CRM1 Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with XPO1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human XPO1 / CRM1
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $335.00
XPO1 / CRM1 Antibody - CRM1 was detected in paraffin-embedded sections of mouse intestine tissues using rabbit anti- CRM1 Antigen Affinity purified polyclonal antibody
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Rabbit Polyclonal to Human XPO1 / CRM1
Human
IHC, IHC-P, WB
Unconjugated
100µg   $355.00
XPO1 / CRM1 Antibody
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µg   $435.00
XPO1 / CRM1 Antibody - Western blot of XPO1 / CRM1 antibody.
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Rabbit Polyclonal to Human XPO1 / CRM1
Pig, Human
ICC, IP, WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $530.00
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Rat, Human
ELISA, WB
Unconjugated
20µl   1mg/ml   $205.00; 60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
XPO1 / CRM1 Antibody - Western blot of Acetyl-CRM1 (K568) antibody
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Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
XPO1 / CRM1 Antibody - WB using Exportin 1 / CRM1 Antibody
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Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Bovine, Human
IP, WB
Unconjugated
100µg   $445.00
Select
Mouse Monoclonal (IgG2b) to Human XPO1 / CRM1
Human
Flo
DY550 Conjugated
100µg   $365.00
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
XPO1 / CRM1 Antibody - Flow Cytometry analysis of K562 cells using anti-Human CRM1 antibody. Overlay histogram showing K562 cells stained with anti-Human CRM1 antibody (Blue line). The cells were blocked with 10% normal goat serum. And then incubated with mouse anti-Human CRM1 Antibody (1µg/10E6 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-mouse IgG (5-10µg/10E6 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was mouse IgG (1µg/10E6 cells) used under the same conditions. Unlabelled sample (Red line) was also used as a control.
Select
Mouse Monoclonal (IgG2b) to Human XPO1 / CRM1
Human
Flo
DY488 Conjugated
100µg   $365.00
XPO1 / CRM1 Antibody - Western blot analysis of XPO1 (AcK568) expression in HepG2 UV-treated (A); mouse brain (B) whole cell lysates.
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Rabbit Polyclonal to Human XPO1 / CRM1
Mouse, Rat, Human
WB
Unconjugated
100µl   1mg/ml   $295.00
XPO1 / CRM1 Antibody - XPO1 / CRM1 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human XPO1 / CRM1
Zebrafish, Horse, Rat, Rabbit, Mouse, Dog, Bovine, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
XPO1 / CRM1 Antibody - Western blot analysis of extracts of HeLa cells.
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Mouse, Human
WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human XPO1 / CRM1
Human
IP
Unconjugated
100µl   1mg/ml   $395.00

Viewing 1-25 of 38 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).