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Catalog Number Size Price
LS-C11553-0.1 0.1 mg (1 mg/ml) $368 
Antibody

Monoclonal Mouse anti‑Human TP53 / p53 Antibody (clone DO‑1, aa20‑25, IHC, WB) LS‑C11553

Monoclonal Mouse anti‑Human TP53 / p53 Antibody (clone DO‑1, aa20‑25, IHC, WB) LS‑C11553

Note: This antibody replaces LS-C43831
Antibody:
TP53 / p53 Mouse anti-Human Monoclonal (aa20-25) (DO-1) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB, IP, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$368
LS-C11553-0.1
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
TP53 / p53 Mouse anti-Human Monoclonal (aa20-25) (DO-1) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB, IP, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
P53 antibody LS-C11553 is an unconjugated mouse monoclonal antibody to human p53 (TP53) (aa20-25). Validated for ELISA, IHC, IP and WB. Cited in 1 publication.
Target
Human TP53 / p53
Synonyms
TP53 | BCC7 | Cellular tumor antigen p53 | p53 | TRP53 | p53 tumor suppressor | Phosphoprotein p53 | Antigen NY-CO-13 | Tumor protein p53 | Tumor suppressor p53 | LFS1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Non-Reactivity
Mouse, Rat
Clonality
IgG2a Monoclonal
Clone
DO-1
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant human p53 (AA 20-25)
Epitope
aa20-25
Specificity
Recognizes the human p53 tumor suppressor protein, also known as cellular tumor antigen p53 or NY-CO-13. Clone DO-1 binds to both wild type and mutant forms of the p53 protein found in various malignancies. p53 is important in multicellular organisms, where it regulates cell cycle progression to allow DNA repair or apoptosis in the case of irreparably damaged cells and thus functions as a tumor suppressor that is involved in preventing cancer. Mutations in the p53 gene are found in about half the cases of human cancerrecognizes an epitope at the N-terminal end of p53 between amino acids 20-25, common to isoforms 1-3 of p53.
Applications
  • IHC
  • IHC - Paraffin (1:25)
  • IHC - Frozen
  • Western blot (1:1000)
  • Immunoprecipitation
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. We recommend the use of 0.01 M citrate buffer for this purpose.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About TP53 / p53
P04637 NM_000546 NP_000537.3

LSBio Ratings

TP53 / p53 Antibody (aa20-25, clone DO-1) for IHC, WB/Western, IP, ELISA LS-C11553 has an LSBio Rating of
Publications (4)

Publications (1)

Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. Shao LN, Zhu BS, Xing CG, Yang XD, Young W, Cao JP. Molecular medicine reports. 2016 13:2661-70. (WB; Human)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 5/25/2022