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TP53 / p53

tumor protein p53

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Gene Name: tumor protein p53
Family/Subfamily: P53 , Not assigned-Other
Synonyms: TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1
Target Sequences: NM_000546 NP_000537.3 P04637

Publications (9)

1
Cancer. p53, guardian of the genome. Lane DP. Nature. 1992 358:15-6. [PubMed:1614522] Related Antibodies: LS-B431.
2
p53 mutations in human cancers. Hollstein M, Sidransky D, Vogelstein B, Harris CC. Science (New York, N.Y.). 1991 253:49-53. [PubMed:1905840] Related Antibodies: LS-B431.
3
Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens. Gurney EG, Harrison RO, Fenno J. Journal of virology. 1980 34:752-63. [PubMed:6155477] [PMC:PMC288763] Related Antibodies: LS-B431.
4
Immunohistochemistry in diagnostic surgical pathology: contributions of protein life-cycle, use of evidence-based methods and data normalization on interpretation of immunohistochemical stains. Idikio HA. International journal of clinical and experimental pathology. 2009 3:169-76. (IHC) [PubMed:20126585] [PMC:PMC2809997]
5
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. Mandriota SJ, Buser R, Lesne L, Stouder C, Favaudon V, Maechler P, Bna F, Clment V, Regg C, Montesano R, Sappino AP. The Journal of biological chemistry. 2010 285:13092-106. [PubMed:20177072] [PMC:PMC2857118] Related Antibodies: LS-C41085.
6
Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats. Jacquin S, Rincheval V, Mignotte B, Richard S, Humbert M, Mercier O, Londoño-Vallejo A, Fadel E, Eddahibi S. PloS one. 2015 10:e0131940. (ICC; Mouse) [Full Text Article] [PubMed:26121334] [PMC:PMC4488287] Related Antibodies: LS-C63152.
7
Stabilization of HIF-1a and HIF-2a, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model. Malchenko S, Sredni ST, Bi Y, Margaryan NV, Boyineni J, Mohanam I, Tomita T, Davuluri RV, Soares MB. PloS one. 2017 12:e0173106. (IHC, WB; Mouse) [Full Text Article] [PubMed:28249000] [PMC:PMC5332108] Related Antibodies: LS-B7722.
8
Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. Shao LN, Zhu BS, Xing CG, Yang XD, Young W, Cao JP. Molecular medicine reports. 2016 13:2661-70. (WB; Human) [Full Text Article] [PubMed:26821367] Related Antibodies: LS-C11553.
9
Clarifying the biological significance of the CHK2 K373E somatic mutation discovered in The Cancer Genome Atlas database. Higashiguchi M, Nagatomo I, Kijima T, Morimura O, Miyake K, Minami T, Koyama S, Hirata H, Iwahori K, Takimoto T, Takeda Y, Kida H, Kumanogoh A. FEBS letters. 2016 December;590:4275-4286. (Human) [Full Text Article] [PubMed:27716909] Related Antibodies: LS-C178095.
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No (691)
Yes (6)
TP53 / p53 Antibody - Anti-TP53 / p53 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TP53 / p53 Mouse anti-Human Monoclonal (BP53-12) Antibody
Human
ChrIP, ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
TP53 / p53 Antibody - Anti-p53 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Select
Cancer Pathology
Cancer
TP53 / p53 Rabbit anti-Human Polyclonal (aa283-332) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Select
TP53 / p53 Mouse anti-Human Monoclonal (aa20-25) (DO-1) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$368
TP53 / p53 Antibody - Western blot of Di-Methyl-p53 (K370) antibody
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TP53 / p53 Rabbit anti-Human Polyclonal (di-methylation site of K370) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
TP53 / p53 Antibody - Immunohistochemistry of paraffin-embedded rat ovary tissue.
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TP53 / p53 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
20 µl/$277; 50 µl/$319; 100 µl/$397; 200 µl/$499
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TP53 / p53 Mouse anti-Human Monoclonal (aa181-190) (DO-11) Antibody
Human
IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$412
TP53 / p53 Antibody - Colon carcinoma stained with anti-p53 antibody
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TP53 / p53 Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
0.25 ml/$383
TP53 / p53 Antibody - Anti-TP53 / p53 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TP53 / p53 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Sheep, Bovine, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TP53 / p53 Antibody - Western blot analysis of UV-treated HEK 293 cell lysates using p53 Antibody (6F2D3), mAb, Mouse. The signal was developed with IRDye™ 800 Conjugated Goat Anti-Mouse IgG. Predicted Size: 53 KD Observed Size: 53 KD
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TP53 / p53 Mouse anti-Human Monoclonal (6F2D3) Antibody
ELISA, Flo, WB
Unconjugated
40 µg/$285
TP53 / p53 Antibody - Anti-TP53 / p53 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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TP53 / p53 Rabbit anti-Human Polyclonal (Acetyl-Lys379) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
Select
TP53 / p53 Mouse anti-Mouse Monoclonal (PAb 122) Antibody
Mouse, Rat, Human
ICC, IHC, IP, WB
Unconjugated
50 µg/$354; 200 µg/$521
TP53 / p53 Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-TP53 mouse monoclonal antibody.
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TP53 / p53 Mouse anti-Human Monoclonal (OTI3A6) Antibody
Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
TP53 / p53 Antibody - Anti-TP53 / p53 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TP53 / p53 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TP53 / p53 Antibody - IHC of p-P53 (S20) pAb in paraffin-embedded human breast carcinoma tissue.
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TP53 / p53 Rabbit anti-Human Polyclonal (pSer20) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$409
TP53 / p53 Antibody - Anti-p53 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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TP53 / p53 Rabbit anti-Human Polyclonal (aa344-393) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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TP53 / p53 Mouse anti-Human Monoclonal (N-Terminus) (Bp53.11) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
50 µg/$548
TP53 / p53 Antibody - MCF-7 cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with monoclonal anti-p53 (clone BP53-12) antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection
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TP53 / p53 Mouse anti-Human Monoclonal (BP53-12) Antibody
Human, Primate
ELISA, ICC, IHC, IHC-P, IP, WB
Unconjugated
25 µg/$256; 100 µg/$321
TP53 / p53 Antibody - Western blot of Anti-p53 clone. X77 antibody at 10 ug/ml on HCT116 cell lysate (1), HCT116 cell lysate activated with Adriamycin (2), p21-/- cell lysate (3), P21-/- cell lysate activated with ADR (4) and p53-/- activated with ADR. ADR activates p53 in cells. Also shown is a graphic representation of the epitope location.
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TP53 / p53 Mouse anti-Human Monoclonal (aa16-30) Antibody
Xenopus, Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$421
TP53 / p53 Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-TP53 mouse monoclonal antibody.
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TP53 / p53 Mouse anti-Human Monoclonal (OTI5E2) Antibody
Mouse, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
TP53 / p53 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
TP53 / p53 Rabbit anti-Human Polyclonal (pSer20) Antibody
Rabbit, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TP53 / p53 Antibody - SP2/0 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TP53 / p53 Rabbit anti-Mouse Polyclonal (aa281-330) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
100 µl/$387
TP53 / p53 Antibody - IHC: Formalin-fixed, paraffin-embedded human bladder carcinoma stained with TP53 antibody (TRP/816). Required HIER: boil tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
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TP53 / p53 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TRP/816) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$550
Select
TP53 / p53 Mouse anti-Mouse Monoclonal (PAb240) Antibody
Chicken, Bovine, Rat, Hamster, Mouse, Human
Flo, IHC, WB
Unconjugated
100 µg/$376
TP53 / p53 Antibody - Flow cytometry of TP53 / p53 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
TP53 / p53 Mouse anti-Mouse Monoclonal (Biotin) (PAb240) Antibody
Chicken, Bovine, Rat, Hamster, Mouse, Human
Flo, IHC, WB
Biotin Conjugated
100 µg/$411
TP53 / p53 Antibody - IHC of p-p53 (S15) pAb in paraffin-embedded human breast carcinoma tissue.
Select
TP53 / p53 Rabbit anti-Human Polyclonal (pSer15) Antibody
Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$409
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).