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ITGAV/Integrin Alpha V/CD51 Antibody (clone RMV‑7) LS‑C57970

Catalog Number Size Price
LS-C57970-250 250 µg (1 mg/ml) $355 
Antibody

ITGAV/Integrin Alpha V/CD51 Antibody (clone RMV‑7) LS‑C57970

Note: This antibody replaces LS-C57973, LS-C44882
Antibody:
Rat Monoclonal to Mouse ITGAV/Integrin Alpha V/CD51
Application:
IHC, IHC-Fr, IP, Flo
Reactivity:
Mouse
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$355 
LS-C57970-250
Toll Free North America
866-819-4732

Overview

Antibody:
Rat Monoclonal to Mouse ITGAV/Integrin Alpha V/CD51
Application:
IHC, IHC-Fr, IP, Flo
Reactivity:
Mouse
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CD51 antibody LS-C57970 is an unconjugated rat monoclonal antibody to mouse CD51 (ITGAV / Integrin Alpha V). Validated for Flow, IHC and IP. Cited in 2 publications.
Target
Mouse ITGAV/Integrin Alpha V/CD51
Host
Rat
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Clone
RMV-7
Conjugations
Unconjugated. Also available conjugated with RPE.
Purification
Affinity purified
Modifications
Unmodified. Also available Low Endotoxin.
Applications
  • IHC
  • IHC - Frozen (1:25 - 1:100)
  • Immunoprecipitation
  • Flow Cytometry (1:25 - 1:100)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Cultured LAK cells from Balb/c mice
Specificity
Recognizes murine CD51, a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 function as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.
Usage
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ITGAV/Integrin Alpha V/CD51
P06756 NM_002210 NP_002201.1

Publications (2)

Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP. Theranostics. 2015 5:515-29. (IP; Mouse)

Pulmonary pericytes regulate lung morphogenesis. Kato K, Diéguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH. Nature communications. 2018 June;9:2448. (Mouse)

Reviews (0)

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Requested From: United States
Date Requested: 9/19/2019