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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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ITGAV/Integrin Alpha V/CD51

integrin, alpha V

ITGAV/Integrin Alpha V/CD51 is a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes.

Gene Name: integrin, alpha V
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGAV, CD51, CD51 antigen, Integrin, alpha V, MSK8, Integrin Alpha V, Integrin alpha-V, VNRA, Vitronectin receptor, Integrin alphaVbeta3, VTNR
Target Sequences: NM_002210 NP_002201.1 P06756

Publications (5)

1
Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells. Defilippi P, van Hinsbergh V, Bertolotto A, Rossino P, Silengo L, Tarone G. The Journal of cell biology. 1991 114:855-63. [PubMed:1869591] [PMC:PMC2289904] Related Antibodies: LS-C41083.
2
Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow. Burdick MM, McCaffery JM, Kim YS, Bochner BS, Konstantopoulos K. American journal of physiology. Cell physiology. 2003 284:C977-87. [PubMed:12477667] Related Antibodies: LS-C41083.
3
Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP. Theranostics. 2015 5:515-29. (IP; Mouse) [Full Text Article] [PubMed:25767618] [PMC:PMC4350013] Related Antibodies: LS-C57970.
4
Pulmonary pericytes regulate lung morphogenesis. Kato K, Diéguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH. Nature communications. 2018 June;9:2448. (Mouse) [Full Text Article] [PubMed:29934496] [PMC:PMC6015030] Related Antibodies: LS-C57970.
5
Tumour exosome integrins determine organotropic metastasis. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn. Nature. 2015 November;527:329-35. [Full Text Article] [PubMed:26524530] [PMC:PMC4788391]
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Viewing 1-25 of 101 items
ITGAV/Integrin Alpha V/CD51 Antibody - Anti-CD51 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
ITGAV/Integrin Alpha V/CD51 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   2.91mg/ml   $425.00
ITGAV/Integrin Alpha V/CD51 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
Select
Rat Monoclonal [clone RMV-7] (IgG1) to Mouse ITGAV/Integrin Alpha V/CD51
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
0.25mg   1mg/ml   $395.00
Select
Rat Monoclonal [clone RMV-7] (IgG1) to Mouse ITGAV/Integrin Alpha V/CD51
Mouse
Flo, IP
Unconjugated, Low Endotoxin
0.5mg   $590.00
ITGAV/Integrin Alpha V/CD51 Antibody - Human melanoma cell line M21 stained with purified NKI-M9, followed by anti-mouse IgG FITC
Select
Mouse Monoclonal [clone NKI-M9] (IgG2a) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, IP
Unconjugated
100µg   0.5mg/ml   $225.00
Select
Mouse Monoclonal (IgG1,k) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, IHC, IHC-Fr, IP
Biotin Conjugated
100µg   $495.00
ITGAV/Integrin Alpha V/CD51 Antibody - Western Blot; Sample: Lane1: Human A549 Cells; Lane2: Human Hela Cells.
Select
Rabbit Polyclonal to Mouse ITGAV/Integrin Alpha V/CD51
Mouse, Human
WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $295.00; 500µl   0.5mg/ml   $435.00; 1ml   0.5mg/ml   $515.00
ITGAV/Integrin Alpha V/CD51 Antibody - Immunohistochemistry image of paraffin-embedded human glioma cancer at a dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   3.29mg/ml   $385.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
Func, IF, IHC, IHC-Fr, IP
Unconjugated
100µg   1mg/ml   $495.00
Select
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Mouse, Goat, Sheep, Pig, Horse, Human
ELISA, IHC, IHC-Fr, IP, RIA, WB
Unconjugated
100µl   $665.00
Select
Mouse Monoclonal [clone P2W7] (IgG1,k) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo
FITC Conjugated
120tst   $345.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, ICC, IHC, IP
Unconjugated
100µg   $680.00
Select
Mouse-Balb/c Monoclonal [clone NKI-M9 (former PAF2a)] (IgG2a) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.1mg   $385.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, ICC, IHC, IP
Unconjugated
100µg   $680.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
HRP Conjugated
100µl   $860.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
Biotin Conjugated
100µl   $860.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
FITC Conjugated
100µl   $860.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
PE Conjugated
100µl   $860.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
APC Conjugated
100µl   $860.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, ICC, IHC, IP
AP Conjugated
100µl   $860.00
Select
Mouse Monoclonal [clone NKI-M7 (former AMF7)] (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated
0.1mg   $385.00
Select
Rat Monoclonal [clone RMV-7] (IgG1) to Mouse ITGAV/Integrin Alpha V/CD51
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
100µg   $515.00; 250µg   $710.00
Select
Mouse Monoclonal [clone 23C6] (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, IHC, IHC-Fr, IP
Unconjugated, Concentrated
200µg   $860.00
Select
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100µg   $455.00

Viewing 1-25 of 101 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).