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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ITGAV/Integrin Alpha V/CD51

integrin, alpha V

ITGAV/Integrin Alpha V/CD51 is a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes.

Gene Name: integrin, alpha V
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGAV, CD51, CD51 antigen, Integrin, alpha V, MSK8, Integrin Alpha V, Integrin alpha-V, VNRA, Vitronectin receptor, Integrin alphaVbeta3, VTNR
Target Sequences: NM_002210 NP_002201.1 P06756

Publications (5)

1
Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells. Defilippi P, van Hinsbergh V, Bertolotto A, Rossino P, Silengo L, Tarone G. The Journal of cell biology. 1991 114:855-63. [PubMed:1869591] [PMC:PMC2289904] Related Antibodies: LS-C41083.
2
Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow. Burdick MM, McCaffery JM, Kim YS, Bochner BS, Konstantopoulos K. American journal of physiology. Cell physiology. 2003 284:C977-87. [PubMed:12477667] Related Antibodies: LS-C41083.
3
Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP. Theranostics. 2015 5:515-29. (IP; Mouse) [Full Text Article] [PubMed:25767618] [PMC:PMC4350013] Related Antibodies: LS-C57970.
4
Pulmonary pericytes regulate lung morphogenesis. Kato K, Diéguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH. Nature communications. 2018 June;9:2448. (Mouse) [Full Text Article] [PubMed:29934496] [PMC:PMC6015030] Related Antibodies: LS-C57970.
5
Tumour exosome integrins determine organotropic metastasis. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn. Nature. 2015 November;527:329-35. [Full Text Article] [PubMed:26524530] [PMC:PMC4788391]
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Filtered by: None
Target
ITGAV/Integrin Alpha V/CD51 (106)
Reactivity
Human (93)
Mouse (38)
Rat (10)
Bovine (4)
Chicken (5)
Chimpanzee (3)
Dog (4)
Drosophila (4)
Gibbon (3)
Goat (5)
Guinea pig (4)
Horse (5)
Monkey (4)
Orangutan (3)
Pig (6)
Rabbit (4)
Sheep (1)
Application
IHC (49)
IHC-Fr (14)
IHC-P (8)
WB (50)
Flo (46)
ELISA (16)
Func (4)
ICC (16)
IF (7)
IP (28)
Peptide-ELISA (2)
RIA (1)
Host
rabbit (53)
mouse (39)
mouse-balb/c (1)
rat (13)
Isotype
IgG (24)
IgG1 (39)
IgG1,k (10)
IgG2a (2)
IgG2a,k (1)
Clonality
monoclonal mc (52)
polyclonal pc (54)
Clone
13C2 (3)
23C6 (1)
G1/G1-4 (1)
NKI-M7 (former AMF7) (1)
NKI-M9 (4)
NKI-M9 (former PAF2a) (1)
P2W7 (5)
RMV-7 (8)
Format
AP Conjugated (4)
APC (2)
APC Conjugated (5)
Azide-free (1)
Biotin Conjugated (11)
Concentrated (1)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (12)
HRP Conjugated (8)
Low Endotoxin (1)
PE Conjugated (9)
RPE Conjugated (2)
Unconjugated (51)
Epitope
C-Terminus (8)
aa560-744 (8)
aa71-322 (8)
Internal (2)
810-890 aa, C-terminal (1)
Pro804 (1)
aa1028-1048 (1)
aa755-804 (1)
aa840-889 (1)
Publications
No (104)
Yes (2)
Showing 1-25 of 106 results

IHC-plus™ ITGAV/Integrin Alpha V/CD51 Antibody (aa840-889) LS-B5254
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-CD51 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-CD51 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

ITGAV/Integrin Alpha V/CD51 Antibody (clone RMV-7) LS-C57970
Publications (2)
Publications (2)
Rat Monoclonal [clone RMV-7] (IgG1) to Mouse ITGAV/Integrin Alpha V/CD51
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
250µg 1mg/ml  $355.00

ITGAV/Integrin Alpha V/CD51 Antibody (clone RMV-7, Low Endotoxin) LS-C44881
Rat Monoclonal [clone RMV-7] (IgG1) to Mouse ITGAV/Integrin Alpha V/CD51
Mouse
Flo, IP
Unconjugated, Low Endotoxin
0.5mg  $590.00

ITGAV/Integrin Alpha V/CD51 Antibody (clone NKI-M9) LS-C41083
Publications (2)
Publications (2)
Mouse Monoclonal [clone NKI-M9] (IgG2a) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, IP
Unconjugated
100µg 0.5mg/ml  $225.00
Human melanoma cell line M21 stained with purified NKI-M9, followed by anti-mouse IgG FITC

ITGAV/Integrin Alpha V/CD51 Antibody (aa1028-1048) LS-C312571
Rabbit Polyclonal to Human ITGAV/Integrin Alpha V/CD51
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
ITGAV/Integrin Alpha V/CD51 antibody. IHC(P): Human Breast Cancer Tissue.
ITGAV/Integrin Alpha V/CD51 antibody. ICC: A549 Cell.

ITGAV/Integrin Alpha V/CD51 Antibody (clone RMV-7, PE) LS-C106287
Rat Monoclonal [clone RMV-7] (IgG1,k) to Mouse ITGAV/Integrin Alpha V/CD51
Mouse
Flo
PE Conjugated
50µg 0.2mg/ml  $225.00; 100µg 0.5mg/ml  $305.00; 200µg  $385.00
Staining of BALB/c splenocytes with staining buffer (autofluorescence) (open histogram) or 0.25 ug PE anti-mouse CD51 (RMV-7) (colored histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

ITGAV/Integrin Alpha V/CD51 Antibody (Biotin) LS-C35659
Mouse Monoclonal (IgG1,k) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, IHC, IHC-Fr, IP
Biotin Conjugated
100µg  $495.00

ITGAV/Integrin Alpha V/CD51 Antibody (aa71-322) LS-C374097
Rabbit Polyclonal to Mouse ITGAV/Integrin Alpha V/CD51
Mouse, Human
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $515.00
Western Blot; Sample: Lane1: Human A549 Cells; Lane2: Human Hela Cells.
Western Blot; Sample: Recombinant ITGaV, Mouse.

ITGAV/Integrin Alpha V/CD51 Antibody LS-C671372
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg  $285.00; 100µg 3.29mg/ml  $385.00
Immunohistochemistry image of paraffin-embedded human glioma cancer at a dilution of 1:100
Immunohistochemistry image of paraffin-embedded human kidney tissue at a dilution of 1:100

ITGAV/Integrin Alpha V/CD51 Antibody (C-Terminus) LS-C13742
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Mouse, Goat, Sheep, Pig, Horse, Human
ELISA, IHC, IHC-Fr, IP, RIA, WB
Unconjugated
100µl  $665.00

IHC-plus™ ITGAV/Integrin Alpha V/CD51 Antibody LS-B11920
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot analysis of extracts of various cell lines, using ITGAV antibody.

ITGAV/Integrin Alpha V/CD51 Antibody (Pro804) LS-C177573
Rabbit Polyclonal to Human ITGAV/Integrin Alpha V/CD51
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of Integrin V (P804) pAb in paraffin-embedded human brain tissue.
Western blot of Integrin V (P804) pAb in extracts from HeLa cells.

ITGAV/Integrin Alpha V/CD51 Antibody (clone P2W7, FITC) LS-C134480
Mouse Monoclonal [clone P2W7] (IgG1,k) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo
FITC Conjugated
120tst  $345.00

IHC-plus™ ITGAV/Integrin Alpha V/CD51 Antibody (aa755-804) LS-B12556
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl 1mg/ml  $505.00
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

ITGAV/Integrin Alpha V/CD51 Antibody (clone NKI-M9 (former PAF2a)) LS-C150543
Mouse-Balb/c Monoclonal [clone NKI-M9 (former PAF2a)] (IgG2a) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.1mg  $375.00

ITGAV/Integrin Alpha V/CD51 Antibody LS-C13737
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, ICC, IHC, IP
Unconjugated
100µg  $680.00

ITGAV/Integrin Alpha V/CD51 Antibody LS-C13738
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
Flo, ICC, IHC, IP
Unconjugated
100µg  $680.00

ITGAV/Integrin Alpha V/CD51 Antibody (HRP) LS-C544586
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
HRP Conjugated
100µl  $860.00

ITGAV/Integrin Alpha V/CD51 Antibody (Biotin) LS-C524462
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
Biotin Conjugated
100µl  $860.00

ITGAV/Integrin Alpha V/CD51 Antibody (FITC) LS-C534481
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
FITC Conjugated
100µl  $860.00

ITGAV/Integrin Alpha V/CD51 Antibody (APC) LS-C515725
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
APC Conjugated
100µl  $860.00

ITGAV/Integrin Alpha V/CD51 Antibody (PE) LS-C652669
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, ICC, IHC, IP
PE Conjugated
100µl  $860.00

ITGAV/Integrin Alpha V/CD51 Antibody (clone NKI-M7 (former AMF7)) LS-C347518
Mouse Monoclonal [clone NKI-M7 (former AMF7)] (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated
0.1mg  $375.00

ITGAV/Integrin Alpha V/CD51 Antibody LS-C152897
Mouse Monoclonal (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human
Func, IF, IHC, IHC-Fr, IP
Unconjugated
100µg 1mg/ml  $495.00

ITGAV/Integrin Alpha V/CD51 Antibody (clone RMV-7) LS-C123062
Rat Monoclonal [clone RMV-7] (IgG1) to Mouse ITGAV/Integrin Alpha V/CD51
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
100µg  $515.00; 250µg  $710.00
Showing 1-25 of 106 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).