Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Catalog Number Size Price
LS-C44980-0.1 0.1 mg (1 mg/ml) $644 
Antibody

Monoclonal Mouse anti‑Human CLU / Clusterin Antibody (clone 3R3/2, IHC, WB) LS‑C44980

Monoclonal Mouse anti‑Human CLU / Clusterin Antibody (clone 3R3/2, IHC, WB) LS‑C44980

Antibody:
CLU / Clusterin Mouse anti-Human Monoclonal (3R3/2) Antibody
Application:
IHC, IHC-Fr, WB, Flo, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$644
LS-C44980-0.1
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CLU / Clusterin Mouse anti-Human Monoclonal (3R3/2) Antibody
Application:
IHC, IHC-Fr, WB, Flo, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Clusterin antibody LS-C44980 is an unconjugated mouse monoclonal antibody to human Clusterin (CLU). Validated for ELISA, Flow, IHC and WB. Cited in 1 publication.
Target
Human CLU / Clusterin
Synonyms
CLU | APO-J | Apolipoprotein J | CLU1 | Clusterin | Complement lysis inhibitor | CLI | AAG4 | Aging-associated protein 4 | Ku70-binding protein 1 | KUB1 | SGP2 | APOJ | SGP-2 | Sulfated glycoprotein 2 | CLU2 | Complement cytolysis inhibitor | NA1/NA2 | SP-40
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Clone
3R3/2
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Immunogen
Glomerular basement membrane from a post-mortem kidney.
Specificity
Recognizes clusterin, an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localized to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitize cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.
Applications
  • IHC
  • IHC - Frozen
  • Western blot
  • Flow Cytometry
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
BBS, 0.1% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CLU / Clusterin
P10909 NM_001831 NP_001822.3

LSBio Ratings

CLU / Clusterin Antibody (clone 3R3/2) for IHC, WB/Western, Flow, ELISA LS-C44980 has an LSBio Rating of
Publications (4)

Publications (1)

Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. Yang Y, Keene CD, Peskind ER, Galasko DR, Hu SC, Cudaback E, Wilson AM, Li G, Yu CE, Montine KS, Zhang J, Baird GS, Hyman BT, Montine TJ. Journal of neuropathology and experimental neurology. 2015 74:672-87. (WB; Human)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 5/23/2022