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CLU / Clusterin

clusterin

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Gene Name: clusterin
Synonyms: CLU, APO-J, Apolipoprotein J, CLU1, Clusterin, Complement lysis inhibitor, CLI, AAG4, Aging-associated protein 4, Ku70-binding protein 1, KUB1, SGP2, APOJ, SGP-2, Sulfated glycoprotein 2, CLU2, Complement cytolysis inhibitor, NA1/NA2, SP-40
Target Sequences: NM_001831 NP_001822.3 P10909

Publications (4)

1
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. Yang Y, Keene CD, Peskind ER, Galasko DR, Hu SC, Cudaback E, Wilson AM, Li G, Yu CE, Montine KS, Zhang J, Baird GS, Hyman BT, Montine TJ. Journal of neuropathology and experimental neurology. 2015 74:672-87. (WB; Human) [Full Text Article] [PubMed:26083568] [PMC:PMC4471879] Related Antibodies: LS-C44980.
2
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury. Das Gupta S, Lipponen A, Paldanius KMA, Puhakka N, Pitkänen A. Science advances. 2019 December;9:20208. [Full Text Article] [PubMed:31882899] [PMC:PMC6934775]
3
Early Elevation of Systemic Plasma Clusterin after Reperfused Acute Myocardial Infarction in a Preclinical Porcine Model of Ischemic Heart Disease. Denise Traxler, Andreas Spannbauer, Patrick Einzinger, Julia Mester-Tonczar, Dominika Lukovic, Johannes Winkler, Katrin Zlabinger, Alfred Gugerell, LJubica Mandic, Mariann Gyöngyösi, Noemi Pavo. International journal of molecular sciences. 2020 June;21: [Full Text Article] [PubMed:32605184] [PMC:PMC7369988]
4
Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis. Marietta Armaka, Dimitris Konstantopoulos, Christos Tzaferis, Matthieu D Lavigne, Maria Sakkou, Anastasios Liakos, Petros P Sfikakis, Meletios A Dimopoulos, Maria Fousteri, George Kollias. Genome medicine. 2022 July;14:78. [Full Text Article] [PubMed:35879783] [PMC:PMC9316748]
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Antibodies (197)
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CLU / Clusterin (197)
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No (196)
Yes (1)
CLU / Clusterin Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CLU / Clusterin Goat anti-Human Polyclonal (aa488-501) Antibody
Human, Monkey
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Select
CLU / Clusterin Mouse anti-Human Monoclonal (3R3/2) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$533
CLU / Clusterin Antibody - CLU / Clusterin antibody immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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CLU / Clusterin Goat anti-Mouse Polyclonal (aa435-448) Antibody
Mouse, Rat
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
Select
CLU / Clusterin Mouse anti-Human Monoclonal (aa75-501) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
250 µg/$1,068
Select
CLU / Clusterin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
500 µg/$634
CLU / Clusterin Antibody - Anti-Clusterin antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CLU / Clusterin Mouse anti-Human Monoclonal (Hs-3) Antibody
Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CLU / Clusterin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CLU / Clusterin Rabbit anti-Human Polyclonal (Glu436) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CLU / Clusterin Antibody - Anti-Clusterin antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CLU / Clusterin Mouse anti-Human Monoclonal (aa1-333) (1A11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Select
CLU / Clusterin Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
100 µl/$1,144
CLU / Clusterin Antibody - Anti-Clusterin antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CLU / Clusterin Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$485
CLU / Clusterin Antibody - Detection limit for recombinant GST tagged CLU is approximately 0.1 ng/ml as a capture antibody.
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CLU / Clusterin Mouse anti-Human Monoclonal (1A11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Select
CLU / Clusterin Mouse anti-Human Monoclonal Antibody
Human
ELISA, ICC, IF, IHC, WB
Unconjugated
100 µg/$638
CLU / Clusterin Antibody - Western blot of Clusterin antibody
Select
CLU / Clusterin Rabbit anti-Human Polyclonal (370-450 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
CLU / Clusterin Mouse anti-Human Monoclonal (CLI-9) Antibody
Human
ICC, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$490
Select
CLU / Clusterin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
500 µg/$994
CLU / Clusterin Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-CLU mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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CLU / Clusterin Mouse anti-Human Monoclonal (aa23-227) (OTI5D3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
CLU / Clusterin Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLU / Clusterin Rabbit anti-Human Polyclonal (aa71-99) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$485
CLU / Clusterin Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CLU / Clusterin Rabbit anti-Human Polyclonal (aa71-99) (APC) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
APC Conjugated
200 µl/$952
CLU / Clusterin Antibody - Western blot analysis using anti-Clusterin (mouse), pAb at 1:2000 dilution. 1: Mouse serum (2 ul). 4: Mouse seminal plasma. 5: Mouse Clusterin (nuclear form) (His-tagged).
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CLU / Clusterin Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$323
CLU / Clusterin Antibody - Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 10 ug/ml.
Select
CLU / Clusterin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
Select
CLU / Clusterin Mouse anti-Human Monoclonal (s-3) Antibody
Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1 mg/$386
Select
CLU / Clusterin Mouse anti-Human Monoclonal (aa75-501) Antibody
Human
ELISA
Unconjugated
100 µg/$930; 500 µg/$1,795
Select
CLU / Clusterin Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
0.1 mg/$386
Select
CLU / Clusterin Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF, WB
Unconjugated
100 µl/$412
Select
CLU / Clusterin Rabbit anti-Mouse Monoclonal (Preservative Free) (102) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
Viewing 1-25 of 197 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).