Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 4H9] (IgG2a) to Human TP53 / p53
IHC, Western blot, Immunoprecipitation, ELISA
Human TP53 / p53
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [4H9]
Protein G purified
Specificity and Use
TP53 / p53 antibody was raised against recombinant human p53 expressed in E. coli.
an epitope within aa 20-25 at the N-terminus of human p53. p53 is a nuclear protein and tumor suppressor that is mutated in a wide variety of cancers. It mediates cell cycle arrest in response to DNA damage, making it important in the maintenance of genomic stability
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases.