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Anti-TP53 / p53 Antibody (aa20-25) LS-C43564

Ordering

Wt. Vol. Conc. Price
- 1000 µl - $235
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular TP53 / p53 Antibodies

Anti-TP53 / p53 Antibody (clone BP53-12) IHC-plus™ LS-B431
Mouse Monoclonal [clone BP53-12] (IgG2a,k) to Human TP53 / p53
Human
IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image
Anti-TP53 / p53 Antibody (clone PAb240, Azide-free) LS-C87442
Mouse Monoclonal [clone PAb240] (IgG1) to Mouse TP53 / p53
Mouse, Human
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated, Azide-free
Immunohistochemistry Image
Anti-TP53 / p53 Antibody (clone 6F2D3) LS-C203312
Mouse Monoclonal [clone 6F2D3] (IgG1) to Human TP53 / p53
Human
Western blot, Flow Cytometry, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG2b) to Human TP53 / p53
Human, Bovine
IHC - Paraffin, IHC - Frozen
Unconjugated

Details

Human TP53 / p53
Mouse
Human, Bovine (tested or 100% immunogen sequence identity)
Mouse, Rat
IgG2b Monoclonal
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (1:1)
  • IHC - Frozen (1:1)

Specificity and Use

TP53 / p53 antibody was raised against recombinant human p53 ( AA 20-25 ).
aa20-25
Recognizes the human 53kD p53 tumor suppressor protein, also known as Cellular tumor antigen p53 or Antigen NY-CO-13, encoded by the TP53 gene. p53 is a 393 amino acid protein with an N-terminal transactivation domain, followed by a proline-rich region and a DNA binding domain in the central core region. The C-terminal region contains a tetramerization domain and a terminal regulatory domain. p53 is intimately involved in a number of signaling pathways controlling cell division, cycling and apoptosis and is thus a potent cancer suppressor. In normal cells the level of p53 expression is low but can be induced by DNA damage or other stress signals. Activation of p53 leads to growth arrest through its interaction with p21, GADD45 and, DNA repair and potentially apoptosis through interaction with,, and. p53 is critically regulated by Mdm2 which can trigger p53 degradation by a ubiquitin dependent systemrecognizes an epitope at the N-terminal end of p53 between amino acids 20-25, binding to both wild type and mutant forms. Clone DO-7 is not expected to recognize the multiple lacking the N-terminal region.
Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.

Packaging

PBS, pH 7.4, 0.09% sodium azide, 1% BSA.
For research use only.

About TP53 / p53

P04637 NM_000546 NP_000537.3

TP53 Antibody, BCC7 Antibody, Cellular tumor antigen p53 Antibody, p53 Antibody, TRP53 Antibody, p53 tumor suppressor Antibody, Phosphoprotein p53 Antibody, Antigen NY-CO-13 Antibody, Tumor protein p53 Antibody, Tumor suppressor p53 Antibody, LFS1 Antibody

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases.

Immunohistochemistry

Immunohistochemistry
p53 - LS-C43564 - Human breast carcinoma. Formalin-fixed, paraffin processed tissue.
 

Requested From: United States
Date Requested: 12/8/2016

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