Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human TGM2 / Transglutaminase 2
Human, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation
Goat Polyclonal to Human TGM2 / Transglutaminase 2
Western blot, ELISA
Human TGM2 / Transglutaminase 2
Human, Monkey (tested or 100% immunogen sequence identity)
Bovine, Rabbit (at least 90% immunogen sequence identity)
Western blot (0.05 - 0.2 µg/ml)
Specificity and Use
Synthetic peptide C-ESDKLKAVKGFRN from the C-terminus of human TGM2 / Transglutaminase 2 (NP_004604.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Panda (100%); Ferret, Bovine, Rabbit (92%); Elephant, Guinea pig, Lizard, Xenopus (85%); Mouse, Rat (69%).
Human TGM2 / Transglutaminase 2. This antibody is expected to recognise isoform a (NP_004604.2) only.
Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 80kD band observed in Human Pancreas cancer lysates (calculated MW of 77.3kD according to NP_004604.2). Recommended concentration: 0.05-0.2 ug/ml.
TGM2 Antibody, G-ALPHA-h Antibody, GNAH Antibody, TG(C) Antibody, Transglutaminase 2 Antibody, Transglutaminase C Antibody, TG2 Antibody, TGase H Antibody, TGase-2 Antibody, TGase-H Antibody, Transglutaminase H Antibody, TGase C Antibody, TGC Antibody, TTG Antibody, C polypeptide Antibody, Tgase II Antibody, Tissue transglutaminase Antibody, Transglutaminase-2 Antibody
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease.