Target
Mouse ITGAV/Integrin Alpha V/CD51
Synonyms
ITGAV | CD51 | CD51 antigen | Integrin, alpha V | MSK8 | Integrin Alpha V | Integrin alpha-V | VNRA | Vitronectin receptor | Integrin alphaVbeta3 | VTNR
Reactivity
Mouse
(tested or 100% immunogen sequence identity)
Modifications
Low Endotoxin.
Also available
Unmodified.
Immunogen
Cultured LAK cells from Balb/c mice
Specificity
Recognizes murine CD51, a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 functions as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.