Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [12G5]
Specificity and Use
CXCR4 antibody was raised against sIV-infected SupT1 cells injected into Balb/c mice.
For use in flow cytometry and immunohistochemical analyses of the CXCR4 receptor in human celllines and tissues. Fixation with methanol and/or acetone was shown to destroy the epitope of the12G5 mAb. 12G5 can be used to block SDF-1-induced chemotaxis and increases of intracellularcalcium. The optimal antibody concentration should be determined for each specific application.
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation.