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Anti-CXCR4 Antibody (clone 12G5) IHC-plus™ LS-B1986

Note: This antibody replaces LS-C41092
Catalog Size Price
LS-B1986-50 50 µg (0.5 mg/ml) Unavailable

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100% Guaranteed Publications (2)
Mouse Monoclonal [clone 12G5] (IgG2a) to Human CXCR4
Human, Baboon, Monkey
IHC - Paraffin, IHC - Frozen, Immunofluorescence, Flow Cytometry


Human CXCR4
Human, Baboon, Monkey (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [12G5]
Affinity purified


  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • Immunofluorescence
  • Flow Cytometry

Specificity and Use

CXCR4 antibody was raised against cP-MAC-infected Sup-T1 cells
Immunohistochemistry: LS-B1986 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1986 was determined to be 10 ug/ml.


PBS, pH 7.2, 0.09% sodium azide. Sourced from tissue culture supernatant.
+4°C, avoid freezing.
For research use only.

Publications (2)

Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. The Journal of biological chemistry. 2007 282:9547-55. [PubMed:17289675] [PMC:PMC2366813]
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E. Blood. 2010 115:5026-36. [PubMed:20231422] [PMC:PMC3373152]

About CXCR4

P61073 NM_003467 NP_003458.1

CXCR4 Antibody, CD184 Antibody, CD184 antigen Antibody, Cmkar4 Antibody, Cxc chemokine receptor 4 Antibody, CXCR-4 Antibody, CXC-R4 Antibody, D2S201E Antibody, FB22 Antibody, Fusin Antibody, HM89 Antibody, LCR1 Antibody, NPY3R Antibody, NPYRL Antibody, NPYY3R Antibody, Npyy3 Antibody, HSY3RR Antibody, SDF-1 receptor Antibody, WHIM Antibody, C-x-c chemokine receptor 4 Antibody, LESTR Antibody, Neuropeptide Y receptor Y3 Antibody, NPYR Antibody

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation.


Anti-CXCR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1986 concentration 10 ug/ml.

Flow Cytometry

Flow Cytometry
Human peripheral blood lymphocytes stained with purified 12G5, followed by biotinylated anti-mouse IgG and Sav-PE

Requested From: 
Date Requested: 3/18/2018

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