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Anti-CLU / Clusterin Antibody (clone 3R3/2) LS-C44980


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $525
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular CLU / Clusterin Antibodies

Anti-CLU / Clusterin Antibody (clone 3R3/2) LS-C44980
Mouse Monoclonal [clone 3R3/2] (IgG1) to Human CLU / Clusterin
IHC - Frozen, Western blot, Flow Cytometry, ELISA
Anti-CLU / Clusterin Antibody (aa75-501, Biotin) LS-C128238
Mouse Monoclonal (IgG2b) to Human CLU / Clusterin
Biotin Conjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 3R3/2] (IgG1) to Human CLU / Clusterin
IHC - Frozen, Western blot, Flow Cytometry, ELISA


Human CLU / Clusterin
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [3R3/2]
Protein A purified


  • IHC - Frozen
  • Western blot
  • Flow Cytometry

Specificity and Use

CLU / Clusterin antibody was raised against glomerular basement membrane from a post-mortem kidney.
Recognizes clusterin, an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localized to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitize cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.


Borate buffered saline, 0.1% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About CLU / Clusterin

P10909 NM_001831 NP_001822.3

CLU Antibody, APO-J Antibody, Apolipoprotein J Antibody, CLU1 Antibody, Clusterin Antibody, Complement lysis inhibitor Antibody, CLI Antibody, AAG4 Antibody, Aging-associated protein 4 Antibody, Ku70-binding protein 1 Antibody, KUB1 Antibody, SGP2 Antibody, APOJ Antibody, SGP-2 Antibody, Sulfated glycoprotein 2 Antibody, CLU2 Antibody, Complement cytolysis inhibitor Antibody, NA1/NA2 Antibody, SP-40 Antibody

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself.

Requested From: United States
Date Requested: 10/23/2016

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