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BAIAP2 / IRSP53 has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene Name: | BAI1-associated protein 2 |
Synonyms: | BAIAP2, BAI-associated protein 2, BAI1-associated protein 2, BAP2, FLAF3, Fas ligand-associated factor 3, IRSP53, IRS-58, Protein BAP2, IRSp53/58 |
Target Sequences: | NM_017450 NP_059344.1 Q9UQB8 |
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