Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

ZAP70

zeta-chain (TCR) associated protein kinase 70kDa

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR).

Gene Name: zeta-chain (TCR) associated protein kinase 70kDa
Family/Subfamily: Protein Kinase , Syk/ZAP70
Synonyms: ZAP70, 70 kDa zeta-associated protein, SRK, STCD, STD, Syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70, TZK, ZAP-70, Zeta-associated protein 70
Target Sequences: NM_207519 P43403 P43403

Publications (2)

1
CD38 gene polymorphisms contribute to genetic susceptibility to B-cell chronic lymphocytic leukemia: evidence from two case-control studies in Polish Caucasians. Jamroziak K, Szemraj Z, Grzybowska-Izydorczyk O, Szemraj J, Bieniasz M, Cebula B, Giannopoulos K, Balcerczak E, Jesionek-Kupnicka D, Kowal M, Kostyra A, Calbecka M, Wawrzyniak E, Mirowski M, Kordek R, Robak T. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009 18:945-53. [PubMed:19240243] Related Antibodies: LS-C40875.
2
GATA-3 regulates the homeostasis and activation of CD8+ T cells. Tai TS, Pai SY, Ho IC. Journal of immunology (Baltimore, Md. : 1950). 2013 190:428-37. [PubMed:23225883] [PMC:PMC3529853] Related Antibodies: LS-C40875.

☰ Filters
Products
Antibodies (194)
Primary (194)
ZAP70 (194)
Human (183)
Mouse (82)
Rat (35)
Bat (4)
Bovine (9)
Chicken (7)
Chimpanzee (3)
Gibbon (6)
Guinea pig (8)
Horse (8)
Monkey (13)
Pig (5)
Rabbit (9)
Xenopus (2)
IHC (79)
IHC-Fr (3)
IHC-P (41)
WB (140)
Flo (41)
ELISA (60)
FLISA (2)
ICC (15)
IF (28)
IP (25)
Peptide-ELISA (11)
rabbit (120)
mouse (71)
goat (2)
sheep (1)
Product Group
IHCPlus (2)
IgG (80)
IgG1 (20)
IgG1,k (15)
IgG2a (13)
IgG2a,k (14)
IgG2b (1)
monoclonal mc (71)
polyclonal pc (123)
11H40 (1)
1475CT217.34.65 (1)
1484CT290.68.62 (1)
1E7.2 (1)
2F3.2 (7)
2F6 (1)
3D2A4 (2)
ABT-ZAP70 (1)
GF1 (1)
Polyclonal (1)
SBZAP (6)
SPM362 (2)
ZAP-03 (2)
ZAP70/2035 (2)
ZAP70/2046 (2)
ZAP70/2047 (2)
ZAP70/528 (3)
ZAP70/528 + 2F3.2 (3)
ZPT70-2 (2)
ZTP70-1 (3)
AP Conjugated (7)
APC (2)
APC Conjugated (7)
Azide-free (12)
Biotin Conjugated (12)
BSA-free (9)
Concentrated (2)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (13)
HRP Conjugated (11)
PE Conjugated (9)
Preservative Free (2)
Ready-to-Use (5)
Unconjugated (131)
pTyr319 (9)
pTyr493 (9)
aa103-130 (8)
aa270-560 (8)
aa276-304 (8)
aa337-600 (8)
aa530-558 (8)
aa280-309 (5)
C-Terminus (4)
aa301-350 (4)
aa52-101 (4)
pTyr315 (4)
pTyr292 (3)
230-310 aa (2)
250-330 aa (2)
260-340 aa (2)
430-510 aa (2)
aa282-307 (2)
Ab-315 (1)
Internal (1)
Ser313 (1)
Thr286 (1)
aa1-254 (1)
aa10-102 (1)
aa163-254 (1)
aa168-421 (1)
aa258-307 (1)
aa281-330 (1)
aa286-335 (1)
aa289-303 (1)
aa326-341 (1)
aa460-509 (1)
aa564-614 (1)
aa71-303 (1)
p292 (1)
pTyr315/Tyr319 (1)
pTyr493/494 (1)
No (193)
Yes (1)
ZAP70 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using ZAP-70 (Phospho-Tyr493) Antibody. The picture on the right is blocked with the phospho peptide.
Select
ZAP70 Rabbit anti-Human Polyclonal (pTyr493) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
ZAP70 Antibody - Jurkat cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with monoclonal anti-ZAP-70 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system.
Select
ZAP70 Mouse anti-Human Monoclonal (aa282-307) (1E7.2) Antibody
Mouse, Human
Flo, IP, WB
Unconjugated
100 µg/$301
ZAP70 Antibody - Immunohistochemical analysis of ZAP70 (pY319) staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
ZAP70 Rabbit anti-Human Polyclonal (pTyr319) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$331
ZAP70 Antibody - Immunohistochemistry analysis of paraffin-embedded human lymph node, using ZAP-70 (Phospho-Tyr315) Antibody. The picture on the right is blocked with the phospho peptide.
Select
ZAP70 Rabbit anti-Human Polyclonal (pTyr315) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
ZAP70 Antibody - Formalin-Fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and AEC chromogen. Note staining of T-Cells.
Select
ZAP70 Mouse anti-Human Monoclonal (2F3.2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$363; 500 µl/$597; 1 ml/$854
ZAP70 Antibody - Anti-ZAP70 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Select
ZAP70 Mouse anti-Human Monoclonal (11H40) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$575
ZAP70 Antibody - 1:200 staining human heart tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
ZAP70 Rabbit anti-Human Polyclonal (pTyr319) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
ZAP70 Antibody - ZAP70 antibody Western Blot of Mouse Kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
ZAP70 Rabbit anti-Mouse Polyclonal (aa301-350) Antibody
Chicken, Rabbit, Mouse, Guinea pig, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µl/$434
ZAP70 Antibody - Immunohistochemical analysis of ZAP70 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
ZAP70 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$311
ZAP70 Antibody - Immunohistochemical analysis of ZAP70 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
ZAP70 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$311
ZAP70 Antibody - 1:200 staining human kidney tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22° C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
ZAP70 Rabbit anti-Human Polyclonal (pTyr493) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP-70 antibody (2F3.2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (2F3.2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$347; 100 µg/$522
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP-70 antibody (2F3.2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (2F3.2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$522
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP-70 antibody (2F3.2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (Ready-to-Use) (2F3.2) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$522
ZAP70 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
ZAP70 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
ZAP70 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
ZAP70 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
Select
ZAP70 Rabbit anti-Human Polyclonal (pTyr319) Antibody
Mouse, Human
Flo, ICC, IF, IP, WB
Unconjugated
100 µl/$611
ZAP70 Antibody - Anti-ZAP70 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
ZAP70 Rabbit anti-Human Polyclonal (aa460-509) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$505
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 antibody (ZAP70/528 + 2F3.2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (ZAP70/528 + 2F3.2) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$347; 100 µg/$522
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 antibody (ZAP70/528 + 2F3.2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (Ready-to-Use) (ZAP70/528 + 2F3.2) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$522
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 antibody (SPM362).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (SPM362) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$347; 100 µg/$522
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 antibody (SPM362).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM362) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$522
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 antibody (ZAP70/528).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (ZAP70/528) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$347; 100 µg/$522
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 antibody (ZAP70/528).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (Ready-to-Use) (ZAP70/528) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$522
ZAP70 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 antibody (ZAP70/528).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ZAP70 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (ZAP70/528) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$522
Viewing 1-25 of 194 product results


Filtered By:
Products: Antibodies


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).