Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

Tuberin / TSC2

tuberous sclerosis 2

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist.

Gene Name: tuberous sclerosis 2
Synonyms: TSC2, LAM, Tuberous sclerosis 2 protein, TSC4, Tuberin, Tuberous sclerosis 2
Target Sequences: NM_000548 NP_000539.2 P49815

Publications (6)

1
The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition. Shiono M, Kobayashi T, Takahashi R, Sun G, Abe M, Zhang D, Wang L, Piao X, Takagi Y, Mineki R, Taka H, Tada N, Sonobe S, Momose S, Ueda M, Hino O. Oncogene. 2008 27:6690-7. (WB) [PubMed:18695678]
2
PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. Blando J, Portis M, Benavides F, Alexander A, Mills G, Dave B, Conti CJ, Kim J, Walker CL. The American journal of pathology. 2009 174:1869-79. (WB) [PubMed:19395652] [PMC:PMC2671275]
3
Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. Miyazaki M, McCarthy JJ, Fedele MJ, Esser KA. The Journal of physiology. 2011 589:1831-46. [PubMed:21300751] [PMC:PMC3099033] Related Antibodies: LS-B1654.
4
Regulation of the mTOR signaling network in hibernating thirteen-lined ground squirrels. Wu CW, Storey KB. The Journal of experimental biology. 2012 215:1720-7. [PubMed:22539739]
5
Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication. Avey D, Tepper S, Li W, Turpin Z, Zhu F. PLoS pathogens. 2015 11:e1004993. (IF; Human) [Full Text Article] [PubMed:26133373] [PMC:PMC4489790] Related Antibodies: LS-C96812.
6
Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation. Bartolom A, Guilln C, Benito M. Endocrinology. 2010 151:3084-94. [PubMed:20427478] Related Antibodies: LS-B1654.
more

☰ Filters
Products
Antibodies (233)
Primary (233)
Tuberin / TSC2 (233)
Human (163)
Mouse (120)
Rat (52)
Bat (1)
Bovine (2)
Dog (1)
Goat (1)
Horse (2)
Monkey (6)
Pig (1)
Rabbit (8)
Sheep (1)
IHC (75)
IHC-P (16)
WB (98)
DB (105)
ELISA (166)
ICC (5)
IF (21)
IP (9)
Peptide-ELISA (11)
rabbit (218)
mouse (15)
Product Group
IHCPlus (5)
IgG (179)
IgG1 (7)
IgG1,k (8)
monoclonal mc (15)
polyclonal pc (218)
1C1 (1)
249CT19.1.3 (7)
TS106 (1)
APC Conjugated (24)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 594 Conjugated (1)
Azide-free (23)
Biotin Conjugated (25)
FITC Conjugated (25)
HRP Conjugated (24)
PE Conjugated (23)
PerCP Conjugated (1)
RPE Conjugated (1)
Unconjugated (107)
pSer1096 (14)
pSer939 (11)
pSer664 (8)
Ser1387 (7)
Ser1798 (7)
aa479-508 (7)
pSer1155 (7)
pSer1343 (7)
pSer1348 (7)
pSer1365 (7)
pSer1388 (7)
pSer1412 (7)
pSer1419 (7)
pSer1420 (7)
pSer1421 (7)
pSer1798 (7)
pThr1373 (7)
pThr1462 (7)
Ser1254 (6)
Ser939 (6)
aa1404-1433 (6)
pTyr1571 (4)
1400-1480 aa (2)
880-960 aa (2)
pSer1254 (2)
1510-1590 aa (1)
920-1000 aa (1)
Ab-1462 (1)
C-Terminus (1)
Internal (1)
Leu1456 (1)
Phe933 (1)
Ser664 (1)
Tyr1571 (1)
aa1-50 (1)
aa1211-1260 (1)
aa1364-1393 (1)
aa1428-1477 (1)
aa1605-1620 (1)
aa1611-1807 (1)
aa1750-C-term (1)
aa550-850 (1)
aa905-954 (1)
aa929-978 (1)
aa947-996 (1)
p939 (1)
p981 (1)
pSer1387 (1)
pSer981 (1)
No (231)
Yes (2)
Tuberin / TSC2 Antibody - Anti-TSC2 / Tuberin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer664) Antibody
Human
ICC, IF, IHC, IHC-P
Unconjugated
50 µl/$460
Tuberin / TSC2 Antibody - Anti-Tuberin / TSC2 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Tuberin / TSC2 Mouse anti-Mouse Monoclonal (249CT19.1.3) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
Tuberin / TSC2 Antibody - Anti-TSC2 / Tuberin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (Ser1798) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$440
Tuberin / TSC2 Antibody - Anti-TSC2 / Tuberin antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
Tuberin / TSC2 Antibody - Immunohistochemical analysis of TSC2 (pS939) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer939) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$315
Tuberin / TSC2 Antibody - Confocal immunofluorescence of Phospho-TSC2-S1798 Antibody with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer1798) Antibody
Human
DB, IF
Unconjugated
400 µl/$393
Tuberin / TSC2 Antibody - Western blot of Phospho-Tuberin (T1462) antibody
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (1400-1480 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Tuberin / TSC2 Antibody - Immunohistochemical analysis of TSC2 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
Tuberin / TSC2 Antibody - Immunohistochemical analysis of TSC2 (pT1462) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (pThr1462) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
Tuberin / TSC2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using Tuberin/TSC2 (Ab-939) antibody.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (p939) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
Tuberin / TSC2 Antibody - Anti-TSC2 / Tuberin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Tuberin / TSC2 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Tuberin/TSC2 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (aa905-954) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
Tuberin / TSC2 Antibody - 1:100 staining rat lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Tuberin / TSC2 Antibody - 1:100 staining human liver tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (pThr1462) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Tuberin / TSC2 Antibody - Western blot of Tuberin antibody
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (880-960 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Tuberin / TSC2 Antibody - IHC of Tuberin/TSC2 (F933) pAb in paraffin-embedded human lung carcinoma tissue.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (Phe933) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Tuberin / TSC2 Antibody - Tuberin antibody IHC-paraffin: Rat Brain Tissue.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (aa1611-1807) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Tuberin / TSC2 Antibody - Immunofluorescent analysis of Hela cells using TSC2 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
Tuberin / TSC2 Antibody - Western blot analysis of extracts of various cell lines, using TSC2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Tuberin / TSC2 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using Tuberin/TSC2 (Phospho-Ser939) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer939) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer1254) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$489
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal (pSer939) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Horse, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$489
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$489
Select
Tuberin / TSC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$489
Viewing 1-25 of 233 product results


Filtered By:
Products: Antibodies


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).