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Infectious Disease
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Fax: +1 (206) 577-4565
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TGFB1 / TGF Beta 1
transforming growth factor, beta 1
TGFB1 / TGF Beta 1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
| Gene Name: | transforming growth factor, beta 1 |
| Family/Subfamily: | TGF beta , not assigned-TGF beta |
| Synonyms: | TGFB1, CED, DPD1, Diaphyseal dysplasia 1, LAP, Latency-associated peptide, TGF Beta, TGFbeta, TGF-beta 1 protein, TGF-beta-1, TGFB |
| Target Sequences: | NM_000660 NP_000651.3 P01137 |
Publications (13)
1
Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-ß1/Smad pathway in diabetic mice. Huang C, Shen S, Ma Q, Chen J, Gill A, Pollock CA, Chen XM. Diabetes. 2013 62:2923-34. (WB; Zebrafish)
[Full Text Article]
[PubMed:23656889]
[PMC:PMC3717839]
2
Bone regeneration in minipigs by intrafibrillarly-mineralized collagen loaded with autologous periodontal ligament stem cells. Zhang C, Yan B, Cui Z, Cui S, Zhang T, Wang X, Liu D, Yang R, Jiang N, Zhou Y, Liu Y. Scientific reports. 2017 September;7:10519. (Pig)
[Full Text Article]
[PubMed:28874877]
[PMC:PMC5585269]
Related Antibodies: LS-C10852.
3
Integrin a?ß5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats. Perrucci GL, Barbagallo VA, Corlianò M, Tosi D, Santoro R, Nigro P, Poggio P, Bulfamante G, Lombardi F, Pompilio G. Journal of translational medicine. 2018 December;16:352. [Full Text Article]
[PubMed:30541573]
[PMC:PMC6292173]
☰ Filters
Products
Proteins
(51)
Type
Recombinant
(51)
Target
TGFB1 / TGF Beta 1
(51)
Application
Bind
(1)
ELISA
(1)
Func
(1)
SDS-PAGE
(3)
Format
Animal-free
(1)
Publications
No
(51)
Tag
6His, N-terminus
(5)
6His-SUMO, N-terminus
(3)
GST
(1)
GST, N-terminus
(2)
His
(4)
His, N-Terminal
(5)
His,C-terminus
(4)
His,N-terminus
(1)
His-AVI, N-terminus
(1)
His-GST
(4)
His-S
(1)
Human IgG4 Fc
(1)
Myc-DDK (Flag)
(1)
Species
Bovine
(2)
Chicken
(1)
Dog
(1)
Guinea pig
(1)
Horse
(1)
Human
(27)
Mouse
(7)
Pig
(1)
Rabbit
(1)
Rainbow trout
(1)
Rat
(5)
Sheep
(1)
Xenopus laevis
(2)
Source
CHO Cells
(5)
E. coli
(21)
HEK 293 Cells
(8)
Human
(3)
Human Cells
(3)
Mammalian Cells
(5)
Wheat Germ Extract
(3)
Yeast
(2)
Purification
Purified
(18)
Low Endotoxin Level
Low endotoxin level
(26)
Biologically Active
Biologically active
(11)
Animal-free
Animal-free
(1)
CHO Cells
Human IgG4 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
67 kDa
100 µg/$519
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
E. coli
His, N-Terminal
14.3 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
E. coli
His, N-Terminal
14.3 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
E. coli
6His, N-terminus
15.1 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His
16.9 kD
100 µg/$598; 1 mg/$1,679; 20 µg/$405
HEK 293 Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
25.0 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$511; 500 µg/$1,348; 20 µg/$311
E. coli
His-GST
45.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
HEK 293 Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.8 kDa
5 µg/$303; 100 µg/$1,159
E. coli
6His-SUMO, N-terminus
29 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
None
Biologically active
Less than 0.1 ng/µg of protein.
25.0 kDa
10 µg/$411
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse Latent TGFB1 comprises 372 amino acids and has a predicted molecular mass of 42.7 kDa. The apparent molecular mass of the protein is approximately 54, 41 and 15 kDa in SDS-PAGE under reducing conditions.
100 µg/$519; 1 mg/$2,675
Mammalian Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.8 kDa
10 µg/$317; 50 µg/$524
E. coli
His-GST
45.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His
14.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
None
1 mg/$1,756; 100 µg/$611; 20 µg/$447
E. coli
6His, N-terminus
34.0 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
E. coli
His, N-Terminal
15kDa
10 µg/$362; 50 µg/$902; 200 µg/$1,553; 100 µg/$1,325; 1 mg/$2,881; 500 µg/$2,369; 5 mg/$6,301; 2 mg/$3,361
Wheat Germ Extract
GST, N-terminus
2 µg/$439
Wheat Germ Extract
GST, N-terminus
2 µg/$439
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human latent TGFß1 consists of 370 amino acids and has a calculated molecular mass of 42.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh TGFß1 is approximately 16, 38 and 55 kDa corresponding to mature TGFß1, LAP protein and inacitve latent TGFß1 respectively due to glycosylation. In non-reduced SDS-PAGE, it migrates as an approximately 110 kDa protein consisting of a TGFß1 homodimer non-covalently linked to a LAP homodimer.
50 µg/$441; 500 µg/$1,991
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant Latency-associated peptide(LAP)of human TGFB1 consists of 260 amino acids and predicts a molecular mass of 29.9 kDa.
50 µg/$441; 500 µg/$1,991
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of 51
product results
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