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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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MCAM / CD146

melanoma cell adhesion molecule

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene Name: melanoma cell adhesion molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: MCAM, CD146, CD146 antigen, Gicerin, Melanoma adhesion molecule, MUC18, p1h12
Target Sequences: NM_006500 NP_006491.2 P43121

Publications (1)

1
Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. The Journal of investigative dermatology. 2015 135:1849-1862. (WB; Human) [Full Text Article] [PubMed:25756799] [PMC:PMC4466041] Related Antibodies: LS-B4050.

Viewing 1-25 of 174 items
MCAM / CD146 Antibody - Anti-MCAM / CD146 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer
Mouse Monoclonal [clone 6C3E6] (IgG1) to Human MCAM / CD146
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $425.00
MCAM / CD146 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Mouse Monoclonal [clone 6C3F1] (IgG1) to Human MCAM / CD146
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg   1mg/ml   $425.00
MCAM / CD146 Antibody - Anti-MCAM / CD146 antibody IHC of human vessels in human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Select
Mouse Monoclonal [clone P1H12] (IgG1) to Human MCAM / CD146
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µg   0.5mg/ml   $425.00
MCAM / CD146 Antibody - Anti-MCAM / CD146 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Rabbit Polyclonal to Human MCAM / CD146
Human
IHC, IHC-P, WB
Unconjugated
50µg   0.25mg/ml   $425.00
MCAM / CD146 Antibody - Anti-MCAM / CD146 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human MCAM / CD146
Rabbit, Bovine, Pig, Horse, Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $485.00
MCAM / CD146 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human MCAM / CD146
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $425.00
Select
Mouse Monoclonal (IgG2a) to Rat MCAM / CD146
Rat
ELISA, Flo, WB
Unconjugated
100µg   $650.00
MCAM / CD146 Antibody - Formalin-fixed and paraffin-embedded human skin reacted with MCAM Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human MCAM / CD146
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
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Rabbit Polyclonal (IgG) to Human MCAM / CD146
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
MCAM / CD146 Antibody - Immunohistochemistry Dilution at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
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Rabbit Monoclonal (IgG) to Human MCAM / CD146
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50µl   $315.00; 100µl   $425.00
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Rabbit Polyclonal to Human MCAM / CD146
Human
ELISA, Flo, ICC, IF, IHC, IHC-P
Unconjugated
50µl   $245.00; 100µl   $305.00; 1ml   $1,335.00
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Mouse Monoclonal (IgG1) to Human MCAM / CD146
Rabbit, Mouse, Dog, Human
ELISA, Flo, ICC, IHC, IP
Biotin Conjugated
100µg   $680.00
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Mouse Monoclonal (IgG1) to Human MCAM / CD146
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated, Azide-free
1mg   $875.00
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Mouse Monoclonal [clone P1H12] (IgG1) to Human MCAM / CD146
Rabbit, Mouse, Canine, Human
Flo, ICC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1mg   1mg/ml   $255.00
Select
Mouse Monoclonal [clone P1H12] (IgG1) to Human MCAM / CD146
Rabbit, Mouse, Canine, Human
Flo, ICC, IHC-Fr, IHC-P, IP, WB
PE Conjugated
100tst   $315.00
MCAM / CD146 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MCAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).
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Mouse Monoclonal [clone OTI5C4] (IgG1) to Human MCAM / CD146
Human
IHC, IHC-P, WB
Unconjugated
100µl   $345.00
Select
Rabbit Monoclonal [clone 044] (IgG) to Human MCAM / CD146
Human
Flo, ICC, IF
FITC Conjugated
25tst   0.1mg/ml   $225.00; 100tst   0.1mg/ml   $305.00
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Mouse Monoclonal (IgG1) to Human MCAM / CD146
Rabbit, Mouse, Dog, Human
Flo, IHC, IHC-Fr
FITC Conjugated
100µg   1mg/ml   $590.00
MCAM / CD146 Antibody - MCAM / CD146 antibody. IHC(P): Human Intestinal Cancer Tissue.
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Rabbit Polyclonal to Human MCAM / CD146
Human
IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $355.00
MCAM / CD146 Antibody - Flow cytometric analysis of Mouse MCAM(CD146) expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse MCAM(CD146), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Select
Rabbit Monoclonal [clone 241] (IgG) to Mouse MCAM / CD146
Mouse
ELISA, Flo
Unconjugated, Preservative Free
50µl   $245.00; 100µl   $305.00
Select
Rabbit Monoclonal (IgG) to Human MCAM / CD146
Human
IHC, WB
Unconjugated
50µl   $445.00
Select
Sheep Polyclonal (IgG) to Mouse MCAM / CD146
Mouse
ELISA, WB
Unconjugated
100µg   $770.00
MCAM / CD146 Antibody - Western blot of recombinant MCAM / CD146.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Mouse MCAM / CD146
Mouse
WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $295.00; 500µl   0.5mg/ml   $435.00; 1ml   0.5mg/ml   $515.00
MCAM / CD146 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with CD146 antibody (MUC18/1130).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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Mouse Monoclonal [clone MUC18/1130] (IgG1,k) to Human MCAM / CD146
Human
Flo, IF, IHC, IHC-P
Unconjugated
20µg   0.2mg/ml   $295.00; 100µg   0.2mg/ml   $465.00
MCAM / CD146 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with CD146 antibody (MUC18/1130).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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Mouse Monoclonal [clone MUC18/1130] (IgG1,k) to Human MCAM / CD146
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free
100µg   1mg/ml   $465.00

Viewing 1-25 of 174 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).