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B2M / Beta 2 Microglobulin

beta-2-microglobulin

B2M / Beta 2 Microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Gene Name: beta-2-microglobulin
Synonyms: B2M, Beta 2 Microglobulin, Beta-2-microglobulin, Beta-2-microglobin
Target Sequences: NM_004048 NP_004039.1 P61769

Publications (9)

1
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Meissner TB, Li A, Biswas A, Lee KH, Liu YJ, Bayir E, Iliopoulos D, van den Elsen PJ, Kobayashi KS. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:13794-9. [PubMed:20639463] [PMC:PMC2922274] Related Antibodies: LS-B2200.
2
Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules. Rizvi SM, Del Cid N, Lybarger L, Raghavan M. Journal of immunology (Baltimore, Md. : 1950). 2011 186:2309-20. [PubMed:21263072] [PMC:PMC3057457] Related Antibodies: LS-B2200.
3
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression. Meissner TB, Liu YJ, Lee KH, Li A, Biswas A, van Eggermond MC, van den Elsen PJ, Kobayashi KS. Journal of immunology (Baltimore, Md. : 1950). 2012 188:4951-8. [PubMed:22490869] [PMC:PMC3345046] Related Antibodies: LS-B2200.
4
Young bone marrow transplantation preserves learning and memory in old mice. Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS. Communications biology. 2019 February;2:73. [Full Text Article] [PubMed:30820468] [PMC:PMC6382867]
5
Platelet-derived ß2M regulates monocyte inflammatory responses. Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante AA, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN. JCI insight. 2019 March;4:pii: 122943. [Full Text Article] [PubMed:30702442] [PMC:PMC6483513]
6
Platelet-derived ß2m regulates age related monocyte/macrophage functions. Hilt ZT, Ture SK, Mohan A, Arne A, Morrell CN. Aging. 2019 December;11:11955-11974. [Full Text Article] [PubMed:31852838] [PMC:PMC6949047]
7
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Jillian F Wise, Sigve Nakken, Chloé B Steen, Daniel Vodák, Gunhild Trøen, Bjarne Johannessen, Ole Christian Lingjærde, Vera Hilden, Yngvild Nuvin Blaker, Baoyan Bai, Lars Birger Aasheim, Annika Pasanen, Susanne Lorenz, Anita Sveen, Ragnhild A Lothe, Ola Myklebost, Sirpa Leppä, Leonardo A Meza-Zepeda, Klaus Beiske, Michael S Lawrence, Eivind Hovig, June Helen Myklebust, Erlend B Smeland, Harald Holte. Blood Advances. 2020 May;4:1859-1866. [Full Text Article] [PubMed:32374878] [PMC:PMC7218413] Related Antibodies: LS-B2200.
8
Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker10<sup> The Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, UK. sm460@le.ac.uk. Marta Poblocka, Akang Leonard Bassey , Victoria M Smith, Marta Falcicchio , Ana Sousa Manso, Mohammad Althubiti , XiaoBo Sheng, Andrew Kyle, Ruth Barber, Mark Frigerio, Salvador Macip. Scientific reports. 2021 Oct;11:20358. [Full Text Article] [PubMed:34645909] [PMC:PMC8514501] Related Antibodies: LS-B2200.
9
ß2<sub>-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Daniel Hofbauer, Dimitrios Mougiakakos, Luca Broggini, Mario Zaiss, Maike Büttner-Herold, Christian Bach, Bernd Spriewald, Frank Neumann, Savita Bisht, Jens Nolting, Robert Zeiser, Shaima'a Hamarsheh, Martin Eberhardt, Julio Vera, Cristina Visentin, Chiara Maria Giulia De Luca, Fabio Moda, Stefan Haskamp, Cindy Flamann, Martin Böttcher, Katrin Bitterer, Simon Völkl, Andreas Mackensen, Stefano Ricagno, Heiko Bruns. Immunity. 2021 August;54:1772-1787e9. [Full Text Article] [PubMed:34289378] Related Antibodies: LS-B2200.
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B2M / Beta 2 Microglobulin Antibody - Anti-B2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Cancer
B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal (2M2) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µg/$460
B2M / Beta 2 Microglobulin Antibody - Anti-B2M antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer
B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal (B2M-01) Antibody
Human
ELISA, Flo, ICC, IHC, IHC-P, IP, RIA, WB
Unconjugated
0.1 mg/$460
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B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal (HRP) (B2M-01) Antibody
Human
ELISA, Flo, ICC, IHC-P, IP, RIA, WB
HRP Conjugated
0.1 mg/$351
B2M / Beta 2 Microglobulin Antibody - Anti-B2M / Beta 2 Microglobulin antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal (Concentrated) (B2M-01) Antibody
Human
ELISA, Flo, IHC, IHC-P, IP, RIA, WB
Unconjugated, Concentrated
50 µg/$440
B2M / Beta 2 Microglobulin Antibody - Anti-B2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Cancer
B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal (B2M-02) Antibody
Porcine, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
B2M / Beta 2 Microglobulin Antibody - Anti-B2M antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$515
B2M / Beta 2 Microglobulin Antibody - Anti-B2M / Beta 2 Microglobulin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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B2M / Beta 2 Microglobulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
B2M / Beta 2 Microglobulin Antibody - Anti-B2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal (2213) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
0.05 ml/$495
B2M / Beta 2 Microglobulin Antibody - Anti-B2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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B2M / Beta 2 Microglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
0.25 mg/$515
B2M / Beta 2 Microglobulin Antibody - Immunohistochemistry of Rabbit anti-Beta-2-Microglobulin Antibody. Tissue: normal human skin. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: Left panel: isotype control, Right panel: ß2 microglobulin antibody at 1 ug/ml for 20 min at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: ß2 microglobulin is cell membrane (and to lesser amount cytoplasmatic compartment). Staining: Beta-2-Microglobulin as brown with diaminobenzidine and with a hematoxylin purple counterstain.
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B2M / Beta 2 Microglobulin Rabbit anti-Human Polyclonal (Lyophilized) (HRP) Antibody
Human
ELISA, IF, IHC, WB
HRP Conjugated, Lyophilized
500 µg/$606
B2M / Beta 2 Microglobulin Antibody - B2M / Beta-2-Microglobulin antibody Western blot of Fetal Thymus lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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B2M / Beta 2 Microglobulin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
B2M / Beta 2 Microglobulin Antibody - Anti-B2M / Beta 2 Microglobulin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal (3F9-2C2) Antibody
Human
ELISA, IF, IHC, IHC-P, RNAi, WB
Unconjugated
50 µg/$460
B2M / Beta 2 Microglobulin Protein - Recombinant Beta-2-Microglobulin By SDS-PAGE
Select
E. coli
His, N-Terminal
12.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
B2M / Beta 2 Microglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$344
B2M / Beta 2 Microglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$745
B2M / Beta 2 Microglobulin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
B2M / Beta 2 Microglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IHC-P, IP, WB
Unconjugated
0.1 mg/$460
B2M / Beta 2 Microglobulin ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
12.5 - 800 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
B2M / Beta 2 Microglobulin Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:200.
Select
Cancer
B2M / Beta 2 Microglobulin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
B2M / Beta 2 Microglobulin Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
HEK 293 Cells
6His, N-terminus
14 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432; 250 µg/$726; 500 µg/$1,270
B2M / Beta 2 Microglobulin Antibody - Anti-B2M antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
B2M / Beta 2 Microglobulin Mouse anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
200 µg/$460
B2M / Beta 2 Microglobulin Antibody - Western blot of recombinant B2M / Beta 2 Microglobulin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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B2M / Beta 2 Microglobulin Rabbit anti-Mouse Polyclonal (aa22-119) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
B2M / Beta 2 Microglobulin Antibody - Western blot of recombinant B2M / Beta 2 Microglobulin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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B2M / Beta 2 Microglobulin Rabbit anti-Mouse Polyclonal (aa22-119) (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248
B2M / Beta 2 Microglobulin Antibody - SDS-PAGE Analysis of Purified, BSA-Free Beta-2 Microglobulin Antibody (clone BBM.1). Confirmation of Integrity and Purity of the Antibody.
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B2M / Beta 2 Microglobulin Mouse anti-Human Monoclonal (Azide-free, BSA-free) (BBM.1) Antibody
Human
Flo, IF, IHC, IHC-Fr
Unconjugated, Azide-free, BSA-free
100 µg/$574
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.5 kDa
100 µg/$532; 1 mg/$2,785
B2M / Beta 2 Microglobulin ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Viewing 1-25 of 311 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).