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SPP1 / Osteopontin

secreted phosphoprotein 1

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Gene Name: secreted phosphoprotein 1
Synonyms: SPP1, BSPI, BNSP, Bone sialoprotein 1, ETA-1, Nephropontin, OPN, Secreted phosphoprotein 1, SPP-1, SPP1/CALPHA1 fusion, Urinary stone protein, Uropontin, Osteopontin, Bone sialoprotein I
Target Sequences: NM_000582 NP_000573.1 P10451

Publications (8)

1
Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. Kon S, Yokosaki Y, Maeda M, Segawa T, Horikoshi Y, Tsukagoshi H, Rashid MM, Morimoto J, Inobe M, Shijubo N, Chambers AF, Uede T. Journal of cellular biochemistry. 2002 84:420-32. [PubMed:11787071]
2
Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells. Robertson BW, Chellaiah MA. Experimental cell research. 2010 316:11-Jan. [PubMed:19850036] [PMC:PMC2787770] Related Antibodies: LS-B425.
3
Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Rui YF, Lui PP, Rolf CG, Wong YM, Lee YW, Chan KM. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2012 20:1409-17. (IHC; Human) [PubMed:21946950]
4
Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXR-induced -catenin degradation. Xu L, Song C, Ni M, Meng F, Xie H, Li G. The international journal of biochemistry & cell biology. 2012 44:612-9. [PubMed:22230368]
5
Effects of Cryopreservation on Canine Multipotent Stromal Cells from Subcutaneous and Infrapatellar Adipose Tissue. Duan W, Lopez MJ. Stem cell reviews. 2016 12:257-68. (ICC, Flo; Canine) [Full Text Article] [PubMed:26537238] [PMC:PMC4841859] Related Antibodies: LS-B425.
6
Early Elevation of Systemic Plasma Clusterin after Reperfused Acute Myocardial Infarction in a Preclinical Porcine Model of Ischemic Heart Disease. Denise Traxler, Andreas Spannbauer, Patrick Einzinger, Julia Mester-Tonczar, Dominika Lukovic, Johannes Winkler, Katrin Zlabinger, Alfred Gugerell, LJubica Mandic, Mariann Gyöngyösi, Noemi Pavo. International journal of molecular sciences. 2020 June;21: [Full Text Article] [PubMed:32605184] [PMC:PMC7369988]
7
Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression. Chia-Hung Hsu, Hon-Ping Ma, Jiann Ruey Ong, Ming-Shou Hsieh, Vijesh Kumar Yadav, Chi-Tai Yeh, Tsu-Yi Chao, Wei-Hwa Lee, Wen-Chien Huang, Kuang-Tai Kuo, Iat-Hang Fong, Chih-Cheng Lin, Chih-Ming Su. Disease Markers. 2022 July;2022:8446629. [Full Text Article] [PubMed:35903297] [PMC:PMC9325341]
8
Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization. Anja Schlecht, Peipei Zhang, Julian Wolf, Adrian Thien, Dennis-Dominik Rosmus, Stefaniya Boneva, Günther Schlunck, Clemens Lange, Peter Wieghofer. Frontiers in cell and developmental biology. 2021 February;8:618598. [Full Text Article] [PubMed:33585455] [PMC:PMC7876283] Related Antibodies: LS-C169155.
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SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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Cancer
SPP1 / Osteopontin Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Pig, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$460
SPP1 / Osteopontin Antibody - Anti-Hemopexin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SPP1 / Osteopontin Mouse anti-Human Monoclonal (C-Terminus) (1B20) Antibody
Rabbit, Rat, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$460
SPP1 / Osteopontin Antibody - Anti-SPP1 / Osteopontin antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer
SPP1 / Osteopontin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SPP1 / Osteopontin Goat anti-Human Polyclonal (aa288-299) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
SPP1 / Osteopontin Antibody - SPP1 / Osteopontin antibody ARP36677_T100-NP_000573-SPP1 Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SPP1 / Osteopontin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
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SPP1 / Osteopontin Goat anti-Mouse Polyclonal (PE) Antibody
Mouse
Flo
PE Conjugated
100 Tests/$811
SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SPP1 / Osteopontin Mouse anti-Human Monoclonal (X1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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SPP1 / Osteopontin Rabbit anti-Human Polyclonal (aa14-40) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
SPP1 / Osteopontin Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma with SPP1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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SPP1 / Osteopontin Rabbit anti-Human Polyclonal (aa273-301) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SPP1 / Osteopontin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$582
SPP1 / Osteopontin ELISA Kit
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Sandwich
96-Well Microplate
Pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
SPP1 / Osteopontin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
6.86 - 5000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$871
SPP1 / Osteopontin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$889
SPP1 / Osteopontin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
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HEK 293 Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
60.0-65.0 kDa
10 µg/$268; 50 µg/$349
SPP1 / Osteopontin Antibody - Anti-SPP1 / Osteopontin antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Cancer
SPP1 / Osteopontin Rabbit anti-Human Polyclonal (aa14-40) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$460
SPP1 / Osteopontin Antibody - IHC of paraffin-embedded prostate cancer tissues using SPP1 mouse monoclonal antibody with DAB staining.
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SPP1 / Osteopontin Mouse anti-Human Monoclonal (7C5H12) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$459
SPP1 / Osteopontin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
39 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$610
SPP1 / Osteopontin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
50 - 18000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
SPP1 / Osteopontin ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SPP1 / Osteopontin Antibody - Anti-SPP1 / Osteopontin antibody IHC staining of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
SPP1 / Osteopontin Rabbit anti-Human Polyclonal (aa261-310) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
SPP1 / Osteopontin Antibody
Select
SPP1 / Osteopontin Mouse anti-Human Monoclonal (aa17-314) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$445
SPP1 / Osteopontin Antibody - Anti-Osteopontin antibody IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SPP1 / Osteopontin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SPP1 / Osteopontin Antibody - Western blot of Osteopontin antibody at 2 ug/ml with mouse kidney tissue Secondary Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 32 KDa. Observed band size: 32 KDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SPP1 / Osteopontin Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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SPP1 / Osteopontin Rabbit anti-Human Polyclonal (aa17-302) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Viewing 1-25 of 222 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).