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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Rho Kinase / ROCK1

Rho-associated, coiled-coil containing protein kinase 1

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.

Gene Name: Rho-associated, coiled-coil containing protein kinase 1
Family/Subfamily: Protein Kinase , ROCK
Synonyms: ROCK1, p160 Rho-associated kinase, p160ROCK, p160 ROCK-1, p160-ROCK, p160RhoK, Rho-associated kinase, RockI, Rok, Rok alpha, Rho-alpha kinase, p160 rho-kinase, Rho kinase, ROCK-I, Rokalpha
Target Sequences: NM_005406 NP_005397.1 Q13464

Publications (1)

1
Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid-induced apoptosis. Zucchini-Pascal N, de Sousa G, Pizzol J, Rahmani R. Liver international : official journal of the International Association for the Study of the Liver. 2010 30:284-97. (WB) [PubMed:19737350]

Filtered by: None
Target
Rho Kinase / ROCK1 (44)
Reactivity
Human (42)
Mouse (34)
Rat (17)
Bat (1)
Bovine (2)
Dog (1)
Horse (1)
Monkey (3)
Pig (1)
Rabbit (2)
Application
IHC (22)
IHC-P (7)
WB (41)
Flo (1)
ELISA (9)
ICC (6)
IF (6)
IP (5)
Peptide-ELISA (1)
Host
rabbit (38)
mouse (6)
Isotype
IgG (22)
IgG1 (3)
IgG1,k (1)
Clonality
monoclonal mc (8)
polyclonal pc (36)
Clone
154C1465 (1)
1H4 (2)
2E2 (1)
AB01/1F3 (1)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (2)
PE Conjugated (2)
Unconjugated (29)
Epitope
aa1094-1323 (10)
Internal (2)
240-320 aa, Internal (1)
Asn311 (1)
C-Terminus (1)
aa107-371 (1)
aa1114-1126 (1)
aa262-311 (1)
aa400-450 (1)
Publications
No (44)
Showing 1-25 of 44 results

Rho Kinase / ROCK1 Antibody IHC-plus™ LS-B7100
Rabbit Polyclonal (IgG) to Human Rho Kinase / ROCK1
Mouse, Rat, Human
ELISA ICC IF IHC IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-ROCK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunocytochemistry of ROCK1 in 293 cells with ROCK1 antibody at 10 ug/ml.

Rho Kinase / ROCK1 Antibody (clone 2E2) LS-C198099
Mouse Monoclonal [clone 2E2] (IgG1,k) to Human Rho Kinase / ROCK1
Human
ELISA IF WB
Unconjugated
100µg  $355.00
Immunofluorescence of monoclonal antibody to ROCK1 on HeLa cell. [antibody concentration 10 ug/ml]
ROCK1 monoclonal antibody (M01), clone 2E2 Western Blot analysis of ROCK1 expression in HeLa NE.

Rho Kinase / ROCK1 Antibody LS-C497794
Rabbit Monoclonal to Human Rho Kinase / ROCK1
Mouse, Rat, Human
Flo IF IHC IP WB
Unconjugated
50µl  $295.00; 100µl  $385.00; 200µl  $560.00
Immunohistochemistry of paraffin-embedded mouse thyroid using ROCK1 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human thyroid using ROCK1 antibodyat dilution of 1:100 (40x lens).

Rho Kinase / ROCK1 Antibody IHC-plus™ LS-B7892
Rabbit Polyclonal (IgG) to Human Rho Kinase / ROCK1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-Rho Kinase / ROCK1 antibody IHC of human adrenal, adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-Rho Kinase / ROCK1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

Rho Kinase / ROCK1 Antibody LS-C75509
Rabbit Monoclonal (IgG) to Human Rho Kinase / ROCK1
Mouse, Rat, Human
IP WB
Unconjugated
20µl  $395.00; 100µl  $605.00

Rho Kinase / ROCK1 Antibody (aa1114-1126, clone 154C1465) LS-C511
Mouse Monoclonal [clone 154C1465] (IgG) to Human Rho Kinase / ROCK1
Mouse, Dog, Bovine, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
100µg 200µl 0.5mg/ml  $335.00
Detection of cleaved ROCK-1 in apoptotic Jurkat cell lysates (10 µg/lane). Lane 1. Jurkat cells were treated with camptothecin. Lane 2. Jurkat cells were treated with anti-Fas antibody (10 ng/ml for 2 hrs). antibody was used at a concentration of 1 ug/ml.

Rho Kinase / ROCK1 Antibody (aa107-371) LS-C186291
Rabbit Polyclonal to Human Rho Kinase / ROCK1
Human
ICC IHC IHC-P WB
Unconjugated
100µl 0.68mg/ml  $355.00
IHC of paraffin-embedded DLD1 xenograft using ROCK1 antibody at 1:500 dilution.
Immunofluorescence of methanol-fixed HeLa using ROCK1 antibody at 1:200 dilution.

Rho Kinase / ROCK1 Antibody (Internal) LS-C385933
Rabbit Polyclonal (IgG) to Human Rho Kinase / ROCK1
Mouse, Rat, Human, Monkey
ELISA ICC IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Rock-1 antibody

Rho Kinase / ROCK1 Antibody LS-C393377
Rabbit Polyclonal to Human Rho Kinase / ROCK1
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
100µl  $305.00

Rho Kinase / ROCK1 Antibody LS-C393380
Rabbit Polyclonal to Human Rho Kinase / ROCK1
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
100µl  $305.00

Rho Kinase / ROCK1 Antibody LS-C408278
Rabbit Polyclonal (IgG) to Human Rho Kinase / ROCK1
Mouse, Rat, Human
IHC IP WB
Unconjugated
50µl  $255.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded rat heart using ROCK1 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using ROCK1 antibodyat dilution of 1:100 (40x lens).

Rho Kinase / ROCK1 Antibody (aa1094-1323) LS-C374823
Rabbit Polyclonal to Mouse Rho Kinase / ROCK1
Mouse, Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $545.00; 10ml 0.5mg/ml  $2,160.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rho Kinase / ROCK1 Antibody (aa1094-1323, HRP) LS-C713130
Rabbit Polyclonal to Mouse Rho Kinase / ROCK1
Mouse, Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $295.00; 200µl  $345.00; 1ml  $695.00; 10ml  $2,805.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rho Kinase / ROCK1 Antibody (aa1094-1323, Biotin) LS-C688388
Rabbit Polyclonal to Mouse Rho Kinase / ROCK1
Mouse, Human
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $275.00; 200µl  $315.00; 1ml  $590.00; 10ml  $2,370.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rho Kinase / ROCK1 Antibody (aa1094-1323, FITC) LS-C695334
Rabbit Polyclonal to Mouse Rho Kinase / ROCK1
Mouse, Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $335.00; 1ml  $650.00; 10ml  $2,580.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rho Kinase / ROCK1 Antibody (aa1094-1323, Cy3) LS-C704109
Rabbit Polyclonal to Mouse Rho Kinase / ROCK1
Mouse, Human
IHC WB
Cy3 Conjugated
20µl  $245.00; 100µl  $365.00; 200µl  $445.00; 1ml  $1,080.00; 10ml  $4,320.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rho Kinase / ROCK1 Antibody (aa1094-1323, APC) LS-C718619
Rabbit Polyclonal to Mouse Rho Kinase / ROCK1
Mouse, Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $315.00; 200µl  $375.00; 1ml  $815.00; 10ml  $3,900.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rho Kinase / ROCK1 Antibody (aa1094-1323, PE) LS-C727193
Rabbit Polyclonal to Mouse Rho Kinase / ROCK1
Mouse, Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $335.00; 1ml  $650.00; 10ml  $2,580.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rho Kinase / ROCK1 Antibody (aa1094-1323, APC, Cy7) LS-C736113
Rabbit Polyclonal to Mouse Rho Kinase / ROCK1
Mouse, Human
IHC WB
APC, Cy7 Conjugated
20µl  $285.00; 100µl  $465.00; 200µl  $650.00; 1ml  $1,620.00; 10ml  $6,480.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

Rho Kinase / ROCK1 Antibody (Internal) LS-C352778
Rabbit Polyclonal to Human Rho Kinase / ROCK1
Rabbit, Mouse, Bovine, Rat, Pig, Human, Monkey
ICC IF WB
Unconjugated
100µl 1mg/ml  $245.00
Immunofluorescent analysis of ROCK1 staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Western blot analysis of ROCK1 expression in HeLa (A); NIH3T3 (B); C6 (C); COS7 (D) whole cell lysates.

Rho Kinase / ROCK1 Antibody LS-C660577
Rabbit Polyclonal (IgG) to Human Rho Kinase / ROCK1
Human
ELISA IHC WB
Unconjugated
100µg  $435.00

Rho Kinase / ROCK1 Antibody LS-C660578
Rabbit Polyclonal (IgG) to Human Rho Kinase / ROCK1
Human
ELISA IHC WB
Unconjugated
100µg  $435.00

Rho Kinase / ROCK1 Antibody (clone 1H4) LS-C169453
Mouse Monoclonal [clone 1H4] (IgG1) to Human Rho Kinase / ROCK1
Human
ELISA WB
Unconjugated
100µg 1mg/ml  $365.00
Western blot using ROCK1 monoclonal antibody against human ROCK1 (AA: 403-610) recombinant protein. (Expected MW is 158 kDa)
Western blot using ROCK1 monoclonal antibody against HEK293 (1) and ROCK1 (AA: 403-610)-hIgGFc transfected HEK293 (2) cell lysate.

Rho Kinase / ROCK1 Antibody (aa262-311) LS-C291734
Rabbit Polyclonal (IgG) to Human Rho Kinase / ROCK1
Mouse, Rat, Human
IHC Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of Rock-1 antibody in paraffin-embedded human brain tissue.
Western blot analysis of lysate from COS7 cell, using Rock-1 antibodys.

Rho Kinase / ROCK1 Antibody (Asn311) LS-C177597
Rabbit Polyclonal to Human Rho Kinase / ROCK1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of Rock-1 (N311) pAb in paraffin-embedded human brain tissue.
Western blot of Rock-1 (N311) pAb in extracts from COS7 cells.
Showing 1-25 of 44 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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