Human Rho Kinase / ROCK1
ROCK1 | p160 Rho-associated kinase | p160ROCK | p160 ROCK-1 | p160-ROCK | p160RhoK | Rho-associated kinase | RockI | Rok | Rok alpha | Rho-alpha kinase | p160 rho-kinase | Rho kinase | ROCK-I | Rokalpha
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse
(tested or 100% immunogen sequence identity)
Rabbit (at least 90% immunogen sequence identity)
This antibody was generated by immunizing mice with a synthetic peptide sequence corresponding to residues 1114-1126 GNLPESRIEGWLS of human ROCK-1. Immunogen peptide sequence is adjacent to the caspase-3 cleavage site of ROCK-1. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Bovine, Dog, Bat, Horse, Opossum, Platypus (100%); Rabbit (92%); Chicken (85%).
This mAb recognizes the cleaved C-terminus of ROCK-1. It does not recognize the full-length protein. Since ROCK-1 is cleaved by caspase-3 during apoptosis, this may be used for detection of apoptosis.