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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
Protein Family And Group
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Catalog Number Size Price
LS-C511-100 100 µg (0.5 mg/ml) $335 
Rho Kinase / ROCK1 Antibody - Detection of cleaved ROCK-1 in apoptotic Jurkat cell lysates (10 µg/lane). Lane 1. Jurkat cells were treated with camptothecin. Lane 2. Jurkat cells were treated with anti-Fas antibody (10 ng/ml for 2 hrs). antibody was used at a concentration of 1 ug/ml.

Monoclonal Rho Kinase / ROCK1 Antibody (clone 154C1465, aa1114‑1126, WB) LS‑C511

Monoclonal Rho Kinase / ROCK1 Antibody (clone 154C1465, aa1114‑1126, WB) LS‑C511

Note: This antibody replaces LS-C93367
Antibody:
Mouse Monoclonal to Human Rho Kinase / ROCK1
Application:
WB
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse
Format:
Unconjugated, Unmodified
Price
Catalog Number
$335 
LS-C511-100
100 µg
0.5 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Mouse Monoclonal to Human Rho Kinase / ROCK1
Application:
WB
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse
Format:
Unconjugated, Unmodified

Specifications

Description
ROCK1 antibody LS-C511 is an unconjugated mouse monoclonal antibody to ROCK1 (Rho Kinase ) from human, mouse, rat and other species. Validated for WB.
Target
Human Rho Kinase / ROCK1
Synonyms
ROCK1 | p160 Rho-associated kinase | p160ROCK | p160 ROCK-1 | p160-ROCK | p160RhoK | Rho-associated kinase | RockI | Rok | Rok alpha | Rho-alpha kinase | p160 rho-kinase | Rho kinase | ROCK-I | Rokalpha
Host
Mouse
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse (tested or 100% immunogen sequence identity)
Predicted
Rabbit (at least 90% immunogen sequence identity)
Clonality
IgG Monoclonal
Clone
154C1465
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot (1 - 2 µg/ml)
Failed Applications
  • IHC - Paraffin
Immunogen
This antibody was generated by immunizing mice with a synthetic peptide sequence corresponding to residues 1114-1126 GNLPESRIEGWLS of human ROCK-1. Immunogen peptide sequence is adjacent to the caspase-3 cleavage site of ROCK-1. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Bovine, Dog, Bat, Horse, Opossum, Platypus (100%); Rabbit (92%); Chicken (85%).
Epitope
aa1114-1126
Specificity
This mAb recognizes the cleaved C-terminus of ROCK-1. It does not recognize the full-length protein. Since ROCK-1 is cleaved by caspase-3 during apoptosis, this may be used for detection of apoptosis.
Presentation
PBS, 0.05% Sodium Azide, 0.2% Gelatin
Storage
Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About Rho Kinase / ROCK1
Q13464 NM_005406 NP_005397.1

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Requested From: United States
Date Requested: 2/22/2020