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NALP3 / NLRP3

NLR family, pyrin domain containing 3

NALP3 / NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Gene Name: NLR family, pyrin domain containing 3
Synonyms: NLRP3, AGTAVPRL, AII, C1orf7, Caterpiller protein 1.1, Cryopyrin, FCAS, FCU, PYPAF1, NALP3, CIAS1, CLR1.1, MWS
Target Sequences: NM_004895 NP_004886.3 Q96P20

Publications (18)

1
Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS. Walsh JG, Reinke SN, Mamik MK, McKenzie BA, Maingat F, Branton WG, Broadhurst DI, Power C. Retrovirology. 2014 11:35. (IHC; Human) [Full Text Article] [PubMed:24886384] [PMC:PMC4038111] Related Antibodies: LS-B4321.
2
High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB. World journal of diabetes. 2017 8:56-65. (WB; Rat) [Full Text Article] [PubMed:28265343] [PMC:PMC5320749] Related Antibodies: LS-B4321.
3
LRRC8/VRAC anion channels enhance ß-cell glucose sensing and insulin secretion. Stuhlmann T, Planells-Cases R, Jentsch TJ. Nature communications. 2018 May;9:1974. (Human) [Full Text Article] [PubMed:29773801] [PMC:PMC5958052]
4
Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model. Islam N Mohamed, Nader Sheibani, Azza B El-Remessy. International journal of molecular sciences. 2020 June;21: [Full Text Article] [PubMed:32492941] [PMC:PMC7312035] Related Antibodies: LS-B4321.
5
Fructose stimulated de novo lipogenesis is promoted by inflammation. Jelena Todoric, Giuseppe Di Caro, Saskia Reibe, Darren C Henstridge, Courtney R Green, Alison Vrbanac, Fatih Ceteci, Claire Conche, Reginald McNulty, Shabnam Shalapour, Koji Taniguchi, Peter J Meikle, Jeramie D Watrous, Rafael Moranchel, Mahan Najhawan, Mohit Jain, Xiao Liu, Tatiana Kisseleva, Maria T Diaz-Meco, Jorge Moscat, Rob Knight, Florian R Greten, Lester F Lau, Christian M Metallo, Mark A Febbraio, Michael Karin. Nature metabolism. 2020 October;2:1034-1045. [Full Text Article] [PubMed:32839596] [PMC:PMC8018782] Related Antibodies: LS-C334192.
6
Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis. Zahra Tavakoli Dargani, Dinender K Singla. American journal of physiology. Endocrinology and metabolism. 2019 August;317:H460-H471. [Full Text Article] [PubMed:31172809] [PMC:PMC6732475] Related Antibodies: LS-B4321.
7
Blockade of ß-adrenergic signaling suppresses inflammasome and alleviates cardiac fibrosis. Shipeng Dang, Zhen-Ye Zhang, Ku-Lin Li, Jie Zheng, Ling-Ling Qian, Xiao-Yu Liu, Ying Wu, Chang-Ying Zhang, Xiao-Xi Zhao, Zhi-Ming Yu, Ru-Xing Wang, Tingbo Jiang. Annals of translational medicine. 2020 February;8:127. [Full Text Article] [PubMed:32175420] [PMC:PMC7048978] Related Antibodies: LS-C334192.
8
Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia. Sally L Elshaer, Islam N Mohamed, Maha Coucha, Sara Altantawi, Wael Eldahshan, Megan L Bartasi, Ahmed Y Shanab, Renee Lorys, Azza B El-Remessy. Antioxidants (Basel, Switzerland). 2017 Jun;6:47. [Full Text Article] [PubMed:28661427] [PMC:PMC5618075] Related Antibodies: LS-B4321.
9
Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. P M Abdul-Muneer, Saleena Alikunju, Vikas Mishra, Heather Schuetz, Adam M Szlachetka, Ellen L Burnham, James Haorah. Brain, behavior, and immunity. 2017 May;62:291-305. [Full Text Article] [PubMed:28232172] [PMC:PMC6378699] Related Antibodies: LS-C148764.
10
Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Maha Coucha, Ahmed Y Shanab, Mohamed Sayed, Almira Vazdarjanova, Azza B El-Remessy. International journal of molecular sciences. 2019 Aug;20:3969. [Full Text Article] [PubMed:31443163] [PMC:PMC6721134] Related Antibodies: LS-B4321.
11
Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Ibolya E András, Marta Garcia-Contreras, Christopher Yanick, Paola Perez, Brice Sewell, Leonardo Durand, Michal Toborek. Molecular brain. 2019 Feb;13:21. [Full Text Article] [PubMed:32066471] [PMC:PMC7027073] Related Antibodies: LS-B4321.
12
Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Ran Cheng , Sandrine Billet , Chuanxia Liu, Subhash Haldar, Diptiman Choudhury, Manisha Tripathi, Monirath Hav, Akil Merchant, Tao Hu, Haiyun Huang, Hongmei Zhou, Neil A Bhowmick. Oncogene. 2020 Feb;39:1543-1556. [Full Text Article] [PubMed:31685946] [PMC:PMC7018659] Related Antibodies: LS-C162911.
13
NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. Francis M Hughes Jr, Nathan A Hirshman, Brian M Inouye, Huixia Jin, Eloise W Stanton, Chloe E Yun, Leah G Davis, Jonathan C Routh, J Todd Purves. Diabetes. 2019 Feb;68:430-440. [Full Text Article] [PubMed:30425063] [PMC:PMC6341307] Related Antibodies: LS-C334192.
14
Clinical Significance of High-Mobility Group Box 1 Protein (HMGB1) and Nod-Like Receptor Protein 3 (NLRP3) in Patients with Ulcerative Colitis. YanMin Chen, Dong Wu, LingJia Sun. Medical science monitor : international medical journal of experimental and clinical research. 2020 Jan;26:e919530. [Full Text Article] [PubMed:31901930] [PMC:PMC6977607]
15
Plasma-borne indicators of inflammasome activity in Parkinson's disease patients. Faith L Anderson, Katharine M von Herrmann, Angeline S Andrew, Yuliya I Kuras, Alison L Young, Clemens R Scherzer, William F Hickey, Stephen L Lee, Matthew C Havrda. NPJ Parkinson's disease. 2021 Jan;7:2. [Full Text Article] [PubMed:33398042] [PMC:PMC7782812]
16
Implication of the NLRP3 Inflammasome in Bovine Age-Related Sarcopenia. Davide De Biase, Giuseppe Piegari, Francesco Prisco, Ilaria Cimmino, Ilaria d'Aquino, Valeria Baldassarre, Francesco Oriente, Serenella Papparella, Orlando Paciello. International journal of molecular sciences. 2021 Mar;22:3609. [Full Text Article] [PubMed:33808510] [PMC:PMC8036417] Related Antibodies: LS-B8262.
17
Inflammasome-mediated neurodegeneration following heart disease. Kuan Cheng #, Jingjing Wang #, Qingxing Chen, Gang Zhao, Yang Pang, Ye Xu, Junbo Ge, Wenqing Zhu. Annals of Translational Medicine. 2021 Oct;;9:1560. [Full Text Article] [PubMed:34790766] [PMC:PMC8576725]
18
Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains. Davide De Biase, Giuseppe Piegari, Francesco Prisco, Ilaria Cimmino, Claudio Pirozzi, Giuseppina Mattace Raso, Francesco Oriente, Edoardo Grieco, Serenella Papparella, Orlando Paciello. Journal of cellular physiology. 2020 June;235:5394-5403. [Full Text Article] [PubMed:31903559] Related Antibodies: LS-B8262.
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NALP3 / NLRP3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
NALP3 / NLRP3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa158-207) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NALP3 / NLRP3 Antibody - Anti-NALP3 / NLRP3 antibody IHC of human colon, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa158-207) (Biotin) Antibody
Dog, Human, Monkey, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NALP3 / NLRP3 Antibody - Anti-NLRP3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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NALP3 / NLRP3 Mouse anti-Human Monoclonal (Nalpy3-b ) Antibody
Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$495
NALP3 / NLRP3 Antibody - NLRP3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lymph tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa65-91) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human, Monkey
WB
Unconjugated
0.2 ml/$386
NALP3 / NLRP3 Antibody - Anti-NLRP3 antibody IHC of human peripheral blood leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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NALP3 / NLRP3 Goat anti-Human Polyclonal (aa82-93) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
NALP3 / NLRP3 Antibody - Western blot analysis of extracts of K-562 cell line, using NLRP3 antibody.
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NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
NALP3 / NLRP3 Antibody - Western blot of NALP3 / NLRP3 antibody.
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NALP3 / NLRP3 Rabbit anti-Mouse Polyclonal (aa671-1033) Antibody
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
NALP3 / NLRP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
NALP3 / NLRP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
NALP3 / NLRP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
NALP3 / NLRP3 Protein - Recombinant NLR Family, Pyrin Domain Containing Protein 3 By SDS-PAGE
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E. coli
His, N-Terminal
43.9 kDa
10 µg/$281; 50 µg/$442; 200 µg/$882; 1 mg/$1,989; 5 mg/$3,081; 2 mg/$2,176
NALP3 / NLRP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NALP3 / NLRP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
NALP3 / NLRP3 Protein - 12.5% SDS-PAGE of human NLRP3 stained with Coomassie Blue
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Wheat Germ Extract
GST
144.6 kDa
2 µg/$439
NALP3 / NLRP3 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
68.6 - 50000 pg/ml
Chemiluminescent
Cell Lysates, Tissue Homogenates
1 Plate/$851
NALP3 / NLRP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
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E. coli
316 AA
6His, N-terminus + 6His, C-terminus
Less than 0.1 EU/µg protein (determined by LAL method).
34.87 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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NALP3 / NLRP3 Mouse anti-Human Monoclonal (aa4-223) (1D4B) Antibody
Human
ICC
Unconjugated
100 µg/$896
NALP3 / NLRP3 Antibody - NALP3 / NLRP3 antibody. IHC(P): Human Tonsil Tissue.
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NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa12-31) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
NALP3 / NLRP3 Antibody - Immunohistochemistry of Cryopyrin antibody
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NALP3 / NLRP3 Rabbit anti-Human Polyclonal (501-550 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa65-91) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
NALP3 / NLRP3 Antibody - Western blot analysis of NLRP3 expression in SHSY5Y (A); THP1 (B) whole cell lysates.
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NALP3 / NLRP3 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
NALP3 / NLRP3 Antibody - NALP3 / NLRP3 antibody (5µg/ml) staining of paraffin embedded Human Peripheral Blood Leukocytes. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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NALP3 / NLRP3 Goat anti-Human Polyclonal (C-Terminus) Antibody
Human
Flo, IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µg/$503
Viewing 1-25 of 72 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).