Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Catalog Number Size Price
LS-B4321-0.05 0.05 mg (1 mg/ml) $545 
NALP3 / NLRP3 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
NALP3 / NLRP3 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
NALP3 / NLRP3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
NALP3 / NLRP3 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
NALP3 / NLRP3 Antibody - Western blot of NLRP3 in K562 cell lysate with NLRP3 antibody at 1 ug/ml (A) in the absence and (B) in the presence of blocking peptide.
NALP3 / NLRP3 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
NALP3 / NLRP3 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
NALP3 / NLRP3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
NALP3 / NLRP3 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
NALP3 / NLRP3 Antibody - Western blot of NLRP3 in K562 cell lysate with NLRP3 antibody at 1 ug/ml (A) in the absence and (B) in the presence of blocking peptide.
1 of 5
2 of 5
3 of 5
4 of 5
5 of 5

PathPlus™ Polyclonal Rabbit anti‑Human NALP3 / NLRP3 Antibody (IHC, IF, WB) LS‑B4321

PathPlus™ Polyclonal Rabbit anti‑Human NALP3 / NLRP3 Antibody (IHC, IF, WB) LS‑B4321

Note: This antibody replaces LS-C108609
Antibody:
NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Price
Catalog Number
$545
LS-B4321-0.05
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified

Specifications

Target
Human NALP3 / NLRP3
Synonyms
NLRP3 | AGTAVPRL | AII | C1orf7 | Caterpiller protein 1.1 | Cryopyrin | FCAS | FCU | PYPAF1 | NALP3 | CIAS1 | CLR1.1 | MWS
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Peptide Column Affinity Chromatography
Modifications
Unmodified
Immunogen
A 16 AA synthetic peptide near the N-Terminus of human NALP3. The immunogen is located within aa 120-170 of NALP3.
Applications
  • IHC
  • IHC - Paraffin (2.5 - 5 µg/ml)
  • ICC (2 µg/ml)
  • Immunofluorescence (20 µg/ml)
  • Western blot (1 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
NALP3 antibody can be used for detection of NALP3 by Western blot at 1 ug/mL. Antibody can also be used for Immunocytochemistry starting at 2 ug/mL. For immunofluorescence start at 20 ug/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Western Blot: Predicted: 101, 114 kDa Observed: 110 kDa
Presentation
PBS containing 0.02% Sodium Azide
Storage
Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NALP3 / NLRP3
Q96P20 NM_004895 NP_004886.3

Validation

NALP3 / NLRP3 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

NALP3 / NLRP3 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

NALP3 / NLRP3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

NALP3 / NLRP3 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ NALP3 / NLRP3 Antibody for IHC, ICC, IF/Immunofluorescence, WB/Western, ELISA LS-B4321 has an LSBio Rating of
Publications (4.6)
Laboratory Validation Score (5)

Publications (7)

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS. Walsh JG, Reinke SN, Mamik MK, McKenzie BA, Maingat F, Branton WG, Broadhurst DI, Power C. Retrovirology. 2014 11:35. (IHC; Human)

High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB. World journal of diabetes. 2017 8:56-65. (WB; Rat)

Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model. Islam N Mohamed, Nader Sheibani, Azza B El-Remessy. International journal of molecular sciences. 2020 June;21:

Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis. Zahra Tavakoli Dargani, Dinender K Singla. American journal of physiology. Endocrinology and metabolism. 2019 August;317:H460-H471.

Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia. Sally L Elshaer, Islam N Mohamed, Maha Coucha, Sara Altantawi, Wael Eldahshan, Megan L Bartasi, Ahmed Y Shanab, Renee Lorys, Azza B El-Remessy. Antioxidants (Basel, Switzerland). 2017 Jun;6:47.

Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Maha Coucha, Ahmed Y Shanab, Mohamed Sayed, Almira Vazdarjanova, Azza B El-Remessy. International journal of molecular sciences. 2019 Aug;20:3969.

Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Ibolya E András, Marta Garcia-Contreras, Christopher Yanick, Paola Perez, Brice Sewell, Leonardo Durand, Michal Toborek. Molecular brain. 2019 Feb;13:21.

more

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 10/22/2021