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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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MCL1 / MCL 1

myeloid cell leukemia sequence 1 (BCL2-related)

Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Gene Name: myeloid cell leukemia sequence 1 (BCL2-related)
Synonyms: MCL1, BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, MCL1S, MCL1L, Myeloid cell leukemia ES, MCL 1, MCL1-ES, TM, EAT, Mcl-1
Target Sequences: NM_021960 NP_068779.1 Q07820

Publications (5)

1
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Molecular and cellular biology. 2007 27:4328-39. [PubMed:17371841] [PMC:PMC1900055]
2
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJ, Cohen GM. Blood. 2009 113:4403-13. (IP) [PubMed:19008458]
3
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J. Journal of immunology (Baltimore, Md. : 1950). 2010 185:6670-8. [PubMed:21048108]
4
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. The Journal of biological chemistry. 2011 286:5921-33. [PubMed:21159778] [PMC:PMC3037705]
5
A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. Baumgartner CK, Yagita H, Malherbe LP. Journal of immunology (Baltimore, Md. : 1950). 2012 189:2309-17. [PubMed:22844120] [PMC:PMC3424363]
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Viewing 1-25 of 145 items
MCL1 / MCL 1 Antibody - Anti-MCL1 / MCL 1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 2E11] (IgG2a) to Human MCL1 / MCL 1
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50µl   0.9mg/ml   $425.00
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
Flo, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl   0.35mg/ml   $740.00
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl   0.5mg/ml   $740.00
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
Mouse Monoclonal [clone 8C6D4B1] (IgG1) to Human MCL1 / MCL 1
Human
ELISA, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
MCL1 / MCL 1 Antibody - MCL1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Rabbit Polyclonal to Human MCL1 / MCL 1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
MCL1 / MCL 1 Antibody - IHC of paraffin-embedded Kidney tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI10D10] (IgG2a) to Human MCL1 / MCL 1
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.95mg/ml   $345.00
MCL1 / MCL 1 Antibody - IHC of paraffin-embedded breast tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI10F6] (IgG1) to Human MCL1 / MCL 1
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
MCL1 / MCL 1 Antibody - IHC of paraffin-embedded breast tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI10F6] (IgG1) to Human MCL1 / MCL 1
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:25.
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human
IHC, IHC-P
Unconjugated
250µl   $425.00
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Rabbit Polyclonal to Human MCL1 / MCL 1
Rabbit, Dog, Guinea pig, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
MCL1 / MCL 1 Antibody - Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human
ELISA, ICC, WB
Unconjugated
0.1mg   1mg/ml   $365.00
Select
Mouse Monoclonal [clone MCL.C9] (IgG) to Human MCL1 / MCL 1
Human
ELISA, WB
Unconjugated
100µg   $385.00
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 8C6D4B1] (IgG1) to Human MCL1 / MCL 1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
MCL1 / MCL 1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone 10C5] (IgG1) to Human MCL1 / MCL 1
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   0.75mg/ml   $425.00
MCL1 / MCL 1 Antibody - Immunohistochemistry of paraffin-embedded human pancreas using MCL1 antibodyat dilution of 1:100 (40x lens).
Select
Rabbit Monoclonal to Human MCL1 / MCL 1
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
50µl   $295.00; 100µl   $385.00; 200µl   $560.00
Select
Mouse Monoclonal (IgG1) to Human MCL1 / MCL 1
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µg   $605.00
MCL1 / MCL 1 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MCL1 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
MCL1 / MCL 1 Antibody - Western blot of Phospho-Mcl-1 (S159) antibody
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA, IF, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Mouse Monoclonal (IgG1,k) to Human MCL1 / MCL 1
Human
IP, WB
Unconjugated
250µl   $425.00; 500µl   $635.00
Select
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human
IP, WB
Unconjugated
100µl   0.2mg/ml   $395.00
MCL1 / MCL 1 Antibody - IHC of paraffin-embedded colon tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI9C9] (IgG2b) to Human MCL1 / MCL 1
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   0.72mg/ml   $345.00
MCL1 / MCL 1 Antibody - IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI9D7] (IgG2a) to Human MCL1 / MCL 1
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   0.81mg/ml   $345.00

Viewing 1-25 of 145 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).