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LRP6

low density lipoprotein receptor-related protein 6

Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) is a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. LRP6 functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade LRP6 plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. LRP6 undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Gene Name: low density lipoprotein receptor-related protein 6
Synonyms: LRP6, ADCAD2, LRP-6
Target Sequences: NM_002336 NP_002327.2 O75581

Publications (2)

1
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Liu CC, Prior J, Piwnica-Worms D, Bu G. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:5136-41. [PubMed:20194742] [PMC:PMC2841938] Related Antibodies: LS-C100405.
2
Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation. Kannan S, Nicola Z, Overall RW, Ichwan M, Ramírez-Rodríguez G, N Grzyb A, Patone G, Saar K, Hübner N, Kempermann G. Stem cells (Dayton, Ohio). 2016 March;34:674-84. (Human) [Full Text Article] [PubMed:26840599]

☰ Filters
Antibodies (31)
ELISA Kits (14)
Proteins (4)
Competitive EIA (1)
Custom (1)
Over-Expression Lysate (2)
Primary (31)
Recombinant (2)
Sandwich (11)
Sandwich CLIA (1)
LRP6 (49)
Human (36)
Mouse (10)
Rat (7)
Chicken (1)
Dog (1)
Hamster (1)
Horse (1)
Monkey (2)
Pig (1)
Porcine (1)
Rabbit (2)
Sheep (1)
IHC (14)
IHC-P (5)
WB (26)
Flo (1)
ELISA (13)
IF (1)
IP (1)
Peptide-ELISA (1)
rabbit (29)
mouse (1)
goat (1)
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IgG1 (1)
monoclonal mc (2)
polyclonal pc (29)
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Cy7 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (18)
aa1531-1560 (8)
aa981-1213 (8)
pSer1490 (2)
aa1547-1560 (1)
aa20-150 (1)
No (48)
Yes (1)
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293T Cells (1)
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HEK 293 Cells (2)
LRP6 Antibody - Anti-LRP6 antibody IHC of human hepatocytes and bile duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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LRP6 Goat anti-Human Polyclonal (aa1547-1560) Antibody
Rabbit, Dog, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$460
LRP6 Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with LRP6 Antibody (C-term T1546), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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LRP6 Rabbit anti-Human Polyclonal (aa1531-1560) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$381
LRP6 Protein - Recombinant Low Density Lipoprotein Receptor Related Protein 6 By SDS-PAGE
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E. coli
His, N-Terminal
30.4 kDa
10 µg/$271; 50 µg/$420; 100 µg/$670; 200 µg/$836; 1 mg/$1,873; 500 µg/$1,389; 5 mg/$4,051
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LRP6 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
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LRP6 Rabbit anti-Human Monoclonal Antibody
Mouse, Human
IP, WB
Unconjugated
100 µl/$580
LRP6 Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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LRP6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
LRP6 Antibody - Immunohistochemistry of paraffin-embedded rat heart using LRP6 antibody at dilution of 1:100 (40x lens).
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LRP6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
LRP6 Antibody - Western blot analysis using LRP6 mAb against HEK293 (1) and LRP6 (AA: extra 1198-1370)-hIgGFc transfected HEK293 (2) cell lysate.
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LRP6 Mouse anti-Human Monoclonal (1A3F5) Antibody
Human
ELISA, Flo, WB
Unconjugated
0.1 mg/$426
LRP6 Protein - Purified recombinant protein LRP6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
178.4 kDa
20 µg/$1,024
LRP6 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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LRP6 Rabbit anti-Human Polyclonal (aa20-150) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$282; 100 µl/$348
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LRP6 Rabbit anti-Human Polyclonal (aa1531-1560) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$653
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LRP6 Rabbit anti-Human Polyclonal (aa1531-1560) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$828
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LRP6 Rabbit anti-Human Polyclonal (aa1531-1560) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$828
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LRP6 Rabbit anti-Human Polyclonal (aa1531-1560) (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
200 µl/$828
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LRP6 Rabbit anti-Human Polyclonal (aa1531-1560) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$828
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LRP6 Rabbit anti-Human Polyclonal (aa1531-1560) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$828
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LRP6 Rabbit anti-Human Polyclonal (aa1531-1560) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$828
LRP6 Antibody
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LRP6 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$276; 100 µl/$311
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LRP6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$242; 60 µl/$284; 120 µl/$343; 200 µl/$451
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LRP6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$347
LRP6 Antibody - Western blot analysis of Phospho-LRP6 (Ser1490) using HeLa whole cells lysates
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LRP6 Rabbit anti-Human Polyclonal (pSer1490) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$369; 200 µl/$411
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LRP6 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
WB
Unconjugated
60 µl/$278; 120 µl/$338; 200 µl/$440
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LRP6 Rabbit anti-Human Polyclonal (pSer1490) Antibody
Human
WB
Unconjugated
100 µg/$716
LRP6 Antibody - Western blot of recombinant LRP6.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LRP6 Rabbit anti-Human Polyclonal (aa981-1213) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$341; 500 µl/$481; 1 ml/$551
LRP6 Antibody - Western blot analysis of extracts of various cell lines, using LRP6 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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LRP6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
Viewing 1-25 of 49 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).