Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Gene Name: | histone cell cycle regulator |
Synonyms: | HIRA, DGCR1, HIR, TUPLE1, Protein HIRA |
Target Sequences: | NM_003325 NP_003316.3 P54198 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.