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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HIRA Antibody (aa431‑461) LS‑C99986
HIRA antibody LS-C99986 is an unconjugated rabbit polyclonal antibody to human HIRA. Validated for WB.
Catalog
Size
Price
LS-C99986-400
400 µl
$305

Popular HIRA Products

Western blot Image
Species: Human
Applications: Western blot
Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using HIRA Antibody. The picture on the right is blocked with the synthesized peptide.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Peptide Enzyme-Linked Immunosorbent Assay
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-TUPLE1 mAb.
Species: Human
Applications: ICC, Immunofluorescence, Western blot, Dot Blot
Antibody
Species: Human, Mouse
Applications: IHC, Immunofluorescence, ELISA
Immunohistochemistry of paraffin-embedded human lung cancer tissue.
Species: Human, Mouse
Applications: IHC, Western blot

Product Description

HIRA antibody LS-C99986 is an unconjugated rabbit polyclonal antibody to human HIRA. Validated for WB.

Specifications

Target
Human HIRA
Synonyms
HIRA, DGCR1, HIR, TUPLE1, Protein HIRA
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Mouse, Chicken, Xenopus (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Ammonium sulfate precipitation
Modifications
Unmodified
Applications
  • Western blot (1:1000)
Blocking Peptide
LS-E8172 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C99986. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa431-461
Specificity
This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-461 amino acids from the Central region of human HIRA.
Presentation
PBS, 0.09% Sodium Azide
Storage
Maintain refrigerated at 2°C to 8°C for up to 6 months. For long term storage store at -20°C.
Restrictions
For research use only.
About HIRA
HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. P54198 NM_003325 NP_003316.3


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Images

Western blot

HIRA Antibody western blot of HeLa cell line lysates (35 ug/lane). The HIRA antibody detected the HIRA protein (arrow).
HIRA Antibody western blot of HeLa cell line lysates (35 ug/lane). The HIRA antibody detected the HIRA protein (arrow).

Western blot

HIRA Antibody western blot of HeLa cell line lysates (35 ug/lane). The HIRA antibody detected the HIRA protein (arrow).
HIRA Antibody western blot of HeLa cell line lysates (35 ug/lane). The HIRA antibody detected the HIRA protein (arrow).

Western blot

HIRA Antibody western blot of HeLa cell line lysates (35 ug/lane). The HIRA antibody detected the HIRA protein (arrow).
HIRA Antibody western blot of HeLa cell line lysates (35 ug/lane). The HIRA antibody detected the HIRA protein (arrow).

Western blot

HIRA Antibody western blot of HeLa cell line lysates (35 ug/lane). The HIRA antibody detected the HIRA protein (arrow).
HIRA Antibody western blot of HeLa cell line lysates (35 ug/lane). The HIRA antibody detected the HIRA protein (arrow).

Requested From: United States
Date Requested: 11/14/2018

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