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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GSK3A / GSK3 Alpha

glycogen synthase kinase 3 alpha

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Gene Name: glycogen synthase kinase 3 alpha
Family/Subfamily: Protein Kinase , GSK-3
Synonyms: GSK3A, GSK-3 alpha, GSK3 alpha
Target Sequences: NM_019884 NP_063937.2 P49840

Publications (1)

1
Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents. Shakoori A, Mai W, Miyashita K, Yasumoto K, Takahashi Y, Ooi A, Kawakami K, Minamoto T. Cancer science. 2007 98:1388-93. (IHC) [PubMed:17640304]

Viewing 1-25 of 142 items
GSK3A / GSK3 Alpha Antibody - Anti-GSK3A / GSK3 Alpha antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Select
Rabbit Polyclonal to Human GSK3A / GSK3 Alpha
Human
IHC, IHC-P, WB
Unconjugated
200µl   $425.00
GSK3A / GSK3 Alpha Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
Select
Rabbit Monoclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
100µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Zebrafish, Drosophila, Rat, Mouse, Bovine, Human, Monkey
IF, IHC, WB
Unconjugated
50µg   $435.00
Select
Rabbit Polyclonal (IgG) to Mouse GSK3A / GSK3 Alpha
Mouse
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Mouse GSK3A / GSK3 Alpha
Mouse
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
IHC, WB
Unconjugated
100µg   200µl   $475.00
Select
Mouse Monoclonal (IgG1) to Drosophila GSK3A / GSK3 Alpha
Insect, Drosophila
ICC, WB
Unconjugated
100µg   $695.00
GSK3A / GSK3 Alpha Antibody - WB: HEK293 cell lysate was probed with anti-GSK3/ (1:5,000 dilution). Arrows indicate GSK3 (~51kDa) and GSK3 (~46kDa).
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Rabbit Monoclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Human
IP, WB
Unconjugated
100µg   $415.00
GSK3A / GSK3 Alpha Antibody - Immunohistochemical analysis of GSK3 alpha (pS21) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $265.00
GSK3A / GSK3 Alpha Antibody - Immunohistochemical analysis of GSK3 alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
Select
Mouse Monoclonal [clone 13A190] (IgG1) to Human GSK3A / GSK3 Alpha
Human
Flo
FITC Conjugated
100tst   $590.00
Select
Rabbit Polyclonal to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
WB
Unconjugated
10blot   $635.00
GSK3A / GSK3 Alpha Antibody - IF using GSK3 alpha Antibody (9D5G1)
Select
Mouse Monoclonal [clone 9D5G1] (IgG1) to Human GSK3A / GSK3 Alpha
Human
ICC, IF, IHC, WB
Unconjugated
100µl   $425.00
Select
Mouse Monoclonal (IgG1,k) to Drosophila GSK3A / GSK3 Alpha
Drosophila
WB
Unconjugated
200µg   $680.00
GSK3A / GSK3 Alpha Antibody
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
GSK3A / GSK3 Alpha Antibody
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
GSK3A / GSK3 Alpha Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
IF, IHC, WB
Unconjugated
50µl   $265.00; 100µl   $375.00; 200µl   $495.00
GSK3A / GSK3 Alpha Antibody - Western blot of Phospho-GSK3alpha (S21) antibody
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
GSK3A / GSK3 Alpha Antibody
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
GSK3A / GSK3 Alpha Antibody - Western blot of GSK3alpha antibody
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
GSK3A / GSK3 Alpha Antibody
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Zebrafish, Drosophila, Rat, Mouse, Bovine, Human, Monkey
IF, IHC, WB
Unconjugated
50µg   $435.00
GSK3A / GSK3 Alpha Antibody - Immunofluorescent analysis of Hela cells using GSK3A Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Rat, Human
ELISA, IF, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
GSK3A / GSK3 Alpha Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using GSK3 alpha (Phospho-Ser21) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human GSK3A / GSK3 Alpha
Mouse, Rat, Human
IHC, IHC-P, IP, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00

Viewing 1-25 of 142 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).