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COL1A1 / Collagen I Alpha 1

collagen, type I, alpha 1

COL1A1 / Collagen I Alpha 1 is the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Gene Name: collagen, type I, alpha 1
Family/Subfamily: Collagen , not assigned-Collagen
Synonyms: COL1A1, Alpha-1 type I collagen, Collagen alpha 1 chain type I, Collagen alpha-1(I) chain, Collagen, type I, alpha 1, Collagen I, Pro-alpha-1 collagen type 1, OI4
Target Sequences: NM_000088 NP_000079.2 P02452

Publications (9)

1
The Role of Periostin in Capsule Formation on Silicone Implants. Bae HS, Son HY, Lee JP, Chang H, Park JU. BioMed research international. 2018 April;2018:3167037. (Mouse, Human) [Full Text Article] [PubMed:29854742] [PMC:PMC5944282] Related Antibodies: LS-C343921.
2
Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence. Petra Sántha, Daniela Lenggenhager, Anette Finstadsveen, Linda Dorg, Kristin Tøndel, Manoj Amrutkar, Ivar P Gladhaug, Caroline Verbeke. Cancers. 2021 February;13: [Full Text Article] [PubMed:33672734] [PMC:PMC7924365] Related Antibodies: LS-B5932.
3
Mechanical process prior to cryopreservation of lipoaspirates maintains extracellular matrix integrity and cell viability: evaluation of the retention and regenerative potential of cryopreserved fat-derived product after fat grafting. Jingwei Feng, Wansheng Hu, Mimi Lalrimawii Fanai, Shengqian Zhu, Jing Wang, Junrong Cai, Feng Lu. Stem cell research & therapy. 2019 September;10:283. [Full Text Article] [PubMed:31547884] [PMC:PMC6755707] Related Antibodies: LS-B5932.
4
A selective small-molecule inhibitor of c-Met suppresses keloid fibroblast growth in vitro and in a mouse model. Min-Ha Choi , Jinhyun Kim , Jeong Hyun Ha, Ji-Ung Park. Scientific reports. 2021 March;11:5468. [Full Text Article] [PubMed:33750878] [PMC:PMC7943593] Related Antibodies: LS-C343921.
5
BRCA1 mutation influences progesterone response in human benign mammary organoids. Batzaya Davaadelger, Mi-Ran Choi, Hari Singhal, Susan E Clare, Seema A Khan, J Julie Kim. Breast cancer research : BCR. 2019 Nov;21:124. [Full Text Article] [PubMed:31771627] [PMC:PMC6878650] Related Antibodies: LS-C343921.
6
BRCA1 mutation influences progesterone response in human benign mammary organoids. Zihui Zhang, Shuang Li, Jie Deng, Shaorong Yang, Ziwu Xiang, Hongyan Guo, Hongli Xi, Ming Sang, Wei Zhang. International journal of molecular medicine. 2019 May;45:1351-1360. [Full Text Article] [PubMed:32323728] [PMC:PMC7138280] Related Antibodies: LS-C343921.
7
In Situ Characterization of Human Lymphoid Tissue Immune Cells by Multispectral Confocal Imaging and Quantitative Image Analysis; Implications for HIV Reservoir Characterization. Eirini Moysi, Perla M Del Rio Estrada, Fernanda Torres-Ruiz, Gustavo Reyes-Terán , Richard A Koup, Constantinos Petrovas. Frontiers in immunology. 2021 Jun;12:683396. [Full Text Article] [PubMed:34177929] [PMC:PMC8221112] Related Antibodies: LS-B5932.
8
TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex. Nicole Merritt , Keith Garcia , Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S Chimenti, Anne-Claude Gingras, Kieran F Harvey, Munir R Tanas. eLife. 2021 April;10:e62857. [Full Text Article] [PubMed:33913810] [PMC:PMC8143797] Related Antibodies: LS-B5932.
9
TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis. Kasparas Petkevicius, Henrik Palmgren, Matthew S Glover, Andrea Ahnmark, Anne-Christine Andréasson, Katja Madeyski-Bengtson, Hiroki Kawana, Erik L Allman, Delaney Kaper, Martin Uhrbom, Liselotte Andersson, Leif Aasehaug, Johan Forsström, Simonetta Wallin, Ingela Ahlstedt, Renata Leke, Daniel Karlsson, Hernán González-King, Lars Löfgren, Ralf Nilsson, Giovanni Pellegrini, Nozomu Kono, Junken Aoki, Sonja Hess, Grzegorz Sienski, Marc Pilon, Mohammad Bohlooly-Y, Marcello Maresca, Xiao-Rong Peng. Nature communications. 2022 October;13:6020. [Full Text Article] [PubMed:36241646] [PMC:PMC9568529] Related Antibodies: LS-C343921.
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COL1A1 / Collagen I Alpha 1 (9)
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COL1A1 / Collagen I Alpha 1 Protein - Recombinant Collagen Type I Alpha 1 By SDS-PAGE
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E. coli
His, N-Terminal
28.0 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
COL1A1 / Collagen I Alpha 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
139.01 kDa
20 µg/$150
COL1A1 / Collagen I Alpha 1 Protein - Recombinant  Collagen Type I Alpha 1 By SDS-PAGE
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E. coli
His, N-Terminal
26.4 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
COL1A1 / Collagen I Alpha 1 Protein - Recombinant  Collagen Type I Alpha 1 By SDS-PAGE
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E. coli
His
20.9 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
COL1A1 / Collagen I Alpha 1 Protein
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Yeast
His
25.4 kD
1 mg/$1,683; 100 µg/$499; 20 µg/$364
COL1A1 / Collagen I Alpha 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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E. coli
245 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
27.06 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
COL1A1 / Collagen I Alpha 1 Protein
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HEK 293 Cells
His, N-Terminal
40.8 kDa
50 µg/$677
COL1A1 / Collagen I Alpha 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
139.01 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).