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Unfortunately, the antibody (ID:323305) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CLU / Clusterin

clusterin

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Gene Name: clusterin
Synonyms: CLU, APO-J, Apolipoprotein J, CLU1, Clusterin, Complement lysis inhibitor, CLI, AAG4, Aging-associated protein 4, Ku70-binding protein 1, KUB1, SGP2, APOJ, SGP-2, Sulfated glycoprotein 2, CLU2, Complement cytolysis inhibitor, NA1/NA2, SP-40
Target Sequences: NM_001831 NP_001822.3 P10909

Publications (1)

1
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. Yang Y, Keene CD, Peskind ER, Galasko DR, Hu SC, Cudaback E, Wilson AM, Li G, Yu CE, Montine KS, Zhang J, Baird GS, Hyman BT, Montine TJ. Journal of neuropathology and experimental neurology. 2015 74:672-87. (WB; Human) [Full Text Article] [PubMed:26083568] [PMC:PMC4471879] Related Antibodies: LS-C44980.

Filtered By: None
Target
clu-clusterin (198)
Reactivity
Human (112)
Mouse (30)
Rat (27)
Bovine (10)
Cow (8)
Dog (10)
Goat (8)
Horse (4)
Monkey (1)
Pig (23)
Rabbit (12)
Sheep (10)
Application
IHC (84)
IHC-Fr (3)
IHC-P (24)
WB (186)
Flo (20)
ELISA (57)
ICC (21)
IF (7)
IP (14)
Peptide-ELISA (4)
Host
rabbit (118)
mouse (66)
goat (8)
guinea pig (3)
rat (1)
sheep (2)
Isotype
IgG (137)
IgG1 (16)
IgG1,k (11)
IgG2a (1)
IgG2b (1)
Clonality
monoclonal mc (66)
polyclonal pc (132)
Clone
1A11 (2)
3R3/2 (1)
41D (1)
CLI-9 (2)
Hs-3 (2)
HS-3 (1)
s-3 (1)
Format
AP Conjugated (5)
APC (11)
APC Conjugated (14)
Azide-free (5)
Biotin Conjugated (25)
Cy3 Conjugated (11)
Cy7 Conjugated (11)
FITC Conjugated (25)
HRP Conjugated (18)
PE Conjugated (17)
Unconjugated (72)
Epitope
aa227-447 (24)
aa228-449 (19)
aa229-446 (15)
aa226-447 (11)
aa20-439 (10)
aa223-439 (10)
aa227-445 (8)
aa71-99 (8)
aa305-354 (4)
aa1-333 (2)
aa75-501 (2)
C-Terminus (1)
Glu436 (1)
N-Terminus (1)
aa 23-224 (1)
aa23-227 (1)
aa23-449 (1)
aa312-325 (1)
aa370-450 (1)
aa435-448 (1)
aa44-58 (1)
aa488-501 (1)
Publications
No (197)
Yes (1)
Showing 1-25 out of 198 results
CLU / Clusterin Antibody (aa488-501) IHC-plus™ LS-B2852
Anti-Clusterin antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2852 concentration 5 ug/ml.
Antibody (0.3 ug/ml) staining of human colon lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat Polyclonal to Human CLU / Clusterin
Human, Monkey
IHC IHC-P Peptide-ELISA WB
Unconjugated
CLU / Clusterin Antibody (aa75-501, Biotin) LS-C128238

Mouse Monoclonal (IgG2b) to Human CLU / Clusterin
Human
ELISA
Biotin Conjugated
CLU / Clusterin Antibody (clone 3R3/2) LS-C44980

Mouse Monoclonal [clone 3R3/2] (IgG1) to Human CLU / Clusterin
Human
ELISA Flo IHC IHC-Fr WB
Unconjugated
CLU / Clusterin Antibody (aa435-448) LS-C87361
Antibody (0.3 ug/ml) staining of Rat Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

Goat Polyclonal to Mouse CLU / Clusterin
Mouse, Rat
Peptide-ELISA WB
Unconjugated
CLU / Clusterin Antibody (clone Hs-3) IHC-plus™ LS-B1869
Anti-Clusterin antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1869 concentration 10 ug/ml.

Mouse Monoclonal [clone Hs-3] (IgG1) to Human CLU / Clusterin
Human
ELISA ICC IHC IHC-P WB
Unconjugated
CLU / Clusterin Antibody IHC-plus™ LS-B2218
Anti-Clusterin antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2218 concentration 5 ug/ml.

Mouse Monoclonal (IgG1,k) to Human CLU / Clusterin
Human
IHC IHC-P WB
Unconjugated
CLU / Clusterin Antibody (clone 1A11) LS-C196933
Detection limit for recombinant GST tagged CLU is approximately 0.1 ng/ml as a capture antibody.

Mouse Monoclonal [clone 1A11] (IgG1,k) to Human CLU / Clusterin
Human
ELISA WB
Unconjugated
CLU / Clusterin Antibody (aa1-333, clone 1A11) IHC-plus™ LS-B2937
Anti-Clusterin antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2937 concentration 10 ug/ml.
Anti-Clusterin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2937 concentration 10 ug/ml.

Mouse Monoclonal [clone 1A11] (IgG1,k) to Human CLU / Clusterin
Human
ELISA IHC IHC-P WB
Unconjugated
CLU / Clusterin Antibody LS-C79451

Mouse Monoclonal (IgG1) to Human CLU / Clusterin
Human
ELISA ICC IF IHC WB
Unconjugated
CLU / Clusterin Antibody (clone CLI-9) LS-C18638

Mouse Monoclonal [clone CLI-9] (IgG1) to Human CLU / Clusterin
Human
ICC IHC IHC-Fr IP WB
Unconjugated
CLU / Clusterin Antibody LS-C20757

Goat Polyclonal (IgG) to Human CLU / Clusterin
Human
ELISA IHC IHC-P IP WB
Unconjugated
CLU / Clusterin Antibody (Glu436) IHC-plus™ LS-B14491
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human CLU / Clusterin
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
CLU / Clusterin Antibody (aa71-99) IHC-plus™ LS-B13182
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Human CLU / Clusterin
Human
ELISA Flo IHC IHC-P WB
Unconjugated
CLU / Clusterin Antibody (clone s-3) LS-C340755

Mouse Monoclonal [clone s-3] (IgG1) to Human CLU / Clusterin
Human
ELISA ICC IF IHC WB
Unconjugated
CLU / Clusterin Antibody LS-C485489

Mouse Monoclonal to Human CLU / Clusterin
Human
ELISA Flo ICC IF WB
Unconjugated
CLU / Clusterin Antibody (aa75-501) LS-C128237

Mouse Monoclonal (IgG1) to Human CLU / Clusterin
Human
ELISA
Unconjugated
CLU / Clusterin Antibody (aa44-58) IHC-plus™ LS-B14366
Human Liver, Portal Triad: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Goat Polyclonal to Human CLU / Clusterin
Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
CLU / Clusterin Antibody LS-C123269

Mouse Monoclonal (IgG1) to Human CLU / Clusterin
Human
ELISA Flo IHC IHC-Fr IHC-P WB
Unconjugated
CLU / Clusterin Antibody (HRP) LS-C545180

Mouse Monoclonal (IgG1) to Human CLU / Clusterin
Human
ELISA Flo IHC WB
HRP Conjugated
CLU / Clusterin Antibody (Biotin) LS-C525053

Mouse Monoclonal (IgG1) to Human CLU / Clusterin
Human
ELISA Flo IHC WB
Biotin Conjugated
CLU / Clusterin Antibody (FITC) LS-C535074

Mouse Monoclonal (IgG1) to Human CLU / Clusterin
Human
ELISA Flo IHC WB
FITC Conjugated
CLU / Clusterin Antibody (aa71-99) LS-C168862
CLU antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Western blot of lysates from A549 cell line and human plasma tissue lysate(from left to right), using CLU Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

Rabbit Polyclonal to Human CLU / Clusterin
Human
Flo IHC IHC-P WB
Unconjugated
CLU / Clusterin Antibody (aa370-450) LS-C382794
Western blot of Clusterin antibody

Rabbit Polyclonal (IgG) to Human CLU / Clusterin
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
CLU / Clusterin Antibody LS-C331486
Immunohistochemistry of paraffin-embedded human lung cancer tissue.
Immunohistochemistry of paraffin-embedded human stomach cancer tissue.

Rabbit Polyclonal (IgG) to Human CLU / Clusterin
Mouse, Human
IF IHC WB
Unconjugated
CLU / Clusterin Antibody (clone CLI-9) LS-C53511

Mouse Monoclonal [clone CLI-9] (IgG1) to Human CLU / Clusterin
Human
ICC IHC IP WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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