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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD135 / FLT3

fms-related tyrosine kinase 3

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Gene Name: fms-related tyrosine kinase 3
Family/Subfamily: Protein Kinase , PDGF Receptor
Synonyms: FLT3, CD135, CD135 antigen, Fetal liver kinase 2, Fetal liver kinase-2, FL cytokine receptor, FLK2, FLT-3, Fms-like tyrosine kinase 3, Stem cell tyrosine kinase 1, STK-1, FLK-2, Fms-related tyrosine kinase 3, STK1
Target Sequences: NM_004119 NP_004110.2 P36888

Filtered by: None
Target
CD135 / FLT3 (126)
Reactivity
Human (112)
Mouse (57)
Rat (11)
Dog (7)
Horse (7)
Monkey (10)
Pig (7)
Rabbit (7)
Application
IHC (40)
IHC-P (28)
WB (78)
Flo (22)
ELISA (51)
ICC (7)
IF (3)
IP (14)
Peptide-ELISA (6)
Host
rabbit (106)
mouse (16)
rat (4)
Isotype
IgG (59)
IgG1 (10)
IgG2a,k (5)
IgG2b (1)
Clonality
monoclonal mc (20)
polyclonal pc (106)
Clone
1A11 (1)
7B7C3 (1)
A2F10 (4)
BV10A4 (5)
BV10A4H2 (2)
OTI7D6 (2)
Format
AP Conjugated (7)
APC (2)
APC Conjugated (10)
Azide-free (6)
Biotin Conjugated (10)
Carrier-free (1)
Cy3 Conjugated (2)
Cy5 Conjugated (1)
Cy7 Conjugated (2)
FITC Conjugated (11)
HRP Conjugated (9)
PE (1)
PE Conjugated (13)
Unconjugated (61)
Epitope
Internal (8)
aa154-181 (8)
aa33-64 (8)
aa334-543 (8)
aa335-544 (8)
N-Terminus (7)
aa951-982 (7)
pTyr591 (3)
540-620 aa (2)
aa169-444 (2)
pTyr969 (2)
451-500 aa, Internal (1)
780-860 aa (1)
910-990 aa (1)
Asp593 (1)
aa474-510 (1)
aa523-784 (1)
aa544-593 (1)
aa548-597 (1)
aa565-614 (1)
aa786-1000 (1)
aa930-991 (1)
pTyr589/591 (1)
pTyr599 (1)
pTyr842 (1)
Publications
No (126)
Showing 1-25 of 126 results

IHC-plus™ CD135 / FLT3 Antibody (Internal) LS-A7148
Rabbit Polyclonal to Human CD135 / FLT3
Human
ELISA, IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-FLT3 / CD135 antibody IHC of human interfollicular zone. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CD135 / FLT3 Antibody (Internal, Biotin) LS-A106843
Rabbit Polyclonal to Human CD135 / FLT3
Human
ELISA, IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-FLT3 / CD135 antibody IHC of human interfollicular zone. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CD135 / FLT3 Antibody (Internal, AP) LS-A106841
Rabbit Polyclonal to Human CD135 / FLT3
Human
ELISA, IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-FLT3 / CD135 antibody IHC of human interfollicular zone. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CD135 / FLT3 Antibody (Internal, APC) LS-A106842
Rabbit Polyclonal to Human CD135 / FLT3
Human
ELISA, IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-FLT3 / CD135 antibody IHC of human interfollicular zone. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CD135 / FLT3 Antibody (Internal, PE) LS-A106846
Rabbit Polyclonal to Human CD135 / FLT3
Human
ELISA, IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-FLT3 / CD135 antibody IHC of human interfollicular zone. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CD135 / FLT3 Antibody (clone BV10A4H2) LS-B4049
Mouse Monoclonal [clone BV10A4H2] (IgG1) to Human CD135 / FLT3
Human
Flo, IHC, IHC-P
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-FLT3 / CD135 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Anti-FLT3 / CD135 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

IHC-plus™ CD135 / FLT3 Antibody LS-A7147
Rabbit Polyclonal to Human CD135 / FLT3
Rabbit, Dog, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-FLT3 / CD135 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CD135 / FLT3 Antibody (clone A2F10) LS-C106578
Rat Monoclonal [clone A2F10] (IgG2a,k) to Mouse CD135 / FLT3
Mouse
Flo, IP
Unconjugated
50µg 0.5mg/ml  $225.00; 100µg 0.5mg/ml  $245.00; 500µg 0.5mg/ml  $335.00
Two-color surface staining of mouse bone marrow PE anti-mouse CD135 (A2F10) (right) and FITC CD45R/B220 (RA3-6B2). Total viable cells were used for analysis.

CD135 / FLT3 Antibody (clone A2F10, Biotin) LS-C106156
Rat Monoclonal [clone A2F10] (IgG2a,k) to Mouse CD135 / FLT3
Mouse
Flo
Biotin Conjugated
50µg  $215.00; 100µg 0.5mg/ml  $295.00; 500µg  $365.00

CD135 / FLT3 Antibody (clone BV10A4) LS-C112436
Mouse Monoclonal [clone BV10A4] (IgG1) to Human CD135 / FLT3
Human
Flo, IP
Unconjugated
0.1mg 1mg/ml  $255.00

CD135 / FLT3 Antibody (clone BV10A4, FITC) LS-C204850
Mouse Monoclonal [clone BV10A4] (IgG1) to Human CD135 / FLT3
Human
Flo, IP
FITC Conjugated
100tst  $290.00

CD135 / FLT3 Antibody (aa169-444, clone OTI7D6) LS-C340456
Mouse Monoclonal [clone OTI7D6] (IgG1) to Human CD135 / FLT3
Human
WB
Unconjugated
100µl 1mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FLT3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FLT3 (1:500).

CD135 / FLT3 Antibody (phospho-Tyr591) LS-C6859
Rabbit Polyclonal (IgG) to Human CD135 / FLT3
Mouse, Human
WB
Unconjugated
100µl  $575.00

CD135 / FLT3 Antibody (aa33-64) LS-C97535
Rabbit Polyclonal to Human CD135 / FLT3
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of anti-FLT3 antibody in HL-60 cell lysate. FLT3 (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

CD135 / FLT3 Antibody (phospho-Tyr591) LS-C123567
Rabbit Polyclonal (IgG) to Human CD135 / FLT3
Mouse, Human, Monkey
ELISA, IHC, WB
Unconjugated
50µg  $435.00

CD135 / FLT3 Antibody (aa33-64) LS-C327396
Rabbit Polyclonal (IgG) to Human CD135 / FLT3
Human
ELISA, Flo, WB
Unconjugated
200µl  $590.00

IHC-plus™ CD135 / FLT3 Antibody LS-B8864
Rabbit Polyclonal (IgG) to Human CD135 / FLT3
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $545.00
Anti-CD135 / FLT3 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunofluorescence of FLT3 in human kidney tissue with FLT3 antibody at 20 ug/ml.

CD135 / FLT3 Antibody (phospho-Tyr591) LS-C6861
Mouse Monoclonal (IgG2b) to Human CD135 / FLT3
Human
WB
Unconjugated
100µl  $575.00

CD135 / FLT3 Antibody LS-C661936
Rabbit Polyclonal to Mouse CD135 / FLT3
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
100µg  $355.00
Immunohistochemistry - Anti-Flt3 / CD135 Picoband Antibody
Immunohistochemistry - Anti-Flt3 / CD135 Picoband Antibody

CD135 / FLT3 Antibody LS-C809831
Rabbit Polyclonal (IgG) to Human CD135 / FLT3
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

CD135 / FLT3 Antibody LS-C661937
Rabbit Polyclonal to Human CD135 / FLT3
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg  $355.00
Immunohistochemistry - Anti-Flt3 / CD135 Picoband Antibody
Western blot - Anti-Flt3 / CD135 Picoband Antibody

CD135 / FLT3 Antibody (aa930-991, clone 7B7C3) LS-C191859
Mouse Monoclonal [clone 7B7C3] (IgG1) to Human CD135 / FLT3
Human
ELISA, IHC, WB
Unconjugated
100µg 1mg/ml  $365.00
IHC of paraffin-embedded cervical cancer tissues using FLT3 mouse monoclonal antibody with DAB staining.
IHC of paraffin-embedded liver cancer tissues using FLT3 mouse monoclonal antibody with DAB staining.

CD135 / FLT3 Antibody LS-C404568
Rabbit Polyclonal (IgG) to Human CD135 / FLT3
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.4mg/ml  $205.00; 60µl 0.4mg/ml  $235.00; 120µl 0.4mg/ml  $295.00; 200µl 0.4mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human thyroid cancer using FLT3 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of paraffin-embedded Human liver cancer using FLT3 Polyclonal Antibody at dilution of 1:30.

IHC-plus™ CD135 / FLT3 Antibody (N-Terminus) LS-A7142
Rabbit Polyclonal to Human CD135 / FLT3
Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-FLT3 / CD135 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CD135 / FLT3 Antibody (phospho-Tyr969) LS-C198966
Rabbit Polyclonal (IgG) to Human CD135 / FLT3
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain, using FLT3 (Phospho-Tyr969) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HepG2 cells treated with Na3VO4 0.3mM 40', using FLT3 (Phospho-Tyr969) Antibody. The lane on the right is blocked with the phospho peptide.
Showing 1-25 of 126 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).