Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

BBC3 / PUMA

BCL2 binding component 3

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Gene Name: BCL2 binding component 3
Family/Subfamily: Apoptosis , not assigned-Apoptosis
Synonyms: BBC3, Bcl-2-binding component 3, BCL2 binding component 3, JFY-1, JFY1, PUMA, PUMA alpha
Target Sequences: NM_014417 NP_055232.1 Q9BXH1

Publications (2)

1
Aberrant activation of notch signaling in human breast cancer. Stylianou S, Clarke RB, Brennan K. Cancer research. 2006 66:1517-25. [PubMed:16452208]
2
Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Ernesto Diaz-Flores, Evan Q Comeaux, Kailyn L Kim, Ella Melnik, Kyle Beckman, Kara L Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S Braun, Charles G Mullighan, Mignon L Loh. Cancer research. 2019 May;79:2339-2351. [Full Text Article] [PubMed:30862722] [PMC:PMC6497548] Related Antibodies: LS-C98860.

☰ Filters
Products
Antibodies (90)
Primary (90)
BBC3 / PUMA (90)
Human (77)
Mouse (37)
Rat (31)
Gibbon (3)
IHC (29)
IHC-P (6)
WB (86)
Flo (1)
ELISA (22)
ICC (11)
IF (4)
IP (2)
Peptide-ELISA (4)
rabbit (85)
mouse (4)
goat (1)
Product Group
IHCPlus (3)
IgG (40)
IgG1 (4)
monoclonal mc (4)
polyclonal pc (86)
10C5G1 (1)
10D4G7 (1)
2A8F6 (1)
2A9G5 (1)
APC (1)
APC Conjugated (5)
Atto 390 Conjugated (2)
Atto 488 Conjugated (2)
Atto 594 Conjugated (2)
Biotin Conjugated (10)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (9)
HRP Conjugated (6)
PE Conjugated (5)
PerCP Conjugated (1)
RPE Conjugated (1)
Sepharose Conjugated (1)
Unconjugated (41)
C-Terminus (19)
N-Terminus (7)
aa109-137 (7)
aa119-154 (7)
aa21-70 (4)
Arg169 (1)
C-terminal (1)
aa120-169 (1)
aa145-159 (1)
aa150-193 (1)
aa158-192 (1)
aa178-187 (1)
aa2-16 (1)
No (89)
Yes (1)
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
BBC3 / PUMA Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Puma BH3 Domain antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
BBC3 / PUMA Antibody - PUMA expression in human dysplastic nevi (premalignant melanoma).
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$386
BBC3 / PUMA Antibody - Immunohistochemistry of PUMA in human breast carcinoma with PUMA antibody at 10 ug/ml.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa2-16) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.05 mg/$495
BBC3 / PUMA Antibody - Anti-BBC3 / PUMA antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa119-154) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
BBC3 / PUMA Antibody - BBC3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cervix tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (aa109-137) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µg/$583
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
25 µg/$320; 100 µg/$442
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$331
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
25 µg/$320; 100 µg/$442
BBC3 / PUMA Antibody - Immunofluorescence analysis of NIH/3T3 cells using BBC3 Polyclonal Antibody at dilution of 1:100 (40x lens).Blue: DAPI for nuclear staining.
Select
BBC3 / PUMA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
BBC3 / PUMA Antibody - Western blot of PUMA expression in K562 cell lysate with PUMA antibody at (A) 2.5 and (B) 5 ug/ml.
Select
BBC3 / PUMA Mouse anti-Human Monoclonal (2A8F6) Antibody
Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$502
Viewing 1-25 of 90 product results


Filtered By:
Products: Antibodies


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).