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Catalog Number Size Price
LS-B2873-50 50 µl $440 
TH / Tyrosine Hydroxylase Antibody - Anti-TH / Tyrosine Hydroxylase antibody IHC of human heart, nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
TH / Tyrosine Hydroxylase Antibody - Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.
TH / Tyrosine Hydroxylase Antibody - Western blot of rat caudate lysate should specific immunolabeling of the ~60k Tyrosine Hydroxylase protein.
TH / Tyrosine Hydroxylase Antibody - Anti-TH / Tyrosine Hydroxylase antibody IHC of human heart, nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
TH / Tyrosine Hydroxylase Antibody - Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.
TH / Tyrosine Hydroxylase Antibody - Western blot of rat caudate lysate should specific immunolabeling of the ~60k Tyrosine Hydroxylase protein.
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PathPlus™ Polyclonal Rabbit anti‑Rat TH / Tyrosine Hydroxylase Antibody (IHC, IF, WB) LS‑B2873

PathPlus™ Polyclonal Rabbit anti‑Rat TH / Tyrosine Hydroxylase Antibody (IHC, IF, WB) LS‑B2873

Note: This antibody replaces LS-C227
Antibody:
TH / Tyrosine Hydroxylase Rabbit anti-Rat Polyclonal Antibody
Application:
IHC, IHC-P, IHC-Fr, IF, WB
Reactivity:
Rat, Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-B2873-50
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
TH / Tyrosine Hydroxylase Rabbit anti-Rat Polyclonal Antibody
Application:
IHC, IHC-P, IHC-Fr, IF, WB
Reactivity:
Rat, Human
Format:
Unconjugated, Unmodified

Specifications

Description
TH (tyrosine hydroxylase) is an enzyme that converts L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), a dopamine precursor. It is the rate-limiting enzyme in the synthesis of catecholamines and plays a key role in the physiology of adrenergic neurons. TH is encoded by four distinct mRNAs produced by alternative splicing of a single primary transcript, and expression of the mRNAs varies in different parts of the nervous system. Mutations in TH are the cause of autosomal recessive Segawa syndrome and are thought to be involved in Parkinson’s disease and schizophrenia. TH deficiency leads to dopa-nonresponsive dystonia and progressive encephalopathy via an impaired ability to synthesize epinephrine, norepinephrine and dopamine. In immunohistochemistry of normal tissue, TH has cytoplasmic positivity in the adrenal medulla, in peripheral sympathetic nerve fibers, and in the caudate nucleus in the brain. References: Nature Structural Biology. 1997. 4 (7): 578–85, PMID 9228951; CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):395-409, PMID: 22483313; Arch Biochem Biophys. 2011 Apr 1;508(1):1-12, PMID: 21176768; Ann Neurol. 2003;54 Suppl 6:S56-65, PMID: 12891655
Target
Rat TH / Tyrosine Hydroxylase
Synonyms
TH | DYT14 | Dystonia 14 | TYH | Tyrosine 3-hydroxylase | Tyrosine hydroxylase | DYT5b | Tyrosine 3-monooxygenase
Host
Rabbit
Reactivity
Rat, Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
SDS-denatured rat Tyrosine Hydroxylase, purified from pheochromocytoma.
Specificity
Specific for the ~60k tyrosine hydroxylase protein
Applications
  • IHC
  • IHC - Paraffin (1:100)
  • IHC - Frozen
  • Immunofluorescence (1:1000)
  • Western blot (1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistochemistry: LS-B2873 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2873 was determined to be 1:100.
Presentation
10 mM HEPES, pH 7.5, 150 mM NaCl, 0.1 mg/mL BSA, 50% Glycerol
Storage
Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About TH / Tyrosine Hydroxylase
P07101 NM_000360 NP_000351.2

Validation

TH / Tyrosine Hydroxylase Antibody - Anti-TH / Tyrosine Hydroxylase antibody IHC of human heart, nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-TH / Tyrosine Hydroxylase antibody IHC of human heart, nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-TH / Tyrosine Hydroxylase antibody IHC of human heart, nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

LSBio Ratings

PathPlus™ TH / Tyrosine Hydroxylase Antibody for IHC, IF/Immunofluorescence, WB/Western LS-B2873 has an LSBio Rating of
Laboratory Validation Score (5)

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 2/29/2024